STRINGSTRING
PDGFB PDGFB VIP VIP GDF2 GDF2 PRKD1 PRKD1 EGR3 EGR3 TEK TEK EGF EGF VEGFC VEGFC JCAD JCAD SP1 SP1 NR4A1 NR4A1 ACVRL1 ACVRL1 AKT3 AKT3 AGGF1 AGGF1 M3ZBW0_NOMLE M3ZBW0_NOMLE NRP1 NRP1 PPP1R16B PPP1R16B AKT1 AKT1 FGF10 FGF10 LRG1 LRG1 IGF2 IGF2 RPTOR RPTOR ITGB3 ITGB3 PGF PGF IL10 IL10 VEGFA VEGFA TNFSF12 TNFSF12 CXCL12 CXCL12 NF1 NF1 NRAS NRAS LOC100593010 LOC100593010 TGFBR1 TGFBR1 NRARP NRARP MYDGF MYDGF BMPR2 BMPR2 NRP2 NRP2 AGTR1 AGTR1 KDR KDR HMOX1 HMOX1 PLXNB3 PLXNB3 HTR2B HTR2B LOC100595279 LOC100595279 HIF1A HIF1A PRKCA PRKCA CCL11 CCL11 FLT4 FLT4 PRKD2 PRKD2 SIRT6 SIRT6 PROK1 PROK1 GHRL GHRL VEGFB VEGFB GHSR GHSR EMC10 EMC10 CCR3 CCR3 FGF7 FGF7 ITGA4 ITGA4 PLCG1 PLCG1 WNT5A WNT5A CCL24 CCL24 CCL26 CCL26 PIK3CD PIK3CD VEGFD VEGFD LOC100592336 LOC100592336 SCG2 SCG2 ECM1 ECM1 ARNT ARNT F3 F3 CAV2 CAV2 STAT3 STAT3 SEMA5A SEMA5A BMP6 BMP6 SIRT1 SIRT1 FGFR1 FGFR1 APLNR APLNR BMP4 BMP4 THBS4 THBS4 ADAM17 ADAM17 BMP2 BMP2 GATA2 GATA2 ARG1 ARG1 PROX1 PROX1 VASH2 VASH2 JUN JUN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
VIPVasoactive intestinal peptide. (170 aa)
GDF2Growth differentiation factor 2. (429 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
EGR3Early growth response 3. (387 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
JCADJunctional cadherin 5 associated. (1354 aa)
SP1Sp1 transcription factor. (786 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (589 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AGGF1G-patch domain-containing protein. (679 aa)
M3ZBW0_NOMLESH2 domain-containing protein. (230 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (562 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
IGF2IlGF domain-containing protein. (180 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1318 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (225 aa)
IL10Interleukin 10. (178 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (393 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (249 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
NF1Neurofibromin 1. (2839 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
MYDGFMyeloid derived growth factor. (188 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
PLXNB3Plexin B3. (1842 aa)
HTR2BG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (398 aa)
LOC100595279Uncharacterized protein. (212 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
CCL11C-C motif chemokine. (97 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
PRKD2Uncharacterized protein. (716 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (215 aa)
PROK1Prokineticin 1. (105 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
EMC10Uncharacterized protein. (347 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (361 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
CCL24C-C motif chemokine ligand 24. (118 aa)
CCL26C-C motif chemokine. (94 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1077 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
SCG2Secretogranin II. (542 aa)
ECM1Extracellular matrix protein 1. (568 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (295 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (86 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SEMA5ASemaphorin 5A. (1074 aa)
BMP6TGF_BETA_2 domain-containing protein. (125 aa)
SIRT1Sirtuin 1. (734 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
THBS4Thrombospondin 4. (925 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
GATA2GATA binding protein 2. (480 aa)
ARG1Arginase. (322 aa)
PROX1Prospero homeobox 1. (737 aa)
VASH2Uncharacterized protein. (251 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (305 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.