STRINGSTRING
nagK nagK nagZ nagZ lpoB lpoB rlpA rlpA dacA dacA AML59862.1 AML59862.1 AML59883.1 AML59883.1 mltD mltD AML59942.1 AML59942.1 ddl_2 ddl_2 murC murC murG murG ftsW_1 ftsW_1 murD murD mraY mraY murF murF murE_2 murE_2 ftsI_1 ftsI_1 slt slt ybiS ybiS yceG_2 yceG_2 AML59155.1 AML59155.1 AML59157.1 AML59157.1 amiD_2 amiD_2 ybjG ybjG dacC dacC ddlA ddlA vatD vatD pbpG_1 pbpG_1 chb_1 chb_1 ftsI_3 ftsI_3 mrdB mrdB AML55853.1 AML55853.1 mpl mpl amiB amiB murB murB AML56217.1 AML56217.1 glmU_2 glmU_2 murI murI mrcA_2 mrcA_2 murA murA pbpD pbpD lpoA lpoA uppP uppP emtA_1 emtA_1 AML56947.1 AML56947.1 emtA_2 emtA_2 mrcB mrcB amiC_2 amiC_2 mltA mltA uppS uppS murQ murQ mltF mltF amiA amiA mepA_1 mepA_1 amiD_1 amiD_1 AML58157.1 AML58157.1 AML58200.1 AML58200.1 murJ murJ mipA mipA ftsI_5 ftsI_5 ftsI_4 ftsI_4 pbpG_2 pbpG_2 AML58703.1 AML58703.1 dacD_1 dacD_1 anmK_1 anmK_1 ycfS_2 ycfS_2 emtA_3 emtA_3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nagKN-acetyl-D-glucosamine kinase; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. (304 aa)
nagZBeta N-acetyl-glucosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (345 aa)
lpoBLipoprotein YcfM, part of a salvage pathway of unknown substrate; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Belongs to the LpoB family. (197 aa)
rlpARare lipoprotein A precursor; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (356 aa)
dacAD-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (403 aa)
AML59862.1ErfK/YbiS/YcfS/YnhG family protein. (186 aa)
AML59883.1Putative exported protein. (265 aa)
mltDMembrane-bound lytic murein transglycosylase D precursor. (431 aa)
AML59942.1Prophage lysozyme. (170 aa)
ddl_2D-alanine--D-alanine ligase B; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (306 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (491 aa)
murGUDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (354 aa)
ftsW_1Cell division protein FtsW; Belongs to the SEDS family. (400 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (439 aa)
mraYPhospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (453 aa)
murE_2UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Belongs to the MurCDEF family. MurE subfamily. (471 aa)
ftsI_1Cell division protein FtsI. (587 aa)
sltSoluble lytic murein transglycosylase precursor. (642 aa)
ybiSL,D-transpeptidase YbiS. (304 aa)
yceG_2Protein YceG like. (339 aa)
AML59155.1Exported protein. (164 aa)
AML59157.1L,D-transpeptidase YcbB. (569 aa)
amiD_2N-acetylmuramoyl-L-alanine amidase. (276 aa)
ybjGPutative permease. (201 aa)
dacCD-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (392 aa)
ddlAD-alanine--D-alanine ligase. (368 aa)
vatDAcetyltransferase. (155 aa)
pbpG_1Murein-DD-endopeptidase; Belongs to the peptidase S11 family. (302 aa)
chb_1Beta-hexosaminidase. (887 aa)
ftsI_3Penicillin-binding protein 2 (PBP-2); Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (631 aa)
mrdBRod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (370 aa)
AML55853.1Beta-hexosaminidase. (796 aa)
mplUDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (454 aa)
amiBN-acetylmuramoyl-L-alanine amidase. (584 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (345 aa)
AML56217.1Hypothetical protein. (130 aa)
glmU_2N-acetylglucosamine-1-phosphate uridyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (439 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (260 aa)
mrcA_2Multimodular transpeptidase-transglycosylase. (806 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (414 aa)
pbpDMonofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (244 aa)
lpoALppC putative lipoprotein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family. (680 aa)
uppPUndecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (274 aa)
emtA_1Membrane-bound lytic murein transglycosylase E. (200 aa)
AML56947.1Soluble lytic murein transglycosylase. (303 aa)
emtA_2Membrane-bound lytic murein transglycosylase C precursor; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (358 aa)
mrcBMultimodular transpeptidase-transglycosylase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (837 aa)
amiC_2N-acetylmuramoyl-L-alanine amidase. (417 aa)
mltAMembrane-bound lytic murein transglycosylase A precursor; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (379 aa)
uppSUndecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (230 aa)
murQN-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. (282 aa)
mltFTransglycosylase, Slt family; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. (487 aa)
amiAN-acetylmuramoyl-L-alanine amidase. (294 aa)
mepA_1Murein endopeptidase; Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus. (288 aa)
amiD_1N-acetylmuramoyl-L-alanine amidase. (254 aa)
AML58157.1Lysozyme. (139 aa)
AML58200.1Phage lysin. (165 aa)
murJPutative peptidoglycan lipid II flippase MurJ; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (511 aa)
mipAMltA-interacting protein MipA. (248 aa)
ftsI_5Cell division protein FtsI; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (572 aa)
ftsI_4Cell division protein FtsI. (641 aa)
pbpG_2Murein-DD-endopeptidase; Belongs to the peptidase S11 family. (274 aa)
AML58703.1Gamma-D-Glutamyl-meso-Diaminopimelate Amidase. (251 aa)
dacD_1D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (378 aa)
anmK_1Anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (376 aa)
ycfS_2L,D-transpeptidase YcfS. (338 aa)
emtA_3Membrane-bound lytic murein transglycosylase E. (222 aa)
Your Current Organism:
Serratia rubidaea
NCBI taxonomy Id: 61652
Other names: ATCC 27593, CCUG 10981, CCUG 9286, CIP 103234, DSM 4480, LMG 5019, LMG:5019, NBRC 103169, NCTC 12971, S. rubidaea, Serratia marinorubra, Serratia sp. V1E5a
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