(73 nodes) Photoreceptor inner segment network (Nomascus leucogenys)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZBED4	Zinc finger BED-type containing 4. (1171 aa)
	ENSNLEP00000025821	FERM_f0 domain-containing protein. (129 aa)
	STX3	Syntaxin 3; Belongs to the syntaxin family. (251 aa)
	ARMS2	Age-related maculopathy susceptibility 2. (106 aa)
	CDH23	Cadherin related 23. (3327 aa)
	RS1	Retinoschisin 1. (224 aa)
	INHA	Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
	AIPL1	Aryl hydrocarbon receptor interacting protein like 1. (384 aa)
	PPEF2	Serine/threonine-protein phosphatase with EF-hands. (757 aa)
	CCDC66	Coiled-coil domain containing 66. (925 aa)
	GNAT1	G protein subunit alpha transducin 1. (339 aa)
	CERKL	Ceramide kinase like. (559 aa)
	RHO	Rhodopsin. (348 aa)
	MYO3B	Myosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1341 aa)
	GUCA1A	Uncharacterized protein. (201 aa)
	GUCA1B	Guanylate cyclase activator 1B. (166 aa)
	PRPH2	Peripherin 2. (346 aa)
	DHRS12	Dehydrogenase/reductase 12. (317 aa)
	DRAM2	DNA damage regulated autophagy modulator 2. (266 aa)
	ASRGL1	Asparaginase and isoaspartyl peptidase 1. (313 aa)
	GNAT2	G protein subunit alpha transducin 2. (354 aa)
	RP1	Uncharacterized protein. (2042 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (732 aa)
	RDH12	Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
	RDH11	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa)
	BSG	Uncharacterized protein. (345 aa)
	USH1G	USH1 protein network component sans. (452 aa)
	NOS1	Nitric oxide synthase; Produces nitric oxide (NO). (1425 aa)
	CRB2	Uncharacterized protein. (1063 aa)
	SLC24A2	Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (661 aa)
	FAM161A	FAM161 centrosomal protein A. (716 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
	RCVRN	Recoverin. (200 aa)
	CEP250	Centrosomal protein 250. (2422 aa)
	SLC2A1	Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (462 aa)
	OPN1SW	Opsin 1, short wave sensitive. (348 aa)
	PIP4K2A	Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (371 aa)
	CROCC	Ciliary rootlet coiled-coil, rootletin. (1915 aa)
	KIAA0586	KIAA0586. (1633 aa)
	ATP1A3	Sodium/potassium-transporting ATPase subunit alpha. (952 aa)
	USP45	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (816 aa)
	ADGRV1	Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family. (6305 aa)
	BBS4	Bardet-Biedl syndrome 4. (518 aa)
	USH2A	Usherin. (5203 aa)
	SNAP25	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
	GNAT3	G protein subunit alpha transducin 3. (354 aa)
	PCARE	Photoreceptor cilium actin regulator. (1270 aa)
	GNGT1	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
	MYO7A	Myosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2083 aa)
	MYO3A	Myosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1609 aa)
	WHRN	Whirlin. (819 aa)
	IMPG1	Interphotoreceptor matrix proteoglycan 1. (753 aa)
	ATP1A1	Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
	LOC100593615	TPR_REGION domain-containing protein. (160 aa)
	ENO2	Enolase 2. (434 aa)
	SHANK2	SH3 and multiple ankyrin repeat domains 2. (1261 aa)
	SAG	S-antigen visual arrestin. (405 aa)
	ENSNLEP00000037777	Uncharacterized protein. (246 aa)
	DNM1	Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (827 aa)
	PHLPP2	PH domain and leucine rich repeat protein phosphatase 2. (1317 aa)
	RD3	Retinal degeneration 3, GUCY2D regulator. (195 aa)
	MAK	Male germ cell associated kinase. (648 aa)
	ARR3	Arrestin 3. (389 aa)
	C8orf37	Chromosome 8 open reading frame 37. (207 aa)
	ENSNLEP00000046992	Receptor expression-enhancing protein. (210 aa)
	KIFAP3	Kinesin associated protein 3. (794 aa)
	CROCC2	Ciliary rootlet coiled-coil, rootletin family member 2. (1571 aa)
	GUK1	Guanylate kinase-like domain-containing protein. (272 aa)
	ENSNLEP00000048128	Uncharacterized protein. (950 aa)
	CIB2	Calcium and integrin binding family member 2. (187 aa)
	USH1C	USH1 protein network component harmonin. (877 aa)
	PDC	Phosducin. (246 aa)
	CRB1	Crumbs cell polarity complex component 1. (1406 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRV1	CDH23	ENSNLEP00000016851	ENSNLEP00000029204	Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family.	Cadherin related 23.	0.832
ADGRV1	CIB2	ENSNLEP00000016851	ENSNLEP00000048242	Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family.	Calcium and integrin binding family member 2.	0.535
ADGRV1	MYO7A	ENSNLEP00000016851	ENSNLEP00000020340	Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family.	Myosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.806
ADGRV1	USH1C	ENSNLEP00000016851	ENSNLEP00000021528	Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family.	USH1 protein network component harmonin.	0.798
ADGRV1	USH1G	ENSNLEP00000016851	ENSNLEP00000000595	Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family.	USH1 protein network component sans.	0.784
ADGRV1	USH2A	ENSNLEP00000016851	ENSNLEP00000017374	Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family.	Usherin.	0.833
ADGRV1	WHRN	ENSNLEP00000016851	ENSNLEP00000020439	Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family.	Whirlin.	0.947
AIPL1	CERKL	ENSNLEP00000011145	ENSNLEP00000007684	Aryl hydrocarbon receptor interacting protein like 1.	Ceramide kinase like.	0.479
AIPL1	GUCA1A	ENSNLEP00000011145	ENSNLEP00000005824	Aryl hydrocarbon receptor interacting protein like 1.	Uncharacterized protein.	0.497
AIPL1	GUCA1B	ENSNLEP00000011145	ENSNLEP00000005819	Aryl hydrocarbon receptor interacting protein like 1.	Guanylate cyclase activator 1B.	0.567
AIPL1	PRPH2	ENSNLEP00000011145	ENSNLEP00000005678	Aryl hydrocarbon receptor interacting protein like 1.	Peripherin 2.	0.628
AIPL1	RCVRN	ENSNLEP00000011145	ENSNLEP00000012323	Aryl hydrocarbon receptor interacting protein like 1.	Recoverin.	0.421
AIPL1	RD3	ENSNLEP00000011145	ENSNLEP00000040456	Aryl hydrocarbon receptor interacting protein like 1.	Retinal degeneration 3, GUCY2D regulator.	0.672
AIPL1	RDH12	ENSNLEP00000011145	ENSNLEP00000001014	Aryl hydrocarbon receptor interacting protein like 1.	Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.685
AIPL1	RHO	ENSNLEP00000011145	ENSNLEP00000006394	Aryl hydrocarbon receptor interacting protein like 1.	Rhodopsin.	0.449
ARR3	DNM1	ENSNLEP00000043372	ENSNLEP00000038165	Arrestin 3.	Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.427
ARR3	ENSNLEP00000046992	ENSNLEP00000043372	ENSNLEP00000046992	Arrestin 3.	Receptor expression-enhancing protein.	0.459
ARR3	GNAT1	ENSNLEP00000043372	ENSNLEP00000008477	Arrestin 3.	G protein subunit alpha transducin 1.	0.505
ARR3	GNAT2	ENSNLEP00000043372	ENSNLEP00000003647	Arrestin 3.	G protein subunit alpha transducin 2.	0.534
ARR3	GNGT1	ENSNLEP00000043372	ENSNLEP00000018729	Arrestin 3.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.612

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