STRINGSTRING
EPHB4 EPHB4 SEMA4B SEMA4B IQGAP1 IQGAP1 CAP1 CAP1 PTEN PTEN ADGRA2 ADGRA2 EDN2 EDN2 SEMA4A SEMA4A KANK2 KANK2 ABL1 ABL1 SMO SMO S100Z S100Z LPXN LPXN PDLIM1 PDLIM1 SEMA6B SEMA6B SNAI2 SNAI2 GIPC1 GIPC1 MIA3 MIA3 NRTN NRTN FERMT1 FERMT1 PROX1 PROX1 SEMA7A SEMA7A MYH9 MYH9 AMOT AMOT PMP22 PMP22 SEMA3C SEMA3C SEMA4G SEMA4G SEMA3A SEMA3A SEMA3D SEMA3D FGF8 FGF8 RADIL RADIL VSTM4 VSTM4 EGR3 EGR3 RET RET NODAL NODAL ARSJ ARSJ PTK2B PTK2B CYP1B1 CYP1B1 EDNRB EDNRB WNT11 WNT11 PKN3 PKN3 ITGB7 ITGB7 KRT2 KRT2 NR4A1 NR4A1 CLEC14A CLEC14A LOXL2 LOXL2 PPARD PPARD MEGF8 MEGF8 ENSNLEP00000024645 ENSNLEP00000024645 NRP1 NRP1 ENSNLEP00000024736 ENSNLEP00000024736 SOX10 SOX10 PKN1 PKN1 LOC100599403 LOC100599403 ENSNLEP00000026906 ENSNLEP00000026906 DAAM2 DAAM2 ENSNLEP00000027584 ENSNLEP00000027584 SEMA3E SEMA3E AKT1 AKT1 PHOX2B PHOX2B ENSNLEP00000028540 ENSNLEP00000028540 MIXL1 MIXL1 GDNF GDNF PHACTR4 PHACTR4 RAB13 RAB13 LRP5L LRP5L LRG1 LRG1 LOC100581752 LOC100581752 AMOTL1 AMOTL1 CORO1A CORO1A FOLR1 FOLR1 ENSNLEP00000031324 ENSNLEP00000031324 LAMTOR2 LAMTOR2 FAP FAP ENSNLEP00000033179 ENSNLEP00000033179 SEMA4C SEMA4C ARID5B ARID5B ENSNLEP00000034753 ENSNLEP00000034753 ADTRP ADTRP LOC100605369 LOC100605369 TNFSF12 TNFSF12 ZEB2 ZEB2 LOC100603674 LOC100603674 TESK1 TESK1 ENSNLEP00000036737 ENSNLEP00000036737 ENSNLEP00000037075 ENSNLEP00000037075 ANXA6 ANXA6 PTP4A3 PTP4A3 GIPC3 GIPC3 ENSNLEP00000038711 ENSNLEP00000038711 SEMA3B SEMA3B ROBO1 ROBO1 CDC42 CDC42 TGFBR1 TGFBR1 ENSNLEP00000041273 ENSNLEP00000041273 AMOTL2 AMOTL2 EFNB2 EFNB2 PIP5K1A PIP5K1A RIC8A RIC8A EDN3 EDN3 ENSNLEP00000041829 ENSNLEP00000041829 LAMA5 LAMA5 ZFAND5 ZFAND5 PML PML IRS2 IRS2 SGPL1 SGPL1 ENSNLEP00000045603 ENSNLEP00000045603 ENSNLEP00000045579 ENSNLEP00000045579 ARSB ARSB PIK3R3 PIK3R3 GPLD1 GPLD1 TPBG TPBG CER1 CER1 PLEC PLEC LOC100582927 LOC100582927 SEMA6A SEMA6A KDR KDR ROCK1 ROCK1 ENSNLEP00000043688 ENSNLEP00000043688 SCARB1 SCARB1 NRP2 NRP2 EMP2 EMP2 ENSNLEP00000042279 ENSNLEP00000042279 FUT8 FUT8 SEMA4F SEMA4F AQP1 AQP1 HIF1A HIF1A PITX2 PITX2 HTR2B HTR2B SLIT2 SLIT2 PXN PXN PTPN11 PTPN11 SEMA5B SEMA5B SEMA4D SEMA4D SRGAP2 SRGAP2 EFNB1 EFNB1 EDN1 EDN1 ACVR1 ACVR1 EPB41L5 EPB41L5 SOX17 SOX17 STARD13 STARD13 CALCA CALCA ITGB4 ITGB4 CLN3 CLN3 GPC3 GPC3 ANLN ANLN ITGB2 ITGB2 MMRN2 MMRN2 DPP4 DPP4 LGALS8 LGALS8 P2RY12 P2RY12 CDH5 CDH5 NOS3 NOS3 SRF SRF LGALS12 LGALS12 CCN3 CCN3 FSTL1 FSTL1 PLXND1 PLXND1 ALX1 ALX1 KITLG KITLG EDNRA EDNRA PIK3CA PIK3CA TDGF1 TDGF1 ITGA4 ITGA4 CORO1B CORO1B LRP5 LRP5 HAND2 HAND2 CORO1C CORO1C RHOA RHOA SEMA3F SEMA3F SNAI1 SNAI1 SEMA3G SEMA3G ERBB4 ERBB4 WNT5A WNT5A FN1 FN1 TNS1 TNS1 CXCL13 CXCL13 KIT KIT CCBE1 CCBE1 SOX8 SOX8 PLEKHG5 PLEKHG5 KANK1 KANK1 TMEM201 TMEM201 ID1 ID1 WASF2 WASF2 GIPC2 GIPC2 WDPCP WDPCP SEMA6C SEMA6C PKN2 PKN2 SOX18 SOX18 G1RH53_NOMLE G1RH53_NOMLE S100A2 S100A2 SLC9A3R1 SLC9A3R1 FGF19 FGF19 PAXIP1 PAXIP1 GBX2 GBX2 GREM1 GREM1 ISL1 ISL1 LOC100585005 LOC100585005 KRT16 KRT16 FAT2 FAT2 TBXT TBXT SEMA5A SEMA5A MESP1 MESP1 S100P S100P
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EPHB4EPH receptor B4. (890 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (836 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
CAP1Adenylyl cyclase-associated protein; Belongs to the CAP family. (475 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1128 aa)
EDN2Endothelin 2. (177 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (758 aa)
KANK2KN motif and ankyrin repeat domains 2. (788 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (683 aa)
S100ZProtein S100; Belongs to the S-100 family. (99 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (387 aa)
PDLIM1PDZ and LIM domain 1. (329 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (857 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
GIPC1PDZ domain-containing protein. (225 aa)
MIA3MIA SH3 domain ER export factor 3. (1910 aa)
NRTNNeurturin. (197 aa)
FERMT1Fermitin family member 1. (587 aa)
PROX1Prospero homeobox 1. (737 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1975 aa)
AMOTAngiomotin. (1088 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (793 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (771 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
RADILRap associating with DIL domain. (1034 aa)
VSTM4V-set and transmembrane domain containing 4. (320 aa)
EGR3Early growth response 3. (387 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
NODALNodal growth differentiation factor. (347 aa)
ARSJArylsulfatase family member J. (597 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PKN3Protein kinase N3. (895 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (799 aa)
KRT2Keratin 2; Belongs to the intermediate filament family. (629 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (589 aa)
CLEC14AC-type lectin domain containing 14A. (490 aa)
LOXL2Lysyl oxidase like 2. (710 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
MEGF8Multiple EGF like domains 8. (2574 aa)
ENSNLEP00000024645GFA domain-containing protein. (272 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
ENSNLEP00000024736Uncharacterized protein. (489 aa)
SOX10HMG box domain-containing protein. (236 aa)
PKN1Protein kinase domain-containing protein. (839 aa)
LOC100599403PIPK domain-containing protein. (591 aa)
ENSNLEP00000026906Hr1 domain-containing protein. (311 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1012 aa)
ENSNLEP00000027584SH2 domain-containing protein. (188 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
ENSNLEP00000028540Uncharacterized protein. (311 aa)
MIXL1Mix paired-like homeobox. (232 aa)
GDNFTGF_BETA_2 domain-containing protein. (169 aa)
PHACTR4Phosphatase and actin regulator. (512 aa)
RAB13Uncharacterized protein. (203 aa)
LRP5LUncharacterized protein. (150 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
LOC100581752Adenylyl cyclase-associated protein; Belongs to the CAP family. (423 aa)
AMOTL1Angiomotin like 1. (962 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
FOLR1Folate receptor alpha. (228 aa)
ENSNLEP00000031324Uncharacterized protein. (255 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
ENSNLEP00000033179Adenylyl cyclase-associated protein; Belongs to the CAP family. (407 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
ARID5BAT-rich interaction domain 5B. (1187 aa)
ENSNLEP00000034753Uncharacterized protein. (428 aa)
ADTRPAndrogen dependent TFPI regulating protein. (248 aa)
LOC100605369Uncharacterized protein. (571 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (249 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1253 aa)
LOC100603674Uncharacterized protein. (371 aa)
TESK1Testis associated actin remodelling kinase 1. (620 aa)
ENSNLEP00000036737Uncharacterized protein. (160 aa)
ENSNLEP00000037075Uncharacterized protein. (572 aa)
ANXA6Annexin. (673 aa)
PTP4A3Protein tyrosine phosphatase 4A3. (173 aa)
GIPC3GIPC PDZ domain containing family member 3. (284 aa)
ENSNLEP00000038711CFC domain-containing protein. (158 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (770 aa)
ROBO1Roundabout guidance receptor 1. (1651 aa)
CDC42Cell division cycle 42. (191 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
ENSNLEP00000041273Uncharacterized protein. (190 aa)
AMOTL2Angiomotin like 2. (780 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (299 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
RIC8ARIC8 guanine nucleotide exchange factor A. (536 aa)
EDN3Uncharacterized protein. (211 aa)
ENSNLEP00000041829PIPK domain-containing protein. (329 aa)
LAMA5Laminin subunit alpha 5. (3418 aa)
ZFAND5Zinc finger AN1-type containing 5. (213 aa)
PMLUncharacterized protein. (873 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
ENSNLEP00000045603Uncharacterized protein. (252 aa)
ENSNLEP00000045579Adenylyl cyclase-associated protein; Belongs to the CAP family. (436 aa)
ARSBArylsulfatase B. (535 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (840 aa)
TPBGTrophoblast glycoprotein. (384 aa)
CER1Cerberus 1, DAN family BMP antagonist. (267 aa)
PLECPlectin. (4280 aa)
LOC100582927Protein kinase domain-containing protein. (934 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
ENSNLEP00000043688Uncharacterized protein. (273 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (550 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
ENSNLEP00000042279Uncharacterized protein. (587 aa)
FUT8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (575 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (683 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
PITX2Homeobox protein. (420 aa)
HTR2BG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (398 aa)
SLIT2Slit guidance ligand 2. (1389 aa)
PXNUncharacterized protein. (1078 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
SEMA5BSemaphorin 5B. (1090 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
SRGAP2Uncharacterized protein. (1016 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
EDN1Endothelin 1. (211 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (732 aa)
SOX17SRY-box transcription factor 17. (410 aa)
STARD13StAR related lipid transfer domain containing 13. (930 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
ITGB4Integrin beta. (1746 aa)
CLN3Battenin. (384 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
ANLNAnillin actin binding protein. (1129 aa)
ITGB2Integrin beta. (762 aa)
MMRN2Multimerin 2. (949 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (766 aa)
LGALS8Galectin. (359 aa)
P2RY12Purinergic receptor P2Y12. (342 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (687 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
SRFSerum response factor. (508 aa)
LGALS12Galectin. (337 aa)
CCN3Cellular communication network factor 3. (357 aa)
FSTL1Follistatin like 1. (306 aa)
PLXND1Plexin D1. (1603 aa)
ALX1ALX homeobox 1. (326 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (481 aa)
LRP5LDL receptor related protein 5. (1510 aa)
HAND2Heart and neural crest derivatives expressed 2. (198 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (444 aa)
RHOARas homolog family member A. (193 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (788 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (782 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FN1Fibronectin 1. (2477 aa)
TNS1Tensin 1. (1696 aa)
CXCL13C-X-C motif chemokine ligand 13. (109 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (969 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
SOX8SRY-box transcription factor 8. (446 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1009 aa)
KANK1KN motif and ankyrin repeat domains 1. (1352 aa)
TMEM201Transmembrane protein 201. (637 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (155 aa)
WASF2WH2 domain-containing protein. (401 aa)
GIPC2GIPC PDZ domain containing family member 2. (287 aa)
WDPCPWD repeat containing planar cell polarity effector. (746 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (921 aa)
PKN2Uncharacterized protein. (984 aa)
SOX18SRY-box transcription factor 18. (362 aa)
G1RH53_NOMLESulfatase domain-containing protein. (410 aa)
S100A2Protein S100; Belongs to the S-100 family. (97 aa)
SLC9A3R1Uncharacterized protein. (276 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PAXIP1PAX interacting protein 1. (1059 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
GREM1CTCK domain-containing protein. (143 aa)
ISL1ISL LIM homeobox 1. (349 aa)
LOC100585005IF rod domain-containing protein; Belongs to the intermediate filament family. (379 aa)
KRT16Keratin 16; Belongs to the intermediate filament family. (476 aa)
FAT2FAT atypical cadherin 2. (4345 aa)
TBXTT-box transcription factor T. (435 aa)
SEMA5ASemaphorin 5A. (1074 aa)
MESP1Uncharacterized protein. (170 aa)
S100PS100 calcium binding protein P. (95 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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