STRINGSTRING
HLA-DOA HLA-DOA IL21 IL21 TGFB3 TGFB3 IL6 IL6 IL4R IL4R IL17F IL17F RELA RELA IL1A IL1A IL18R1 IL18R1 TNF TNF NOD2 NOD2 IL12RB1 IL12RB1 IL5 IL5 TLR2 TLR2 NFATC1 NFATC1 IL2 IL2 IL12B IL12B IL22 IL22 IL21R IL21R TLR4 TLR4 IFNG IFNG STAT6 STAT6 STAT3 STAT3 TBX21 TBX21 IFNGR2 IFNGR2 IFNGR1 IFNGR1 GATA3 GATA3 HLA-DPB1 HLA-DPB1 IL2RG IL2RG HLA-DOB HLA-DOB HLA-DPA1 HLA-DPA1 IL18RAP IL18RAP IL13 IL13 FOXP3 FOXP3 IL12RB2 IL12RB2 LOC104666622 LOC104666622 HLA-DRA HLA-DRA TGFB2 TGFB2 STAT1 STAT1 IL17A IL17A IL1B IL1B IL4 IL4 IL12A IL12A TGFB1 TGFB1 IL23R IL23R IL18 IL18 RORA RORA IL10 IL10 STAT4 STAT4 NFKB1 NFKB1 IL23A IL23A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IL6Interleukin 6. (214 aa)
IL4RInterleukin 4 receptor. (825 aa)
IL17FInterleukin 17F. (163 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
IL18R1Interleukin 18 receptor 1. (540 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (661 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
TLR2Toll-like receptor. (784 aa)
NFATC1Nuclear factor of activated T cells 1. (895 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
IL22Interleukin 22. (179 aa)
IL21RUncharacterized protein. (373 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
TBX21T-box transcription factor 21. (531 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
GATA3GATA binding protein 3. (444 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (305 aa)
IL18RAPInterleukin 18 receptor accessory protein. (599 aa)
IL13Interleukin 13. (146 aa)
FOXP3Forkhead box P3. (454 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (863 aa)
LOC104666622Ig-like domain-containing protein. (276 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
IL17AInterleukin 17A. (155 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
IL23RInterleukin 23 receptor. (629 aa)
IL18Interleukin 18. (211 aa)
RORARAR related orphan receptor A. (555 aa)
IL10Interleukin 10. (178 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
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