(61 nodes) Acute myeloid leukemia network (Rhinopithecus roxellana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MPO	Myeloperoxidase. (745 aa)
	STAT5A	Signal transducer and activator of transcription. (905 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
	CSF1R	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (761 aa)
	PML	Promyelocytic leukemia. (882 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	ITGAM	Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1198 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (441 aa)
	TCF7L1	Transcription factor 7 like 1. (562 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	IL3	Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (152 aa)
	PER2	Period circadian regulator 2. (1253 aa)
	STAT5B	Signal transducer and activator of transcription. (787 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	MAP2K2	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (399 aa)
	BCL2A1	BCL2 related protein A1. (175 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
	FLT3	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (995 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (253 aa)
	RARA	Retinoic acid receptor alpha. (478 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	STAT3	Signal transducer and activator of transcription. (802 aa)
	BAD	BCL2 associated agonist of cell death. (167 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	CCNA1	Cyclin A1; Belongs to the cyclin family. (465 aa)
	PIM2	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa)
	JUP	Junction plakoglobin. (760 aa)
	CCNA2	Cyclin A2; Belongs to the cyclin family. (432 aa)
	MAPK1	Mitogen-activated protein kinase. (330 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (673 aa)
	CD14	CD14 molecule. (384 aa)
	PIM1	Protein kinase domain-containing protein. (654 aa)
	PIK3R3	Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
	DUSP6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	CEBPE	CCAAT/enhancer-binding protein. (281 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	LOC104670100	Uncharacterized protein. (351 aa)
	LEF1	Lymphoid enhancer binding factor 1. (399 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	KIT	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1003 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	RAF1	Uncharacterized protein. (668 aa)
	CSF2	Colony stimulating factor 2. (144 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (606 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	RPS6KB2	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (975 aa)
	SPI1	Spi-1 proto-oncogene. (270 aa)
	EIF4EBP1	Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSRROP00000002071	ENSRROP00000040614	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.971
AKT1	AKT3	ENSRROP00000002071	ENSRROP00000021339	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.938
AKT1	ARAF	ENSRROP00000002071	ENSRROP00000039765	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	A-Raf proto-oncogene, serine/threonine kinase.	0.435
AKT1	BAD	ENSRROP00000002071	ENSRROP00000020214	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 associated agonist of cell death.	0.979
AKT1	CCND1	ENSRROP00000002071	ENSRROP00000017233	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin D1; Belongs to the cyclin family.	0.478
AKT1	CHUK	ENSRROP00000002071	ENSRROP00000037992	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.988
AKT1	EIF4EBP1	ENSRROP00000002071	ENSRROP00000045518	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Eukaryotic translation initiation factor 4E binding protein 1.	0.599
AKT1	GRB2	ENSRROP00000002071	ENSRROP00000034137	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Growth factor receptor bound protein 2.	0.646
AKT1	HRAS	ENSRROP00000002071	ENSRROP00000035672	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	HRas proto-oncogene, GTPase.	0.656
AKT1	IKBKB	ENSRROP00000002071	ENSRROP00000025159	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.979
AKT1	IKBKG	ENSRROP00000002071	ENSRROP00000002136	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.942
AKT1	JUP	ENSRROP00000002071	ENSRROP00000023676	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Junction plakoglobin.	0.557
AKT1	KIT	ENSRROP00000002071	ENSRROP00000034352	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.515
AKT1	KRAS	ENSRROP00000002071	ENSRROP00000032888	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	KRAS proto-oncogene, GTPase.	0.526
AKT1	MAP2K2	ENSRROP00000002071	ENSRROP00000014534	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily.	0.419
AKT1	MAPK1	ENSRROP00000002071	ENSRROP00000024767	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.966
AKT1	MAPK3	ENSRROP00000002071	ENSRROP00000032094	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.947
AKT1	MTOR	ENSRROP00000002071	ENSRROP00000025215	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.995
AKT1	MYC	ENSRROP00000002071	ENSRROP00000016322	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.599
AKT1	NFKB1	ENSRROP00000002071	ENSRROP00000044836	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear factor kappa B subunit 1.	0.615