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AML55853.1 AML55853.1 glmM glmM murB murB ywqF_1 ywqF_1 wecB_2 wecB_2 glmS glmS glmU_2 glmU_2 pgi pgi murA murA iolC_1 iolC_1 murQ murQ xynB xynB crr crr glk_2 glk_2 manZ_1 manZ_1 manY manY manX_3 manX_3 galU_4 galU_4 tuaD_2 tuaD_2 rffG_2 rffG_2 ptsG_4 ptsG_4 manA_1 manA_1 arnD arnD arnA arnA arnC arnC arnB_2 arnB_2 nagK nagK nagZ nagZ ptsG_3 ptsG_3 galE galE galF galF galU_2 galU_2 galT galT galK galK pgm_2 pgm_2 chb_1 chb_1 ptsG_2 ptsG_2 nagB nagB nagA nagA chiD chiD ptsG_1 ptsG_1 mak mak
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AML55853.1Beta-hexosaminidase. (796 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. (445 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (345 aa)
ywqF_1UDP-glucose dehydrogenase. (420 aa)
wecB_2UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (342 aa)
glmSGlucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa)
glmU_2N-acetylglucosamine-1-phosphate uridyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (439 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (548 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (414 aa)
iolC_1Fructokinase. (311 aa)
murQN-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. (282 aa)
xynBBeta-xylosidase; Belongs to the glycosyl hydrolase 43 family. (496 aa)
crrPTS system, glucose-specific IIA component. (169 aa)
glk_2Glucokinase; Belongs to the bacterial glucokinase family. (320 aa)
manZ_1PTS system, mannose-specific IID component. (281 aa)
manYPTS system, mannose-specific IIC component. (266 aa)
manX_3PTS system, mannose-specific IIA component. (328 aa)
galU_4UTP--glucose-1-phosphate uridylyltransferase. (284 aa)
tuaD_2UDP-glucose dehydrogenase. (447 aa)
rffG_2dTDP-glucose 4,6-dehydratase. (336 aa)
ptsG_4PTS system, maltose and glucose-specific IIC component. (541 aa)
manA_1Mannose-6-phosphate isomerase; Belongs to the mannose-6-phosphate isomerase type 1 family. (392 aa)
arnDPolymyxin resistance protein PmrJ, predicted deacetylase; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. (301 aa)
arnAUDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating); Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the N-terminal section; belongs to the Fmt family. UDP- L-Ara4N formyltransferase subfamily. (660 aa)
arnCPolymyxin resistance protein ArnC, glycosyl transferase; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (327 aa)
arnB_2UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (384 aa)
nagKN-acetyl-D-glucosamine kinase; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. (304 aa)
nagZBeta N-acetyl-glucosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (345 aa)
ptsG_3PTS system, glucose-specific IIB component / PTS system, glucose-specific IIC component. (477 aa)
galEUDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (338 aa)
galFUTP--glucose-1-phosphate uridylyltransferase. (297 aa)
galU_2UTP--glucose-1-phosphate uridylyltransferase. (299 aa)
galTGalactose-1-phosphate uridylyltransferase. (349 aa)
galKGalactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (383 aa)
pgm_2Phosphoglucomutase. (547 aa)
chb_1Beta-hexosaminidase. (887 aa)
ptsG_2PTS system, N-acetylglucosamine-specific IIA component. (662 aa)
nagBGlucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (266 aa)
nagAN-acetylglucosamine-6-phosphate deacetylase. (379 aa)
chiDChitinase; Belongs to the glycosyl hydrolase 18 family. (330 aa)
ptsG_1PTS system, glucose-specific IIC component. (448 aa)
makGlucokinase, ROK family. (316 aa)
Your Current Organism:
Serratia rubidaea
NCBI taxonomy Id: 61652
Other names: ATCC 27593, CCUG 10981, CCUG 9286, CIP 103234, DSM 4480, LMG 5019, LMG:5019, NBRC 103169, NCTC 12971, S. rubidaea, Serratia marinorubra, Serratia sp. V1E5a
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