STRINGSTRING
BAK1 BAK1 PDGFB PDGFB AKT1 AKT1 BRAF BRAF FGF16 FGF16 E2F3 E2F3 FGF10 FGF10 FGF22 FGF22 BAX BAX FGF4 FGF4 HGF HGF E2F2 E2F2 CDK4 CDK4 CDK6 CDK6 FGF20 FGF20 PIK3CA PIK3CA MITF MITF PIK3CD PIK3CD PTEN PTEN MAP2K2 MAP2K2 PDGFA PDGFA FGF7 FGF7 FGF19 FGF19 GADD45A GADD45A CCND1 CCND1 NRAS NRAS IGF1R IGF1R FGF1 FGF1 BAD BAD FGF9 FGF9 FGF5 FGF5 MAP2K1 MAP2K1 AKT3 AKT3 PIK3R1 PIK3R1 PDGFD PDGFD EGF EGF RB1 RB1 MAPK1 MAPK1 FGFR1 FGFR1 IGF1 IGF1 TP53 TP53 CDKN2A CDKN2A CDKN1A CDKN1A POLK POLK PDGFRA PDGFRA FGF8 FGF8 GADD45G GADD45G FGF21 FGF21 PIK3R3 PIK3R3 FGF23 FGF23 E2F1 E2F1 MAPK3 MAPK3 FGF6 FGF6 KRAS KRAS PDGFC PDGFC HRAS HRAS EGFR EGFR GADD45B GADD45B CDH1 CDH1 RAF1 RAF1 PDGFRB PDGFRB FGF2 FGF2 MET MET ARAF ARAF FGF3 FGF3 AKT2 AKT2 FGF18 FGF18 PIK3CB PIK3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BAK1BCL2 antagonist/killer 1. (211 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (761 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
E2F3E2F transcription factor 3. (465 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
E2F2E2F transcription factor 2. (437 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (169 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (253 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
BADBCL2 associated agonist of cell death. (167 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PDGFDPlatelet derived growth factor D. (364 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1233 aa)
RB1RB transcriptional corepressor 1. (929 aa)
MAPK1Mitogen-activated protein kinase. (330 aa)
FGFR1Fibroblast growth factor receptor. (872 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (208 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
POLKDNA polymerase kappa. (870 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
E2F1E2F transcription factor 1. (485 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
RAF1Uncharacterized protein. (668 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (263 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1405 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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