22 items (Schistosoma mansoni) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A3Q0KC34	Putative adenosine kinase. (341 aa)
	A0A3Q0KC36	Putative adenosine kinase. (341 aa)
	A0A3Q0KEH2	Putative adenosine deaminase. (348 aa)
	A0A3Q0KGU1	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (189 aa)
	A0A3Q0KNG7	Phosphodiesterase. (1022 aa)
	A0A3Q0KPJ1	Hypoxanthine-guanine phosphoribosyltransferase,putative. (227 aa)
	A0A5K4EJM6	5'-nucleotidase. (332 aa)
	A0A5K4EWZ0	Purine nucleoside phosphorylase. (320 aa)
	A0A5K4F3M5	Uncharacterized protein. (994 aa)
	A0A5K4F407	Purine nucleoside phosphorylase. (287 aa)
	A0A5K4F8A3	Uncharacterized protein. (226 aa)
	A0A5K4FBW1	Uncharacterized protein. (249 aa)
	Smp_055990	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Belongs to the adenylosuccinate synthetase family. (426 aa)
	Smp_168500	Hypoxanthine-guanine phosphoribosyltransferase,putative. (228 aa)
	Smp_153160	Adenylate kinase 3, putative; Belongs to the adenylate kinase family. (230 aa)
	Smp_063830	GMP synthetase (Glutamine-hydrolysing). (739 aa)
	Smp_012930	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (509 aa)
	Smp_151260	Putative adenine phosphoribosyltransferase. (142 aa)
	Smp_054410	Putative adenine phosphoribosyltransferase. (196 aa)
	Smp_054360	Putative adenine phosphoribosyltransferase. (186 aa)
	Smp_038030	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (480 aa)
	HGPRT	Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). (284 aa)

Your Current Organism:

Schistosoma mansoni

NCBI taxonomy Id: 6183
Other names: S. mansoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A3Q0KC34	A0A3Q0KC36	A0A3Q0KC34	A0A3Q0KC36	Putative adenosine kinase.	Putative adenosine kinase.	0.903
A0A3Q0KC34	A0A3Q0KEH2	A0A3Q0KC34	A0A3Q0KEH2	Putative adenosine kinase.	Putative adenosine deaminase.	0.986
A0A3Q0KC34	A0A3Q0KNG7	A0A3Q0KC34	A0A3Q0KNG7	Putative adenosine kinase.	Phosphodiesterase.	0.910
A0A3Q0KC34	A0A5K4EJM6	A0A3Q0KC34	A0A5K4EJM6	Putative adenosine kinase.	5'-nucleotidase.	0.903
A0A3Q0KC34	A0A5K4EWZ0	A0A3Q0KC34	A0A5K4EWZ0	Putative adenosine kinase.	Purine nucleoside phosphorylase.	0.963
A0A3Q0KC34	A0A5K4F3M5	A0A3Q0KC34	A0A5K4F3M5	Putative adenosine kinase.	Uncharacterized protein.	0.976
A0A3Q0KC34	A0A5K4F407	A0A3Q0KC34	A0A5K4F407	Putative adenosine kinase.	Purine nucleoside phosphorylase.	0.963
A0A3Q0KC34	A0A5K4FBW1	A0A3Q0KC34	A0A5K4FBW1	Putative adenosine kinase.	Uncharacterized protein.	0.903
A0A3Q0KC34	Smp_012930	A0A3Q0KC34	G4V9I5	Putative adenosine kinase.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.479
A0A3Q0KC34	Smp_038030	A0A3Q0KC34	G4VQX9	Putative adenosine kinase.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.971
A0A3Q0KC34	Smp_054360	A0A3Q0KC34	G4VQJ4	Putative adenosine kinase.	Putative adenine phosphoribosyltransferase.	0.975
A0A3Q0KC34	Smp_054410	A0A3Q0KC34	G4VQJ3	Putative adenosine kinase.	Putative adenine phosphoribosyltransferase.	0.975
A0A3Q0KC34	Smp_055990	A0A3Q0KC34	C4QCD2	Putative adenosine kinase.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Belongs to the adenylosuccinate synthetase family.	0.636
A0A3Q0KC34	Smp_063830	A0A3Q0KC34	G4M0Y0	Putative adenosine kinase.	GMP synthetase (Glutamine-hydrolysing).	0.496
A0A3Q0KC34	Smp_151260	A0A3Q0KC34	G4VQJ2	Putative adenosine kinase.	Putative adenine phosphoribosyltransferase.	0.975
A0A3Q0KC34	Smp_153160	A0A3Q0KC34	G4M079	Putative adenosine kinase.	Adenylate kinase 3, putative; Belongs to the adenylate kinase family.	0.936
A0A3Q0KC36	A0A3Q0KC34	A0A3Q0KC36	A0A3Q0KC34	Putative adenosine kinase.	Putative adenosine kinase.	0.903
A0A3Q0KC36	A0A3Q0KEH2	A0A3Q0KC36	A0A3Q0KEH2	Putative adenosine kinase.	Putative adenosine deaminase.	0.986
A0A3Q0KC36	A0A3Q0KNG7	A0A3Q0KC36	A0A3Q0KNG7	Putative adenosine kinase.	Phosphodiesterase.	0.910
A0A3Q0KC36	A0A5K4EJM6	A0A3Q0KC36	A0A5K4EJM6	Putative adenosine kinase.	5'-nucleotidase.	0.903