26 items (Rhinopithecus roxellana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	HLA-DOA	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
	CD80	CD80 molecule. (288 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (223 aa)
	CD86	CD86 molecule. (329 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
	LOC104676775	Ig-like domain-containing protein; Belongs to the MHC class I family. (391 aa)
	HLA-DPB1	Major histocompatibility complex, class II, DP beta 1. (258 aa)
	LOC104676771	Major histocompatibility complex, class I, F; Belongs to the MHC class I family. (369 aa)
	FAS	Fas cell surface death receptor. (331 aa)
	HLA-DOB	Major histocompatibility complex, class II, DO beta. (273 aa)
	HLA-DPA1	Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (305 aa)
	TG	Thyroglobulin. (2769 aa)
	PRF1	Perforin 1. (555 aa)
	TSHB	Thyroid stimulating hormone subunit beta. (138 aa)
	LOC104666622	Ig-like domain-containing protein. (276 aa)
	HLA-DRA	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
	LOC104675809	Ig-like domain-containing protein. (192 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (280 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
	HLA-E	Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (364 aa)
	TPO	Thyroid peroxidase. (933 aa)
	IL10	Interleukin 10. (178 aa)
	GZMB	Granzyme B; Belongs to the peptidase S1 family. (281 aa)

Your Current Organism:

Rhinopithecus roxellana

NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD40LG	CD80	ENSRROP00000035971	ENSRROP00000001520	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	CD80 molecule.	0.763
CD40LG	CD86	ENSRROP00000035971	ENSRROP00000008396	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	CD86 molecule.	0.756
CD40LG	CTLA4	ENSRROP00000035971	ENSRROP00000008223	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Cytotoxic T-lymphocyte associated protein 4.	0.535
CD40LG	FAS	ENSRROP00000035971	ENSRROP00000026650	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Fas cell surface death receptor.	0.416
CD40LG	FASLG	ENSRROP00000035971	ENSRROP00000036054	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Fas ligand; Belongs to the tumor necrosis factor family.	0.514
CD40LG	IL10	ENSRROP00000035971	ENSRROP00000042923	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Interleukin 10.	0.574
CD40LG	IL2	ENSRROP00000035971	ENSRROP00000009106	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.627
CD40LG	IL4	ENSRROP00000035971	ENSRROP00000038573	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.578
CD40LG	IL5	ENSRROP00000035971	ENSRROP00000006542	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.	0.400
CD80	CD40LG	ENSRROP00000001520	ENSRROP00000035971	CD80 molecule.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.763
CD80	CD86	ENSRROP00000001520	ENSRROP00000008396	CD80 molecule.	CD86 molecule.	0.992
CD80	CTLA4	ENSRROP00000001520	ENSRROP00000008223	CD80 molecule.	Cytotoxic T-lymphocyte associated protein 4.	0.997
CD80	FASLG	ENSRROP00000001520	ENSRROP00000036054	CD80 molecule.	Fas ligand; Belongs to the tumor necrosis factor family.	0.567
CD80	GZMB	ENSRROP00000001520	ENSRROP00000044852	CD80 molecule.	Granzyme B; Belongs to the peptidase S1 family.	0.462
CD80	IL10	ENSRROP00000001520	ENSRROP00000042923	CD80 molecule.	Interleukin 10.	0.638
CD80	IL2	ENSRROP00000001520	ENSRROP00000009106	CD80 molecule.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.603
CD80	IL4	ENSRROP00000001520	ENSRROP00000038573	CD80 molecule.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.705
CD80	IL5	ENSRROP00000001520	ENSRROP00000006542	CD80 molecule.	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.	0.400
CD86	CD40LG	ENSRROP00000008396	ENSRROP00000035971	CD86 molecule.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.756
CD86	CD80	ENSRROP00000008396	ENSRROP00000001520	CD86 molecule.	CD80 molecule.	0.992