70 items (Nomascus leucogenys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
	TBC1D7	TBC1 domain family member 7. (293 aa)
	SLC38A9	Solute carrier family 38 member 9. (561 aa)
	RPS6KA6	Ribosomal protein S6 kinase. (738 aa)
	KPTN	Kaptin, actin binding protein. (429 aa)
	CASTOR1	Cytosolic arginine sensor for mTORC1 subunit 1. (346 aa)
	LAMTOR5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (173 aa)
	RHEB	Ras homolog, mTORC1 binding. (184 aa)
	DEPDC5	DEP domain-containing protein. (1602 aa)
	DEPTOR	DEP domain containing MTOR interacting protein. (392 aa)
	AKT1S1	AKT1 substrate 1. (276 aa)
	RPS6KB2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (447 aa)
	FNIP2	Folliculin interacting protein 2. (1113 aa)
	NPRL2	NPR2 like, GATOR1 complex subunit. (380 aa)
	G1R844_NOMLE	Uncharacterized protein. (1610 aa)
	NPRL3	NPR3 like, GATOR1 complex subunit. (505 aa)
	PHLPP1	Uncharacterized protein. (1264 aa)
	CASTOR2	ACT_7 domain-containing protein. (169 aa)
	SEH1L	SEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (360 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (744 aa)
	LOC100592336	PH_3 domain-containing protein. (247 aa)
	TRIB3	Tribbles pseudokinase 3. (385 aa)
	RPS6KA3	Ribosomal protein S6 kinase. (732 aa)
	PKN2	Uncharacterized protein. (984 aa)
	BMT2	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
	RPS6KA2	Non-specific serine/threonine protein kinase. (692 aa)
	RRAGC	Ras related GTP binding C. (376 aa)
	TSC1	TSC complex subunit 1. (1164 aa)
	WDR59	WD repeat domain 59. (1027 aa)
	RRAGD	Ras related GTP binding D. (400 aa)
	FLCN	Folliculin. (542 aa)
	DMRTC2	DMRT like family C2. (367 aa)
	LAMTOR3	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
	SGK1	Non-specific serine/threonine protein kinase. (526 aa)
	MIOS	Meiosis regulator for oocyte development. (875 aa)
	RICTOR	RPTOR independent companion of MTOR complex 2. (1709 aa)
	DDIT4	DNA damage inducible transcript 4. (232 aa)
	C12orf66	Chromosome 12 open reading frame 66. (468 aa)
	LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (149 aa)
	PKN3	Protein kinase N3. (895 aa)
	RHEBL1	RHEB like 1. (183 aa)
	RRAGA	Ras related GTP binding A. (313 aa)
	SGK3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	ENSNLEP00000024738	DMA domain-containing protein. (449 aa)
	WDR24	WD repeat domain 24. (903 aa)
	SGK2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa)
	ENSNLEP00000026906	Hr1 domain-containing protein. (311 aa)
	ENSNLEP00000027037	Mitochondrial inner membrane protease subunit. (144 aa)
	ENSNLEP00000029688	Tankyrase_bdg_C domain-containing protein. (391 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1318 aa)
	CRYGN	Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (124 aa)
	LAMTOR2	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
	RRAGB	Ras related GTP binding B. (374 aa)
	ENSNLEP00000033843	Uncharacterized protein. (63 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
	ARHGAP8	Uncharacterized protein. (470 aa)
	FNIP1	Folliculin interacting protein 1. (1165 aa)
	MLST8	MTOR associated protein, LST8 homolog. (326 aa)
	ENSNLEP00000037075	Uncharacterized protein. (572 aa)
	EEF2K	Eukaryotic elongation factor 2 kinase. (725 aa)
	FKBP8	FKBP prolyl isomerase 8. (397 aa)
	TSC2	TSC complex subunit 2. (1777 aa)
	PHLPP2	PH domain and leucine rich repeat protein phosphatase 2. (1317 aa)
	LOC100593010	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (398 aa)
	ENSNLEP00000042279	Uncharacterized protein. (587 aa)
	ENSNLEP00000044560	Uncharacterized protein. (109 aa)
	MAPKAP1	MAPK associated protein 1. (523 aa)
	SESN3	Sestrin 3. (520 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1S1	AKT2	ENSNLEP00000006561	ENSNLEP00000042041	AKT1 substrate 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.751
AKT1S1	AKT3	ENSNLEP00000006561	ENSNLEP00000023896	AKT1 substrate 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.971
AKT1S1	CRYGN	ENSNLEP00000006561	ENSNLEP00000031358	AKT1 substrate 1.	Uncharacterized protein; Belongs to the beta/gamma-crystallin family.	0.526
AKT1S1	DEPTOR	ENSNLEP00000006561	ENSNLEP00000006084	AKT1 substrate 1.	DEP domain containing MTOR interacting protein.	0.983
AKT1S1	ENSNLEP00000029688	ENSNLEP00000006561	ENSNLEP00000029688	AKT1 substrate 1.	Tankyrase_bdg_C domain-containing protein.	0.526
AKT1S1	ENSNLEP00000044560	ENSNLEP00000006561	ENSNLEP00000044560	AKT1 substrate 1.	Uncharacterized protein.	0.538
AKT1S1	FKBP8	ENSNLEP00000006561	ENSNLEP00000038356	AKT1 substrate 1.	FKBP prolyl isomerase 8.	0.832
AKT1S1	G1R844_NOMLE	ENSNLEP00000006561	ENSNLEP00000009378	AKT1 substrate 1.	Uncharacterized protein.	0.526
AKT1S1	LAMTOR1	ENSNLEP00000006561	ENSNLEP00000020929	AKT1 substrate 1.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.667
AKT1S1	LAMTOR2	ENSNLEP00000006561	ENSNLEP00000031658	AKT1 substrate 1.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2.	0.643
AKT1S1	LAMTOR3	ENSNLEP00000006561	ENSNLEP00000016595	AKT1 substrate 1.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3.	0.538
AKT1S1	LAMTOR5	ENSNLEP00000006561	ENSNLEP00000004377	AKT1 substrate 1.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5.	0.625
AKT1S1	LOC100593010	ENSNLEP00000006561	ENSNLEP00000040615	AKT1 substrate 1.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.502
AKT1S1	MAPKAP1	ENSNLEP00000006561	ENSNLEP00000047528	AKT1 substrate 1.	MAPK associated protein 1.	0.975
AKT1S1	MLST8	ENSNLEP00000006561	ENSNLEP00000036779	AKT1 substrate 1.	MTOR associated protein, LST8 homolog.	0.999
AKT1S1	MTOR	ENSNLEP00000006561	ENSNLEP00000033904	AKT1 substrate 1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.996
AKT1S1	RHEB	ENSNLEP00000006561	ENSNLEP00000005480	AKT1 substrate 1.	Ras homolog, mTORC1 binding.	0.985
AKT1S1	RHEBL1	ENSNLEP00000006561	ENSNLEP00000021681	AKT1 substrate 1.	RHEB like 1.	0.553
AKT1S1	RICTOR	ENSNLEP00000006561	ENSNLEP00000019922	AKT1 substrate 1.	RPTOR independent companion of MTOR complex 2.	0.890
AKT1S1	RPS6KA1	ENSNLEP00000006561	ENSNLEP00000011368	AKT1 substrate 1.	Ribosomal protein S6 kinase.	0.456

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