STRINGSTRING
ACVR1 ACVR1 SMAD9 SMAD9 GDF7 GDF7 INHBA INHBA BMP5 BMP5 GDF6 GDF6 TGFBR2 TGFBR2 ACVR2B ACVR2B SMAD1 SMAD1 LTBP3 LTBP3 MSTN MSTN BMP7 BMP7 ACVR2A ACVR2A BMP10 BMP10 GDF5 GDF5 TGFBR3 TGFBR3 FST FST RNF111 RNF111 BMP6 BMP6 SMAD4 SMAD4 BMP4 BMP4 ZFYVE16 ZFYVE16 TGFB1 TGFB1 LTBP4 LTBP4 BMP2 BMP2 BMPR1B BMPR1B TGFB2 TGFB2 SMURF2 SMURF2 GDF2 GDF2 TGFB3 TGFB3 BAMBI BAMBI INHBE INHBE INHBC INHBC GDF11 GDF11 AMHR2 AMHR2 ACVR1B ACVR1B ACVRL1 ACVRL1 ZFYVE9 ZFYVE9 SMAD2 SMAD2 ENG ENG BMPR1A BMPR1A ENSNLEP00000035372 ENSNLEP00000035372 TGFBR1 TGFBR1 SMAD3 SMAD3 BMPR2 BMPR2 NOG NOG GREM2 GREM2 SKIL SKIL SMAD5 SMAD5 SMURF1 SMURF1 SMAD7 SMAD7 SMAD6 SMAD6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
GDF7Growth differentiation factor 7. (450 aa)
INHBAInhibin subunit beta A. (426 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
GDF6Growth differentiation factor 6. (455 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
LTBP3Uncharacterized protein. (1148 aa)
MSTNMyostatin. (376 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
GDF5Growth differentiation factor 5. (442 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
FSTFollistatin. (317 aa)
RNF111Ring finger protein 111. (995 aa)
BMP6TGF_BETA_2 domain-containing protein. (125 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ZFYVE16Zinc finger FYVE-type containing 16. (1540 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1574 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SMURF2E3 ubiquitin-protein ligase. (745 aa)
GDF2Growth differentiation factor 2. (429 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (247 aa)
INHBEInhibin subunit beta E. (350 aa)
INHBCInhibin subunit beta C. (352 aa)
GDF11TGF_BETA_2 domain-containing protein. (377 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (573 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1421 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ENGEndoglin. (658 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
ENSNLEP00000035372TGF_BETA_2 domain-containing protein. (392 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
GREM2Gremlin. (168 aa)
SKILSKI like proto-oncogene. (683 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
SMURF1E3 ubiquitin-protein ligase. (749 aa)
SMAD7Mothers against decapentaplegic homolog. (376 aa)
SMAD6Mothers against decapentaplegic homolog. (465 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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