STRINGSTRING
NT5C NT5C AK7 AK7 UPP2 UPP2 GMPR GMPR NT5C1B NT5C1B HPRT1 HPRT1 AMPD2 AMPD2 GMPS GMPS UPP1 UPP1 ENTPD3 ENTPD3 IMPDH2 IMPDH2 ATIC ATIC CDA CDA NME4 NME4 NME3 NME3 AK3 AK3 ENTPD8 ENTPD8 CTPS2 CTPS2 AK5 AK5 PNP PNP NT5C3B NT5C3B PDE8A PDE8A CTPS1 CTPS1 AK9 AK9 NT5E NT5E ENTPD1 ENTPD1 ENPP3 ENPP3 ENPP1 ENPP1 UCK2 UCK2 NME7 NME7 THTPA THTPA NT5C3A NT5C3A APRT APRT DCTPP1 DCTPP1 ENTPD5 ENTPD5 ADSS1 ADSS1 CMPK1 CMPK1 RRM1 RRM1 AK1 AK1 PDE1B PDE1B HDDC3 HDDC3 NT5C2 NT5C2 ADK ADK NUDT16 NUDT16 AK2 AK2 DCTD DCTD AK4-2 AK4-2 NME1-NME2 NME1-NME2 AMPD1 AMPD1 TPK1 TPK1 NUDT2 NUDT2 ENTPD6 ENTPD6 DCK DCK NME6 NME6 PDE1A PDE1A ENSNLEP00000036501 ENSNLEP00000036501 ADSS2 ADSS2 RRM2B RRM2B RRM2 RRM2 LOC100581732 LOC100581732 PDE8B PDE8B ADSL ADSL UPRT UPRT AK6 AK6 ENTPD4 ENTPD4 PDE1C PDE1C LOC100582337 LOC100582337 ADA2 ADA2 GUK1 GUK1 TK2 TK2 AMPD3 AMPD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NT5C5', 3'-nucleotidase, cytosolic. (201 aa)
AK7Adenylate kinase 7. (689 aa)
UPP2Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (363 aa)
GMPRGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa)
NT5C1BUncharacterized protein. (609 aa)
HPRT1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
AMPD2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (879 aa)
GMPSGuanine monophosphate synthase. (693 aa)
UPP1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (310 aa)
ENTPD3Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (529 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (592 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
NME4Nucleoside diphosphate kinase. (187 aa)
NME3Nucleoside diphosphate kinase. (169 aa)
AK3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (223 aa)
ENTPD8Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (495 aa)
CTPS2CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (586 aa)
AK5Adenylate kinase 5; Belongs to the adenylate kinase family. (562 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
NT5C3B5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa)
PDE8APhosphodiesterase. (829 aa)
CTPS1CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (591 aa)
AK9Adenylate kinase 9. (1911 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa)
ENTPD1Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (502 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase 3. (874 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (827 aa)
UCK2Uridine-cytidine kinase 2. (228 aa)
NME7Nucleoside diphosphate kinase 7; Belongs to the NDK family. (376 aa)
THTPAThiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP). (230 aa)
NT5C3A5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (336 aa)
APRTAdenine phosphoribosyltransferase. (180 aa)
DCTPP1dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (170 aa)
ENTPD5Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family. (428 aa)
ADSS1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (457 aa)
CMPK1UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa)
AK1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (210 aa)
PDE1BPhosphodiesterase. (536 aa)
HDDC3HD domain-containing protein. (140 aa)
NT5C25'-nucleotidase, cytosolic II. (584 aa)
ADKAdenosine kinase. (362 aa)
NUDT16Nudix hydrolase 16. (227 aa)
AK2Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (239 aa)
DCTDdCMP deaminase. (178 aa)
AK4-2ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (209 aa)
NME1-NME2Nucleoside diphosphate kinase. (292 aa)
AMPD1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (780 aa)
TPK1Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (233 aa)
NUDT2Nudix hydrolase 2. (147 aa)
ENTPD6Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (484 aa)
DCKdNK domain-containing protein. (317 aa)
NME6Nucleoside diphosphate kinase. (194 aa)
PDE1APhosphodiesterase. (544 aa)
ENSNLEP00000036501Uncharacterized protein. (326 aa)
ADSS2Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (458 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (355 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (448 aa)
LOC100581732Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (581 aa)
PDE8BPhosphodiesterase. (781 aa)
ADSLAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (498 aa)
UPRTUncharacterized protein. (173 aa)
AK6Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (172 aa)
ENTPD4Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (617 aa)
PDE1CPhosphodiesterase. (766 aa)
LOC100582337Nucleoside diphosphate kinase. (147 aa)
ADA2Adenosine deaminase 2. (503 aa)
GUK1Guanylate kinase-like domain-containing protein. (272 aa)
TK2Thymidine kinase 2. (296 aa)
AMPD3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (776 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.