31 items (Schistosoma mansoni) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Smp_128690	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1040 aa)
	Smp_010100	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives; Belongs to the radical SAM superfamily. Lipoyl synthase family. (410 aa)
	A0A5K4FF77	Uncharacterized protein. (175 aa)
	A0A5K4FDE9	Uncharacterized protein. (182 aa)
	A0A5K4FCG5	Uncharacterized protein. (123 aa)
	A0A5K4F4M9	Putative dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase. (424 aa)
	A0A5K4EZ50	Acetyltransferase component of pyruvate dehydrogenase complex. (497 aa)
	A0A5K4EM66	Glycine cleavage system P protein. (314 aa)
	A0A5K4ELI3	Glycine cleavage system P protein. (609 aa)
	A0A5K4EL82	Glycine cleavage system P protein. (435 aa)
	A0A5K4EL53	Glycine cleavage system P protein. (497 aa)
	A0A5K4EI18	Pyruvate dehydrogenase E1 component subunit alpha. (383 aa)
	A0A5K4EG06	Aspartate aminotransferase. (417 aa)
	A0A5K4EFL5	Aspartate aminotransferase. (237 aa)
	A0A5K4EFJ8	Aspartate aminotransferase. (155 aa)
	A0A5K4EFB8	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (308 aa)
	A0A5K4EF84	Putative aldehyde dehydrogenase. (396 aa)
	A0A3Q0KVD6	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (496 aa)
	A0A3Q0KSQ6	Putative d-amino acid oxidase. (345 aa)
	A0A3Q0KRX6	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (153 aa)
	A0A3Q0KJW2	Putative dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase. (424 aa)
	A0A3Q0KIS4	Lipoate-protein ligase, putative. (411 aa)
	A0A3Q0KH03	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (483 aa)
	A0A3Q0KGZ5	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (535 aa)
	A0A3Q0KGY5	Aspartate aminotransferase. (188 aa)
	A0A3Q0KF78	2-oxoglutarate dehydrogenase. (1001 aa)
	A0A3Q0KD13	Uncharacterized protein. (295 aa)
	A0A3Q0KC81	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (410 aa)
	A0A3Q0KBK2	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (361 aa)
	Smp_046740	Dihydrolipoyl dehydrogenase. (497 aa)
	Smp_079920	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (393 aa)

Your Current Organism:

Schistosoma mansoni

NCBI taxonomy Id: 6183
Other names: S. mansoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A3Q0KBK2	A0A3Q0KC81	A0A3Q0KBK2	A0A3Q0KC81	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.452
A0A3Q0KBK2	A0A3Q0KD13	A0A3Q0KBK2	A0A3Q0KD13	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Uncharacterized protein.	0.498
A0A3Q0KBK2	A0A3Q0KF78	A0A3Q0KBK2	A0A3Q0KF78	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	2-oxoglutarate dehydrogenase.	0.977
A0A3Q0KBK2	A0A3Q0KH03	A0A3Q0KBK2	A0A3Q0KH03	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.999
A0A3Q0KBK2	A0A3Q0KIS4	A0A3Q0KBK2	A0A3Q0KIS4	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Lipoate-protein ligase, putative.	0.944
A0A3Q0KBK2	A0A3Q0KJW2	A0A3Q0KBK2	A0A3Q0KJW2	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Putative dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase.	0.989
A0A3Q0KBK2	A0A3Q0KRX6	A0A3Q0KBK2	A0A3Q0KRX6	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.946
A0A3Q0KBK2	A0A3Q0KVD6	A0A3Q0KBK2	A0A3Q0KVD6	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.995
A0A3Q0KBK2	A0A5K4EFB8	A0A3Q0KBK2	A0A5K4EFB8	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.993
A0A3Q0KBK2	A0A5K4EI18	A0A3Q0KBK2	A0A5K4EI18	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Pyruvate dehydrogenase E1 component subunit alpha.	0.999
A0A3Q0KBK2	A0A5K4EZ50	A0A3Q0KBK2	A0A5K4EZ50	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Acetyltransferase component of pyruvate dehydrogenase complex.	0.999
A0A3Q0KBK2	A0A5K4F4M9	A0A3Q0KBK2	A0A5K4F4M9	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Putative dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase.	0.989
A0A3Q0KBK2	A0A5K4FCG5	A0A3Q0KBK2	A0A5K4FCG5	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Uncharacterized protein.	0.718
A0A3Q0KBK2	A0A5K4FDE9	A0A3Q0KBK2	A0A5K4FDE9	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Uncharacterized protein.	0.718
A0A3Q0KBK2	A0A5K4FF77	A0A3Q0KBK2	A0A5K4FF77	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Uncharacterized protein.	0.509
A0A3Q0KBK2	Smp_010100	A0A3Q0KBK2	C4PZQ3	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives; Belongs to the radical SAM superfamily. Lipoyl synthase family.	0.452
A0A3Q0KBK2	Smp_046740	A0A3Q0KBK2	G4VCN8	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Dihydrolipoyl dehydrogenase.	0.999
A0A3Q0KBK2	Smp_079920	A0A3Q0KBK2	G4VT40	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.999
A0A3Q0KC81	A0A3Q0KBK2	A0A3Q0KC81	A0A3Q0KBK2	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.452
A0A3Q0KC81	A0A3Q0KF78	A0A3Q0KC81	A0A3Q0KF78	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	2-oxoglutarate dehydrogenase.	0.625