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| | nagK | N-acetyl-D-glucosamine kinase; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. (304 aa) |
| | nagZ | Beta N-acetyl-glucosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (345 aa) |
| | lpoB | Lipoprotein YcfM, part of a salvage pathway of unknown substrate; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Belongs to the LpoB family. (197 aa) |
| | rlpA | Rare lipoprotein A precursor; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (356 aa) |
| | dacA | D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (403 aa) |
| | AML59862.1 | ErfK/YbiS/YcfS/YnhG family protein. (186 aa) |
| | AML59883.1 | Putative exported protein. (265 aa) |
| | mltD | Membrane-bound lytic murein transglycosylase D precursor. (431 aa) |
| | AML59942.1 | Prophage lysozyme. (170 aa) |
| | ddl_2 | D-alanine--D-alanine ligase B; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (306 aa) |
| | murC | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (491 aa) |
| | murG | UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (354 aa) |
| | ftsW_1 | Cell division protein FtsW; Belongs to the SEDS family. (400 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (439 aa) |
| | mraY | Phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa) |
| | murF | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (453 aa) |
| | murE_2 | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Belongs to the MurCDEF family. MurE subfamily. (471 aa) |
| | ftsI_1 | Cell division protein FtsI. (587 aa) |
| | slt | Soluble lytic murein transglycosylase precursor. (642 aa) |
| | ybiS | L,D-transpeptidase YbiS. (304 aa) |
| | yceG_2 | Protein YceG like. (339 aa) |
| | AML59155.1 | Exported protein. (164 aa) |
| | AML59157.1 | L,D-transpeptidase YcbB. (569 aa) |
| | amiD_2 | N-acetylmuramoyl-L-alanine amidase. (276 aa) |
| | ybjG | Putative permease. (201 aa) |
| | dacC | D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (392 aa) |
| | ddlA | D-alanine--D-alanine ligase. (368 aa) |
| | vatD | Acetyltransferase. (155 aa) |
| | pbpG_1 | Murein-DD-endopeptidase; Belongs to the peptidase S11 family. (302 aa) |
| | chb_1 | Beta-hexosaminidase. (887 aa) |
| | ftsI_3 | Penicillin-binding protein 2 (PBP-2); Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (631 aa) |
| | mrdB | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (370 aa) |
| | AML55853.1 | Beta-hexosaminidase. (796 aa) |
| | mpl | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (454 aa) |
| | amiB | N-acetylmuramoyl-L-alanine amidase. (584 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (345 aa) |
| | AML56217.1 | Hypothetical protein. (130 aa) |
| | glmU_2 | N-acetylglucosamine-1-phosphate uridyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (439 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (260 aa) |
| | mrcA_2 | Multimodular transpeptidase-transglycosylase. (806 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (414 aa) |
| | pbpD | Monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (244 aa) |
| | lpoA | LppC putative lipoprotein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family. (680 aa) |
| | uppP | Undecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (274 aa) |
| | emtA_1 | Membrane-bound lytic murein transglycosylase E. (200 aa) |
| | AML56947.1 | Soluble lytic murein transglycosylase. (303 aa) |
| | emtA_2 | Membrane-bound lytic murein transglycosylase C precursor; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (358 aa) |
| | mrcB | Multimodular transpeptidase-transglycosylase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (837 aa) |
| | amiC_2 | N-acetylmuramoyl-L-alanine amidase. (417 aa) |
| | mltA | Membrane-bound lytic murein transglycosylase A precursor; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (379 aa) |
| | uppS | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (230 aa) |
| | murQ | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. (282 aa) |
| | mltF | Transglycosylase, Slt family; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. (487 aa) |
| | amiA | N-acetylmuramoyl-L-alanine amidase. (294 aa) |
| | mepA_1 | Murein endopeptidase; Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus. (288 aa) |
| | amiD_1 | N-acetylmuramoyl-L-alanine amidase. (254 aa) |
| | AML58157.1 | Lysozyme. (139 aa) |
| | AML58200.1 | Phage lysin. (165 aa) |
| | murJ | Putative peptidoglycan lipid II flippase MurJ; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (511 aa) |
| | mipA | MltA-interacting protein MipA. (248 aa) |
| | ftsI_5 | Cell division protein FtsI; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (572 aa) |
| | ftsI_4 | Cell division protein FtsI. (641 aa) |
| | pbpG_2 | Murein-DD-endopeptidase; Belongs to the peptidase S11 family. (274 aa) |
| | AML58703.1 | Gamma-D-Glutamyl-meso-Diaminopimelate Amidase. (251 aa) |
| | dacD_1 | D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (378 aa) |
| | anmK_1 | Anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (376 aa) |
| | ycfS_2 | L,D-transpeptidase YcfS. (338 aa) |
| | emtA_3 | Membrane-bound lytic murein transglycosylase E. (222 aa) |
