STRINGSTRING
STK4 STK4 LEF1 LEF1 NFATC4 NFATC4 NRARP NRARP KDR KDR RBM15 RBM15 DLL4 DLL4 TBX20 TBX20 ACVR1 ACVR1 EDN1 EDN1 TGFBR2 TGFBR2 PLEKHH1 PLEKHH1 SRF SRF PLXND1 PLXND1 EDNRA EDNRA CTNNB1 CTNNB1 SFRP2 SFRP2 NOTCH4 NOTCH4 COL4A1 COL4A1 IHH IHH GBX2 GBX2 GNA13 GNA13 FGF8 FGF8 GDF2 GDF2 NRP1 NRP1 ENG ENG PPP3R1 PPP3R1 SEMA3E SEMA3E
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STK4Serine/threonine kinase 4. (490 aa)
LEF1Lymphoid enhancer binding factor 1. (386 aa)
NFATC4Nuclear factor of activated T cells 4. (844 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
RBM15RNA binding motif protein 15. (977 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (692 aa)
TBX20T-box transcription factor 20. (447 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
EDN1Endothelin 1. (211 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PLEKHH1Pleckstrin homology, MyTH4 and FERM domain containing H1. (1318 aa)
SRFSerum response factor. (508 aa)
PLXND1Plexin D1. (1603 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CTNNB1Catenin beta 1. (781 aa)
SFRP2Secreted frizzled related protein 2. (280 aa)
NOTCH4Uncharacterized protein. (1913 aa)
COL4A1Collagen type IV alpha 1 chain. (1629 aa)
IHHIndian hedgehog signaling molecule. (389 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
GNA13G protein subunit alpha 13. (373 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
GDF2Growth differentiation factor 2. (429 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
ENGEndoglin. (658 aa)
PPP3R1Uncharacterized protein. (189 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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