(24 nodes) Mixed, incl. Ribosomal protein S6 kinase activity, and TOR complex network (Nomascus leucogenys)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Others

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Your Input:
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
	TBC1D7	TBC1 domain family member 7. (293 aa)
	RPS6KA6	Ribosomal protein S6 kinase. (738 aa)
	RHEB	Ras homolog, mTORC1 binding. (184 aa)
	DEPTOR	DEP domain containing MTOR interacting protein. (392 aa)
	AKT1S1	AKT1 substrate 1. (276 aa)
	RPS6KB2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (447 aa)
	G1R844_NOMLE	Uncharacterized protein. (1610 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (744 aa)
	RPS6KA3	Ribosomal protein S6 kinase. (732 aa)
	RPS6KA2	Non-specific serine/threonine protein kinase. (692 aa)
	TSC1	TSC complex subunit 1. (1164 aa)
	RICTOR	RPTOR independent companion of MTOR complex 2. (1709 aa)
	DDIT4	DNA damage inducible transcript 4. (232 aa)
	RHEBL1	RHEB like 1. (183 aa)
	ENSNLEP00000029688	Tankyrase_bdg_C domain-containing protein. (391 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1318 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
	ARHGAP8	Uncharacterized protein. (470 aa)
	MLST8	MTOR associated protein, LST8 homolog. (326 aa)
	EEF2K	Eukaryotic elongation factor 2 kinase. (725 aa)
	FKBP8	FKBP prolyl isomerase 8. (397 aa)
	TSC2	TSC complex subunit 2. (1777 aa)
	MAPKAP1	MAPK associated protein 1. (523 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1S1	DEPTOR	ENSNLEP00000006561	ENSNLEP00000006084	AKT1 substrate 1.	DEP domain containing MTOR interacting protein.	0.983
AKT1S1	ENSNLEP00000029688	ENSNLEP00000006561	ENSNLEP00000029688	AKT1 substrate 1.	Tankyrase_bdg_C domain-containing protein.	0.526
AKT1S1	FKBP8	ENSNLEP00000006561	ENSNLEP00000038356	AKT1 substrate 1.	FKBP prolyl isomerase 8.	0.832
AKT1S1	G1R844_NOMLE	ENSNLEP00000006561	ENSNLEP00000009378	AKT1 substrate 1.	Uncharacterized protein.	0.526
AKT1S1	MAPKAP1	ENSNLEP00000006561	ENSNLEP00000047528	AKT1 substrate 1.	MAPK associated protein 1.	0.975
AKT1S1	MLST8	ENSNLEP00000006561	ENSNLEP00000036779	AKT1 substrate 1.	MTOR associated protein, LST8 homolog.	0.999
AKT1S1	MTOR	ENSNLEP00000006561	ENSNLEP00000033904	AKT1 substrate 1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.996
AKT1S1	RHEB	ENSNLEP00000006561	ENSNLEP00000005480	AKT1 substrate 1.	Ras homolog, mTORC1 binding.	0.985
AKT1S1	RHEBL1	ENSNLEP00000006561	ENSNLEP00000021681	AKT1 substrate 1.	RHEB like 1.	0.553
AKT1S1	RICTOR	ENSNLEP00000006561	ENSNLEP00000019922	AKT1 substrate 1.	RPTOR independent companion of MTOR complex 2.	0.890
AKT1S1	RPS6KA1	ENSNLEP00000006561	ENSNLEP00000011368	AKT1 substrate 1.	Ribosomal protein S6 kinase.	0.456
AKT1S1	RPS6KB1	ENSNLEP00000006561	ENSNLEP00000000805	AKT1 substrate 1.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.972
AKT1S1	RPS6KB2	ENSNLEP00000006561	ENSNLEP00000007776	AKT1 substrate 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.593
AKT1S1	RPTOR	ENSNLEP00000006561	ENSNLEP00000030328	AKT1 substrate 1.	Regulatory associated protein of MTOR complex 1.	0.999
AKT1S1	TSC1	ENSNLEP00000006561	ENSNLEP00000015722	AKT1 substrate 1.	TSC complex subunit 1.	0.459
AKT1S1	TSC2	ENSNLEP00000006561	ENSNLEP00000039446	AKT1 substrate 1.	TSC complex subunit 2.	0.590
ARHGAP8	DEPTOR	ENSNLEP00000035320	ENSNLEP00000006084	Uncharacterized protein.	DEP domain containing MTOR interacting protein.	0.450
ARHGAP8	MAPKAP1	ENSNLEP00000035320	ENSNLEP00000047528	Uncharacterized protein.	MAPK associated protein 1.	0.792
ARHGAP8	MLST8	ENSNLEP00000035320	ENSNLEP00000036779	Uncharacterized protein.	MTOR associated protein, LST8 homolog.	0.792
ARHGAP8	MTOR	ENSNLEP00000035320	ENSNLEP00000033904	Uncharacterized protein.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.808

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