STRINGSTRING
MESD MESD SYK SYK DOCK1 DOCK1 NOD2 NOD2 ELANE ELANE EIF2AK1 EIF2AK1 XKR4 XKR4 ABCA7 ABCA7 LYN LYN ANXA1 ANXA1 VAV3 VAV3 CLN3 CLN3 MERTK MERTK UNC13D UNC13D ADGRB1 ADGRB1 RARA RARA TAFA4 TAFA4 MSR1 MSR1 ITGB2 ITGB2 ELMO1 ELMO1 RAB34 RAB34 LYST LYST CRYBA1 CRYBA1 TYRO3 TYRO3 TIMD4 TIMD4 MYO1G MYO1G ELMO3 ELMO3 TREM2 TREM2 MYD88 MYD88 PIK3CA PIK3CA TGM2 TGM2 GULP1 GULP1 CORO1C CORO1C COLEC12 COLEC12 YES1 YES1 MST1R MST1R TUSC2 TUSC2 PRKCD PRKCD ICAM5 ICAM5 PLA2G5 PLA2G5 RAB20 RAB20 G1R9T9_NOMLE G1R9T9_NOMLE ANXA3 ANXA3 SLC11A1 SLC11A1 TULP1 TULP1 FCN2 FCN2 CD14 CD14 FCN3 FCN3 XKR8 XKR8 HCK HCK ARHGAP25 ARHGAP25 GAS6 GAS6 ANXA11 ANXA11 XKR9 XKR9 IRF8 IRF8 MFGE8 MFGE8 CD93 CD93 BECN1 BECN1 RHOBTB1 RHOBTB1 MEGF10 MEGF10 LEP LEP VPS33B VPS33B ABL1 ABL1 PEAR1 PEAR1 G1RT88_NOMLE G1RT88_NOMLE GATA2 GATA2 MYH9 MYH9 G1RX97_NOMLE G1RX97_NOMLE XKR5 XKR5 CEBPE CEBPE G1RYD7_NOMLE G1RYD7_NOMLE PECAM1 PECAM1 ADORA2A ADORA2A RAC1 RAC1 ITGAL ITGAL P2RX7 P2RX7 ITGAM ITGAM MYO7A MYO7A PRKCE PRKCE MORN5 MORN5 ABCA1 ABCA1 ALOX15 ALOX15 PLD2 PLD2 BIN2 BIN2 NCF2 NCF2 PIKFYVE PIKFYVE M3Z9E6_NOMLE M3Z9E6_NOMLE CDC42SE2 CDC42SE2 RAB7A RAB7A LOC100599403 LOC100599403 RAB11FIP2 RAB11FIP2 SRPX SRPX VAV1 VAV1 NR1H3 NR1H3 TM9SF4 TM9SF4 VAMP7 VAMP7 ENSNLEP00000027935 ENSNLEP00000027935 DNM2 DNM2 RAB39A RAB39A VIPAS39 VIPAS39 XKR7 XKR7 ENSNLEP00000030682 ENSNLEP00000030682 CORO1A CORO1A ITGB3 ITGB3 PRTN3 PRTN3 SPG11 SPG11 C1orf43 C1orf43 FGR FGR ELMO2 ELMO2 PTK2 PTK2 ENSNLEP00000034515 ENSNLEP00000034515 SLAMF1 SLAMF1 ICAM3 ICAM3 CLEC7A CLEC7A ENSNLEP00000035523 ENSNLEP00000035523 ITGAV ITGAV LIMK1 LIMK1 ENSNLEP00000036049 ENSNLEP00000036049 RHOG RHOG PLA2G6 PLA2G6 FCN1 FCN1 ENSNLEP00000037391 ENSNLEP00000037391 ARL8B ARL8B LEPR LEPR TMEM175 TMEM175 LRP1 LRP1 ENSNLEP00000038540 ENSNLEP00000038540 SYT7 SYT7 RHOBTB2 RHOBTB2 LDLR LDLR ARHGAP12 ARHGAP12 TUB TUB PAK1 PAK1 ENSNLEP00000039713 ENSNLEP00000039713 FCGR2B FCGR2B CDC42SE1 CDC42SE1 PLPP4 PLPP4 JMJD6 JMJD6 GSN GSN TYROBP TYROBP CDC42 CDC42 P2RY6 P2RY6 FYN FYN PIP5K1A PIP5K1A ENSNLEP00000041829 ENSNLEP00000041829 RAC2 RAC2 ENSNLEP00000042609 ENSNLEP00000042609 ENSNLEP00000043131 ENSNLEP00000043131 KIAA1109 KIAA1109 SCARB1 SCARB1 THBS1 THBS1 ENSNLEP00000044067 ENSNLEP00000044067 CD36 CD36 ENSNLEP00000045542 ENSNLEP00000045542 PIP5K1C PIP5K1C BCR BCR HAVCR1 HAVCR1 RUBCN RUBCN VAV2 VAV2 AXL AXL AIF1 AIF1 SRC SRC CD302 CD302
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MESDMesoderm development LRP chaperone. (220 aa)
SYKTyrosine-protein kinase. (532 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (239 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (614 aa)
XKR4XK-related protein. (469 aa)
ABCA7Uncharacterized protein. (1829 aa)
LYNTyrosine-protein kinase. (512 aa)
ANXA1Annexin. (346 aa)
VAV3Vav guanine nucleotide exchange factor 3. (799 aa)
CLN3Battenin. (384 aa)
MERTKMER proto-oncogene, tyrosine kinase. (991 aa)
UNC13DUnc-13 homolog D. (1082 aa)
ADGRB1Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1489 aa)
RARARetinoic acid receptor alpha. (458 aa)
TAFA4TAFA chemokine like family member 4. (140 aa)
MSR1Macrophage scavenger receptor 1. (469 aa)
ITGB2Integrin beta. (762 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
RAB34RAB34, member RAS oncogene family. (268 aa)
LYSTLysosomal trafficking regulator. (3801 aa)
CRYBA1Crystallin beta A1; Belongs to the beta/gamma-crystallin family. (215 aa)
TYRO3TYRO3 protein tyrosine kinase. (760 aa)
TIMD4T cell immunoglobulin and mucin domain containing 4. (378 aa)
MYO1GMyosin IG; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1013 aa)
ELMO3Engulfment and cell motility 3. (694 aa)
TREM2Ig-like domain-containing protein. (222 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
TGM2Transglutaminase 2. (668 aa)
GULP1GULP PTB domain containing engulfment adaptor 1. (304 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (444 aa)
COLEC12Collectin subfamily member 12. (742 aa)
YES1Tyrosine-protein kinase. (519 aa)
MST1RMacrophage stimulating 1 receptor. (1312 aa)
TUSC2Tumor suppressor 2, mitochondrial calcium regulator. (110 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
ICAM5Uncharacterized protein. (562 aa)
PLA2G5Phospholipase A(2). (138 aa)
RAB20RAB20, member RAS oncogene family. (234 aa)
G1R9T9_NOMLEUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (784 aa)
ANXA3Annexin. (323 aa)
SLC11A1Solute carrier family 11 member 1. (550 aa)
TULP1Tubby-like protein; Belongs to the TUB family. (572 aa)
FCN2Ficolin 2. (313 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
FCN3Ficolin 3. (299 aa)
XKR8XK-related protein. (350 aa)
HCKTyrosine-protein kinase. (525 aa)
ARHGAP25Rho GTPase activating protein 25. (606 aa)
GAS6Growth arrest specific 6. (679 aa)
ANXA11Annexin. (465 aa)
XKR9XK-related protein. (373 aa)
IRF8Interferon regulatory factor 8. (426 aa)
MFGE8Milk fat globule-EGF factor 8 protein. (374 aa)
CD93CD93 molecule. (651 aa)
BECN1Beclin 1. (450 aa)
RHOBTB1Rho related BTB domain containing 1. (696 aa)
MEGF10Multiple EGF like domains 10. (1140 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
VPS33BUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (617 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
PEAR1Platelet endothelial aggregation receptor 1. (1035 aa)
G1RT88_NOMLEIGv domain-containing protein. (232 aa)
GATA2GATA binding protein 2. (480 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1975 aa)
G1RX97_NOMLEUncharacterized protein. (247 aa)
XKR5XK-related protein. (686 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
G1RYD7_NOMLEXK-related protein. (550 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (721 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
RAC1Rac family small GTPase 1. (187 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1142 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (992 aa)
MYO7AMyosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2083 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
MORN5MORN repeat containing 5. (161 aa)
ABCA1ATP binding cassette subfamily A member 1. (2254 aa)
ALOX15Arachidonate 15-lipoxygenase. (662 aa)
PLD2Phospholipase. (933 aa)
BIN2Bridging integrator 2. (542 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa)
M3Z9E6_NOMLEIg-like domain-containing protein. (148 aa)
CDC42SE2CDC42 small effector 2. (84 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
LOC100599403PIPK domain-containing protein. (591 aa)
RAB11FIP2RAB11 family interacting protein 2. (532 aa)
SRPXSushi repeat containing protein X-linked. (457 aa)
VAV1Uncharacterized protein. (739 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (466 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (642 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (260 aa)
ENSNLEP00000027935Uncharacterized protein. (181 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (770 aa)
RAB39ARAB39A, member RAS oncogene family. (217 aa)
VIPAS39VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog. (519 aa)
XKR7XK-related protein. (579 aa)
ENSNLEP00000030682Ig-like domain-containing protein. (159 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
PRTN3Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (160 aa)
SPG11SPG11 vesicle trafficking associated, spatacsin. (2443 aa)
C1orf43Chromosome 1 open reading frame 43. (253 aa)
FGRTyrosine-protein kinase. (476 aa)
ELMO2Engulfment and cell motility 2. (720 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1099 aa)
ENSNLEP00000034515Uncharacterized protein. (171 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (331 aa)
ICAM3Uncharacterized protein. (446 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
ENSNLEP00000035523Uncharacterized protein. (199 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1008 aa)
LIMK1Uncharacterized protein. (614 aa)
ENSNLEP00000036049Ig-like domain-containing protein. (299 aa)
RHOGRas homolog family member G. (191 aa)
PLA2G6Phospholipase A2 group VI. (805 aa)
FCN1Ficolin 1. (326 aa)
ENSNLEP00000037391Uncharacterized protein. (52 aa)
ARL8BADP ribosylation factor like GTPase 8B; Belongs to the small GTPase superfamily. Arf family. (186 aa)
LEPRLeptin receptor. (1165 aa)
TMEM175Uncharacterized protein. (74 aa)
LRP1LDL receptor related protein 1. (4219 aa)
ENSNLEP00000038540Uncharacterized protein. (347 aa)
SYT7Uncharacterized protein. (592 aa)
RHOBTB2Rho related BTB domain containing 2. (749 aa)
LDLRUncharacterized protein. (839 aa)
ARHGAP12Rho GTPase activating protein 12. (846 aa)
TUBTubby-like protein; Belongs to the TUB family. (560 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
ENSNLEP00000039713Ig-like domain-containing protein. (361 aa)
FCGR2BUncharacterized protein. (310 aa)
CDC42SE1CDC42 small effector 1. (79 aa)
PLPP4Phospholipid phosphatase 4. (279 aa)
JMJD6JmjC domain-containing protein. (249 aa)
GSNGelsolin. (814 aa)
TYROBPUncharacterized protein. (144 aa)
CDC42Cell division cycle 42. (191 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
FYNTyrosine-protein kinase. (537 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
ENSNLEP00000041829PIPK domain-containing protein. (329 aa)
RAC2Rac family small GTPase 2. (192 aa)
ENSNLEP00000042609Uncharacterized protein. (168 aa)
ENSNLEP00000043131Ig-like domain-containing protein. (186 aa)
KIAA1109KIAA1109. (4964 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (550 aa)
THBS1Thrombospondin 1. (1173 aa)
ENSNLEP00000044067Uncharacterized protein. (108 aa)
CD36CD36 molecule; Belongs to the CD36 family. (433 aa)
ENSNLEP00000045542Ig-like domain-containing protein. (115 aa)
PIP5K1CPIPK domain-containing protein. (759 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
HAVCR1Ig-like domain-containing protein. (360 aa)
RUBCNRubicon autophagy regulator. (966 aa)
VAV2Vav guanine nucleotide exchange factor 2. (788 aa)
AXLReceptor protein-tyrosine kinase. (860 aa)
AIF1Allograft inflammatory factor 1. (161 aa)
SRCTyrosine-protein kinase. (537 aa)
CD302CD302 molecule. (232 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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