STRINGSTRING
GSTM5 GSTM5 TXN2 TXN2 SUMO2-2 SUMO2-2 ITGAV ITGAV PDGFB PDGFB AKT1 AKT1 IKBKG IKBKG MAP2K7 MAP2K7 LOC104667407 LOC104667407 CAV3 CAV3 ACVR2A ACVR2A RELA RELA IL1A IL1A MAPK8 MAPK8 ASS1 ASS1 CALML3 CALML3 TNF TNF IL1R2 IL1R2 PECAM1 PECAM1 ACVR1 ACVR1 GSTP1 GSTP1 MAPK9 MAPK9 DUSP1 DUSP1 EDN1 EDN1 MGST2 MGST2 ACTB ACTB LOC104665044 LOC104665044 VCAM1 VCAM1 TNFRSF1A TNFRSF1A ACTG1 ACTG1 GPC1 GPC1 GSTA4 GSTA4 IL1R1 IL1R1 PIK3CA PIK3CA MAP2K6 MAP2K6 PIK3CD PIK3CD MAP3K5 MAP3K5 MAP3K7 MAP3K7 GSTO1 GSTO1 RHOA RHOA PDGFA PDGFA MAP2K4 MAP2K4 ICAM1 ICAM1 PIAS4 PIAS4 ARHGEF2 ARHGEF2 IFNG IFNG SDC2 SDC2 SDC1 SDC1 CALM3 CALM3 SUMO2 SUMO2 ENSRROP00000019822 ENSRROP00000019822 SRC SRC GSTM3 GSTM3 BMPR1B BMPR1B NOS3 NOS3 AKT3 AKT3 PIK3R1 PIK3R1 CAV2 CAV2 ITGB3 ITGB3 CAV1 CAV1 BMPR1A BMPR1A SQSTM1 SQSTM1 KDR KDR PLAT PLAT IKBKB IKBKB GSTO2 GSTO2 LOC104667408 LOC104667408 NOX1 NOX1 MAPK14 MAPK14 TXN TXN NCF1 NCF1 ACVR2B ACVR2B TP53 TP53 LOC104675852 LOC104675852 KLF2 KLF2 TRPV4 TRPV4 MGST1 MGST1 MAPK10 MAPK10 CTSL CTSL FOS FOS MMP2 MMP2 PRKAA1 PRKAA1 CTNNB1 CTNNB1 PIK3R3 PIK3R3 MGST3 MGST3 SELE SELE LOC104662055 LOC104662055 PTK2 PTK2 PRKAA2 PRKAA2 IL1B IL1B KEAP1 KEAP1 BCL2 BCL2 HSP90B1 HSP90B1 CYBA CYBA ITGA2B ITGA2B BMP4 BMP4 HMOX1 HMOX1 CHUK CHUK PRKCZ PRKCZ ENSRROP00000039233 ENSRROP00000039233 RAC2 RAC2 AKT2 AKT2 ENSRROP00000041057 ENSRROP00000041057 MAPK7 MAPK7 CALML6 CALML6 MAP2K5 MAP2K5 VEGFA VEGFA NCF2 NCF2 NQO1 NQO1 SDC4 SDC4 GSTA1 GSTA1 LOC104672237 LOC104672237 HSP90AB1 HSP90AB1 PIK3CB PIK3CB CDH5 CDH5 NPPC NPPC NFE2L2 NFE2L2 CALML4 CALML4 NFKB1 NFKB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSTM5Uncharacterized protein; Belongs to the GST superfamily. (218 aa)
TXN2Thioredoxin domain-containing protein. (166 aa)
SUMO2-2Small ubiquitin-related modifier. (95 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (403 aa)
LOC104667407Uncharacterized protein; Belongs to the GST superfamily. (240 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ASS1Uncharacterized protein. (412 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IL1R2Interleukin 1 receptor type 2. (397 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (756 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
MAPK9Mitogen-activated protein kinase. (387 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
EDN1Endothelin 1. (211 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
ACTBActin beta. (375 aa)
LOC104665044Uncharacterized protein. (455 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
ACTG1Actin gamma 1. (375 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (486 aa)
GSTA4Glutathione S-transferase alpha 4; Belongs to the GST superfamily. (222 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (616 aa)
GSTO1Uncharacterized protein; Belongs to the GST superfamily. (241 aa)
RHOARas homolog family member A. (193 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (169 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
PIAS4Protein inhibitor of activated STAT 4. (529 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1174 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (325 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
SUMO2Small ubiquitin-related modifier. (94 aa)
ENSRROP00000019822Uncharacterized protein; Belongs to the calmodulin family. (141 aa)
SRCTyrosine-protein kinase. (540 aa)
GSTM3Glutathione S-transferase. (225 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SQSTM1Sequestosome 1. (451 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
LOC104667408Uncharacterized protein; Belongs to the GST superfamily. (244 aa)
NOX1NADPH oxidase 1. (564 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (525 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
LOC104675852Uncharacterized protein; Belongs to the GST superfamily. (241 aa)
KLF2Uncharacterized protein. (115 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (341 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
PRKAA1Non-specific serine/threonine protein kinase. (697 aa)
CTNNB1Catenin beta 1. (781 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MGST3Microsomal glutathione S-transferase 3. (166 aa)
SELESelectin E. (612 aa)
LOC104662055EF-hand domain-containing protein; Belongs to the calmodulin family. (75 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1109 aa)
PRKAA2Non-specific serine/threonine protein kinase. (560 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
HSP90B1Heat shock protein 90 beta family member 1. (804 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
HMOX1Heme oxygenase 1. (303 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
ENSRROP00000039233GST N-terminal domain-containing protein. (67 aa)
RAC2Rac family small GTPase 2. (192 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSRROP00000041057Small ubiquitin-related modifier. (122 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
CALML6Calmodulin like 6. (181 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (274 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
GSTA1Glutathione S-transferase. (222 aa)
LOC104672237Thioredoxin domain-containing protein. (104 aa)
HSP90AB1HATPase_c domain-containing protein. (724 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
NPPCNatriuretic peptide C. (126 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
CALML4Calmodulin like 4. (192 aa)
NFKB1Nuclear factor kappa B subunit 1. (975 aa)
Your Current Organism:
Rhinopithecus roxellana
NCBI taxonomy Id: 61622
Other names: Pygathrix roxellana, R. roxellana, golden snub-nosed monkey
Server load: low (20%) [HD]