STRINGSTRING
PKM PKM CYBC1 CYBC1 CD8A CD8A LGALS8 LGALS8 SLC35B2 SLC35B2 PSMC5 PSMC5 ZNF695 ZNF695 TNFRSF11B TNFRSF11B RTCB RTCB KRAS KRAS IL15 IL15 MYD88 MYD88 CDH1 CDH1 BORCS8 BORCS8 C12orf73 C12orf73 HYAL1 HYAL1 NAALAD2 NAALAD2 TWF2 TWF2 PCSK7 PCSK7 LOC100607462 LOC100607462 AVP AVP ITPA ITPA G3BP2 G3BP2 SYP SYP XPA XPA RCN2 RCN2 HRAS HRAS GRP GRP GET4 GET4 KLHL21 KLHL21 LRP1B LRP1B ZG16B ZG16B TMEM222 TMEM222 SAT2 SAT2 CTC1 CTC1 ZNF671 ZNF671 JUP JUP CCDC167 CCDC167 EMC8 EMC8 RIOK1 RIOK1 RBBP6 RBBP6 MYCL MYCL FUBP3 FUBP3 EXOSC2 EXOSC2 SSRP1 SSRP1 AKIRIN2 AKIRIN2 MS4A3 MS4A3 RTN1 RTN1 AVPR2 AVPR2 RPL36 RPL36 TTC37 TTC37 PGBD5 PGBD5 MPP1 MPP1 RBBP5 RBBP5 SUPT16H SUPT16H C14orf93 C14orf93 FBXL15 FBXL15 SLK SLK STC1 STC1 CRMP1 CRMP1 RPA1 RPA1 CHGA CHGA LOC100593588 LOC100593588 NMNAT2 NMNAT2 GCNT4 GCNT4 EIF2S3B EIF2S3B ERAS ERAS WDR89 WDR89 STK38L STK38L ENSNLEP00000024971 ENSNLEP00000024971 HILPDA HILPDA TMPO TMPO C2CD5 C2CD5 LOC100580287 LOC100580287 RPL32 RPL32 SNAPIN SNAPIN UBE2C UBE2C CRELD2 CRELD2 ASCL1 ASCL1 ENSNLEP00000027860 ENSNLEP00000027860 EIF3M EIF3M AKT1 AKT1 DCLRE1C DCLRE1C CEACAM6 CEACAM6 ENSNLEP00000029112 ENSNLEP00000029112 KRT6A KRT6A CACNA1A CACNA1A ENSNLEP00000029621 ENSNLEP00000029621 HNRNPK HNRNPK ENSNLEP00000030250 ENSNLEP00000030250 ENSNLEP00000030341 ENSNLEP00000030341 APEX2 APEX2 ENSNLEP00000033205 ENSNLEP00000033205 ENSNLEP00000033454 ENSNLEP00000033454 CCT5 CCT5 ENSNLEP00000034618 ENSNLEP00000034618 TRPM6 TRPM6 ENSNLEP00000034742 ENSNLEP00000034742 NUP98 NUP98 EIF2S3 EIF2S3 ENSNLEP00000035499 ENSNLEP00000035499 YTHDF3 YTHDF3 FERMT2 FERMT2 EGFR EGFR LIMK1 LIMK1 RBX1 RBX1 LOC100599867 LOC100599867 ENSNLEP00000036471 ENSNLEP00000036471 KRT6C KRT6C CCT6A CCT6A HAUS3 HAUS3 AVPR1B AVPR1B RPL19 RPL19 TP53I3 TP53I3 PLAUR PLAUR SCRIB SCRIB RTN2 RTN2 ENSNLEP00000037524 ENSNLEP00000037524 ENSNLEP00000037705 ENSNLEP00000037705 DCUN1D1 DCUN1D1 TRPT1 TRPT1 NRAS NRAS LOC100588959 LOC100588959 ANKFY1 ANKFY1 DLL3 DLL3 TPD52 TPD52 GRSF1 GRSF1 ENSNLEP00000042428 ENSNLEP00000042428 ATP5F1A ATP5F1A ENSNLEP00000044387 ENSNLEP00000044387 CACNA1D CACNA1D RPL32-2 RPL32-2 SMOX SMOX ENSNLEP00000045606 ENSNLEP00000045606 ENSNLEP00000046239 ENSNLEP00000046239 SLC3A2 SLC3A2 EIF3J EIF3J YTHDF2 YTHDF2 RARG RARG ATP6V1F ATP6V1F HDHD2 HDHD2 NCAM1 NCAM1 ENSNLEP00000048918 ENSNLEP00000048918 ENSNLEP00000048995 ENSNLEP00000048995
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (530 aa)
CYBC1Cytochrome b-245 chaperone 1. (189 aa)
CD8ACD8a molecule. (235 aa)
LGALS8Galectin. (359 aa)
SLC35B2Solute carrier family 35 member B2. (432 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
ZNF695Zinc finger protein 695. (514 aa)
TNFRSF11BTNF receptor superfamily member 11b. (428 aa)
RTCBRNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. (505 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
BORCS8Uncharacterized protein. (104 aa)
C12orf73Chromosome 12 open reading frame 73. (71 aa)
HYAL1Hyaluronidase. (435 aa)
NAALAD2N-acetylated alpha-linked acidic dipeptidase 2. (718 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
PCSK7Proprotein convertase subtilisin/kexin type 7. (707 aa)
LOC100607462Uncharacterized protein. (741 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
ITPAInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (188 aa)
G3BP2G3BP stress granule assembly factor 2. (482 aa)
SYPSynaptophysin. (313 aa)
XPAXPA, DNA damage recognition and repair factor. (264 aa)
RCN2Reticulocalbin 2. (371 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GRPGastrin releasing peptide. (148 aa)
GET4Uncharacterized protein. (227 aa)
KLHL21Kelch like family member 21. (587 aa)
LRP1BLDL receptor related protein 1B. (4598 aa)
ZG16BZymogen granule protein 16B. (211 aa)
TMEM222Transmembrane protein 222. (208 aa)
SAT2Spermidine/spermine N1-acetyltransferase family member 2. (170 aa)
CTC1CST telomere replication complex component 1. (1159 aa)
ZNF671Zinc finger protein 671. (533 aa)
JUPJunction plakoglobin. (730 aa)
CCDC167Coiled-coil domain containing 167. (97 aa)
EMC8ER membrane protein complex subunit 8. (210 aa)
RIOK1Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (535 aa)
RBBP6RB binding protein 6, ubiquitin ligase. (1680 aa)
MYCLMYCL proto-oncogene, bHLH transcription factor. (364 aa)
FUBP3Far upstream element binding protein 3. (529 aa)
EXOSC2Exosome component 2. (293 aa)
SSRP1FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa)
AKIRIN2Akirin 2. (203 aa)
MS4A3Membrane spanning 4-domains A3. (229 aa)
RTN1Reticulon. (724 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (371 aa)
RPL3660S ribosomal protein L36; Belongs to the eukaryotic ribosomal protein eL36 family. (105 aa)
TTC37Tetratricopeptide repeat domain 37. (1486 aa)
PGBD5Uncharacterized protein. (432 aa)
MPP1Membrane palmitoylated protein 1; Belongs to the MAGUK family. (466 aa)
RBBP5RB binding protein 5, histone lysine methyltransferase complex subunit. (548 aa)
SUPT16HSPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa)
C14orf93Chromosome 14 open reading frame 93. (537 aa)
FBXL15F-box and leucine rich repeat protein 15. (300 aa)
SLKSTE20 like kinase. (1223 aa)
STC1Stanniocalcin 1. (247 aa)
CRMP1Collapsin response mediator protein 1. (682 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
CHGAChromogranin A. (460 aa)
LOC100593588IF rod domain-containing protein; Belongs to the intermediate filament family. (564 aa)
NMNAT2Nicotinamide nucleotide adenylyltransferase 2. (307 aa)
GCNT4Glucosaminyl (N-acetyl) transferase 4. (453 aa)
EIF2S3BTr-type G domain-containing protein. (339 aa)
ERASES cell expressed Ras. (233 aa)
WDR89WD repeat domain 89. (389 aa)
STK38LNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (464 aa)
ENSNLEP00000024971UBIQUITIN_CONJUGAT_2 domain-containing protein. (192 aa)
HILPDAHypoxia inducible lipid droplet associated. (63 aa)
TMPOThymopoietin. (694 aa)
C2CD5C2 calcium dependent domain containing 5. (1042 aa)
LOC100580287RRM domain-containing protein. (430 aa)
RPL32Ribosomal protein L32. (152 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
UBE2CUbiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
CRELD2Cysteine rich with EGF like domains 2. (353 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (235 aa)
ENSNLEP00000027860Uncharacterized protein. (115 aa)
EIF3MEukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (374 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
DCLRE1CUncharacterized protein. (685 aa)
CEACAM6Carcinoembryonic antigen related cell adhesion molecule 6. (310 aa)
ENSNLEP00000029112Uncharacterized protein. (464 aa)
KRT6AKeratin 6A; Belongs to the intermediate filament family. (564 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2399 aa)
ENSNLEP00000029621Uncharacterized protein. (426 aa)
HNRNPKUncharacterized protein. (475 aa)
ENSNLEP00000030250Uncharacterized protein. (123 aa)
ENSNLEP00000030341WD_REPEATS_REGION domain-containing protein. (324 aa)
APEX2Uncharacterized protein. (416 aa)
ENSNLEP00000033205Pyruvate kinase; Belongs to the pyruvate kinase family. (612 aa)
ENSNLEP00000033454Uncharacterized protein. (120 aa)
CCT5Chaperonin containing TCP1 subunit 5. (486 aa)
ENSNLEP00000034618ROKNT domain-containing protein. (87 aa)
TRPM6Transient receptor potential cation channel subfamily M member 6. (2022 aa)
ENSNLEP00000034742Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. (185 aa)
NUP98Nucleoporin 98. (1503 aa)
EIF2S3Eukaryotic translation initiation factor 2 subunit gamma. (415 aa)
ENSNLEP00000035499Uncharacterized protein. (97 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (587 aa)
FERMT2Fermitin family member 2. (693 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
LIMK1Uncharacterized protein. (614 aa)
RBX1Ring-box 1. (108 aa)
LOC100599867Uncharacterized protein. (250 aa)
ENSNLEP00000036471Uncharacterized protein. (135 aa)
KRT6CIF rod domain-containing protein; Belongs to the intermediate filament family. (564 aa)
CCT6AChaperonin containing TCP1 subunit 6A. (531 aa)
HAUS3HAUS-augmin3 domain-containing protein. (489 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (426 aa)
RPL19Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. (195 aa)
TP53I3Tumor protein p53 inducible protein 3. (346 aa)
PLAURPlasminogen activator, urokinase receptor. (335 aa)
SCRIBScribble planar cell polarity protein. (1449 aa)
RTN2Reticulon. (546 aa)
ENSNLEP00000037524Uncharacterized protein. (248 aa)
ENSNLEP00000037705Uncharacterized protein. (443 aa)
DCUN1D1DCN1-like protein. (271 aa)
TRPT1tRNA phosphotransferase 1. (253 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LOC100588959Pyruvate kinase; Belongs to the pyruvate kinase family. (512 aa)
ANKFY1Ankyrin repeat and FYVE domain containing 1. (1211 aa)
DLL3Delta like canonical Notch ligand 3. (619 aa)
TPD52Uncharacterized protein. (268 aa)
GRSF1Uncharacterized protein. (550 aa)
ENSNLEP00000042428Uncharacterized protein. (392 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (545 aa)
ENSNLEP0000004438760S ribosomal protein L36; Belongs to the eukaryotic ribosomal protein eL36 family. (103 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2116 aa)
RPL32-2Uncharacterized protein. (135 aa)
SMOXSpermine oxidase. (585 aa)
ENSNLEP00000045606UBIQUITIN_CONJUGAT_2 domain-containing protein. (197 aa)
ENSNLEP00000046239Prot_ATP_ID_OB domain-containing protein. (183 aa)
SLC3A2Solute carrier family 3 member 2. (624 aa)
EIF3JEukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (259 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (595 aa)
RARGRetinoic acid receptor gamma. (441 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (147 aa)
HDHD2Haloacid dehalogenase like hydrolase domain containing 2. (259 aa)
NCAM1Neural cell adhesion molecule 1. (884 aa)
ENSNLEP00000048918UBIQUITIN_CONJUGAT_2 domain-containing protein. (165 aa)
ENSNLEP00000048995Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. (182 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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