STRINGSTRING
CIAO1 CIAO1 GLRX5 GLRX5 NARF NARF CIAPIN1 CIAPIN1 CIAO2B CIAO2B MOCOS MOCOS ISCU ISCU CIAO3 CIAO3 NUBP2 NUBP2 NDOR1 NDOR1 NFU1 NFU1 NUBP1 NUBP1 NFS1 NFS1 SCLY SCLY FDX2 FDX2 MMS19 MMS19 IBA57 IBA57 ISCA2 ISCA2 GLRX3 GLRX3 BOLA3 BOLA3 ENSNLEP00000027644 ENSNLEP00000027644 ENSNLEP00000027909 ENSNLEP00000027909 BOLA2B BOLA2B ENSNLEP00000032560 ENSNLEP00000032560 ISCA1 ISCA1 LYRM4 LYRM4 CIAO2A CIAO2A ENSNLEP00000035899 ENSNLEP00000035899 CIAPIN1-2 CIAPIN1-2 ENSNLEP00000037793 ENSNLEP00000037793 ENSNLEP00000040645 ENSNLEP00000040645 ENSNLEP00000045065 ENSNLEP00000045065 ENSNLEP00000048874 ENSNLEP00000048874
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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CIAO1Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation; Belongs to the WD repeat CIA1 family. (326 aa)
GLRX5Glutaredoxin 5. (157 aa)
NARFNuclear prelamin A recognition factor; Belongs to the NARF family. (478 aa)
CIAPIN1Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] (312 aa)
CIAO2BCytosolic iron-sulfur assembly component 2B. (163 aa)
MOCOSMolybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (889 aa)
ISCUIron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (167 aa)
CIAO3Cytosolic iron-sulfur assembly component 3; Belongs to the NARF family. (475 aa)
NUBP2Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (271 aa)
NDOR1NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (595 aa)
NFU1NFU1 iron-sulfur cluster scaffold. (230 aa)
NUBP1Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (320 aa)
NFS1Aminotran_5 domain-containing protein. (612 aa)
SCLYSelenocysteine lyase. (418 aa)
FDX22Fe-2S ferredoxin-type domain-containing protein. (186 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (1030 aa)
IBA57Iron-sulfur cluster assembly factor IBA57. (357 aa)
ISCA2Iron-sulfur cluster assembly 2. (154 aa)
GLRX3Uncharacterized protein. (335 aa)
BOLA3BolA family member 3; Belongs to the BolA/IbaG family. (107 aa)
ENSNLEP00000027644Uncharacterized protein. (134 aa)
ENSNLEP00000027909Fe-S_biosyn domain-containing protein. (117 aa)
BOLA2BUncharacterized protein; Belongs to the BolA/IbaG family. (152 aa)
ENSNLEP00000032560Nfu_N domain-containing protein. (232 aa)
ISCA1Iron-sulfur cluster assembly 1. (129 aa)
LYRM4LYR motif containing 4; Belongs to the complex I LYR family. (130 aa)
CIAO2ACytosolic iron-sulfur assembly component 2A. (160 aa)
ENSNLEP00000035899Uncharacterized protein. (321 aa)
CIAPIN1-2Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] (297 aa)
ENSNLEP00000037793Uncharacterized protein. (122 aa)
ENSNLEP00000040645Fe-S_biosyn domain-containing protein. (114 aa)
ENSNLEP00000045065Fe-S_biosyn domain-containing protein. (155 aa)
ENSNLEP00000048874Uncharacterized protein. (178 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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