STRINGSTRING
NOS3 NOS3 ETV6 ETV6 SRC SRC PLK1 PLK1 SIRT1 SIRT1 TTK TTK GDF9 GDF9 C19orf57 C19orf57 STRA8 STRA8 PLD6 PLD6 MCM9 MCM9 C14orf39 C14orf39 BMPR1B BMPR1B METTL3 METTL3 DMC1 DMC1 REC8 REC8 PIWIL2 PIWIL2 TDRD5 TDRD5 SPIRE2 SPIRE2 TDRD1 TDRD1 PTK2B PTK2B MLH3 MLH3 SOS1 SOS1 MASTL MASTL RPS6 RPS6 MMP19 MMP19 KMT2D KMT2D TUT4 TUT4 PTGS2 PTGS2 RGS2 RGS2 ASPM ASPM ZNF830 ZNF830 TRIM75P TRIM75P LOC100585954 LOC100585954 PAQR6 PAQR6 MEIKIN MEIKIN PTN PTN MTHFSD MTHFSD NRIP1 NRIP1 ENSNLEP00000027485 ENSNLEP00000027485 LOC100593129 LOC100593129 IMMP2L IMMP2L M1AP M1AP ENSNLEP00000029497 ENSNLEP00000029497 ENSNLEP00000029686 ENSNLEP00000029686 AURKC AURKC SEPTIN1 SEPTIN1 MEI4 MEI4 ZGLP1 ZGLP1 PTX3 PTX3 TDRD6 TDRD6 PDE3A PDE3A MLH1 MLH1 CCDC155 CCDC155 TUT7 TUT7 MEIOC MEIOC HROB HROB EDNRA EDNRA CTNNB1 CTNNB1 FOSL1 FOSL1 BCL2L10 BCL2L10 TAF4B TAF4B HPGD HPGD CCDC36 CCDC36 NDC80 NDC80 AURKA AURKA SPO11 SPO11 PGR PGR ATM ATM AFP AFP EREG EREG YBX2 YBX2 BMP15 BMP15 ZP3 ZP3 RAD51C RAD51C DMRT1 DMRT1 FSHR FSHR MEIOB MEIOB G1RC35_NOMLE G1RC35_NOMLE SPIRE1 SPIRE1 IHH IHH PDE5A PDE5A YTHDC1 YTHDC1 MSH4 MSH4 SYCP2 SYCP2 HORMAD1 HORMAD1 FIGLA FIGLA TDRKH TDRKH ZMIZ1 ZMIZ1 TNFAIP6 TNFAIP6 TRIP13 TRIP13 TDRD10 TDRD10 RPS6KA2 RPS6KA2 CCNB2 CCNB2 IL4R IL4R LOC100580067 LOC100580067 YTHDC2 YTHDC2 AMH AMH TDRD15 TDRD15 PAQR8 PAQR8 DDX20 DDX20 ENSNLEP00000038023 ENSNLEP00000038023 HEXB HEXB PPP2R1A PPP2R1A BCL2 BCL2 CDC25B CDC25B WDR77 WDR77 ENSNLEP00000035372 ENSNLEP00000035372 MARF1 MARF1 NPM2 NPM2 ENSNLEP00000033171 ENSNLEP00000033171 PAQR5 PAQR5 ENSNLEP00000047907 ENSNLEP00000047907 YTHDF2 YTHDF2 EHMT2 EHMT2 ENSNLEP00000046801 ENSNLEP00000046801 PRDM9 PRDM9 NANOS3 NANOS3 LGR5 LGR5 FBXO5 FBXO5 HSF2BP HSF2BP ENSNLEP00000043395 ENSNLEP00000043395 ENSNLEP00000043394 ENSNLEP00000043394 PABPC1L PABPC1L GAS2 GAS2 ENSNLEP00000042687 ENSNLEP00000042687 LOC100600765 LOC100600765 NCAPH NCAPH LOC100587270 LOC100587270 EDN1 EDN1 NCAPH2 NCAPH2 DIAPH2 DIAPH2 BRCA2 BRCA2 MMP2 MMP2 TOP2A TOP2A ERCC1 ERCC1 SEBOX SEBOX BHMG1 BHMG1 WEE2 WEE2 ADAMTS1 ADAMTS1 NOBOX NOBOX FMN2 FMN2 GPR149 GPR149
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
ETV6ETS variant 6. (477 aa)
SRCTyrosine-protein kinase. (537 aa)
PLK1Serine/threonine-protein kinase PLK. (568 aa)
SIRT1Sirtuin 1. (734 aa)
TTKTTK protein kinase. (852 aa)
GDF9Growth differentiation factor 9. (455 aa)
C19orf57Chromosome 19 open reading frame 57. (637 aa)
STRA8Stimulated by retinoic acid 8. (329 aa)
PLD6PLD phosphodiesterase domain-containing protein. (252 aa)
MCM9MCM domain-containing protein; Belongs to the MCM family. (391 aa)
C14orf39Chromosome 14 open reading frame 39. (587 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
REC8REC8 meiotic recombination protein. (541 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (925 aa)
TDRD5Tudor domain containing 5. (1035 aa)
SPIRE2Spire type actin nucleation factor 2. (702 aa)
TDRD1Tudor domain containing 1. (1153 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
MLH3MutL homolog 3. (1453 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
MASTLMicrotubule associated serine/threonine kinase like. (878 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (218 aa)
MMP19Matrix metallopeptidase 19. (491 aa)
KMT2DLysine methyltransferase 2D. (5292 aa)
TUT4Terminal uridylyl transferase 4. (1628 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
ASPMAbnormal spindle microtubule assembly. (3388 aa)
ZNF830Zinc finger protein 830. (388 aa)
TRIM75PTripartite motif containing 75, pseudogene. (468 aa)
LOC10058595440S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (239 aa)
PAQR6Uncharacterized protein. (363 aa)
MEIKINMeiotic kinetochore factor. (369 aa)
PTNPleiotrophin. (172 aa)
MTHFSDMethenyltetrahydrofolate synthetase domain containing. (383 aa)
NRIP1Nuclear receptor interacting protein 1. (1158 aa)
ENSNLEP0000002748540S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (223 aa)
LOC100593129Rhodanese domain-containing protein. (501 aa)
IMMP2LMitochondrial inner membrane protease subunit. (175 aa)
M1APMeiosis 1 associated protein. (530 aa)
ENSNLEP00000029497PLD phosphodiesterase domain-containing protein. (233 aa)
ENSNLEP00000029686Uncharacterized protein. (112 aa)
AURKCAurora kinase C; Belongs to the protein kinase superfamily. (309 aa)
SEPTIN1Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (70 aa)
MEI4Meiotic double-stranded break formation protein 4. (384 aa)
ZGLP1Zinc finger GATA like protein 1. (270 aa)
PTX3Pentraxin 3. (381 aa)
TDRD6Tudor domain containing 6. (2094 aa)
PDE3APhosphodiesterase. (1141 aa)
MLH1MutL homolog 1. (756 aa)
CCDC155Coiled-coil domain containing 155. (564 aa)
TUT7Terminal uridylyl transferase 7. (1493 aa)
MEIOCMeiosis specific with coiled-coil domain. (932 aa)
HROBChromosome 17 open reading frame 53. (641 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CTNNB1Catenin beta 1. (781 aa)
FOSL1BZIP domain-containing protein. (271 aa)
BCL2L10BCL2 like 10. (231 aa)
TAF4BTATA-box binding protein associated factor 4b. (867 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
CCDC36Coiled-coil domain containing 36. (595 aa)
NDC80NDC80 kinetochore complex component. (642 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (403 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (389 aa)
PGRUncharacterized protein. (339 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3055 aa)
AFPAlpha fetoprotein. (605 aa)
EREGEpiregulin. (169 aa)
YBX2CSD_1 domain-containing protein. (299 aa)
BMP15Bone morphogenetic protein 15. (392 aa)
ZP3ZP domain-containing protein. (349 aa)
RAD51CRAD51 paralog C. (370 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (373 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
G1RC35_NOMLEUncharacterized protein. (252 aa)
SPIRE1Spire type actin nucleation factor 1. (623 aa)
IHHIndian hedgehog signaling molecule. (389 aa)
PDE5APhosphodiesterase. (875 aa)
YTHDC1YTH domain containing 1. (725 aa)
MSH4MutS homolog 4. (933 aa)
SYCP2Synaptonemal complex protein 2. (1527 aa)
HORMAD1HORMA domain containing 1. (394 aa)
FIGLAFolliculogenesis specific bHLH transcription factor. (218 aa)
TDRKHTudor and KH domain containing. (596 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1067 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
TRIP13Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (432 aa)
TDRD10Tudor domain containing 10. (322 aa)
RPS6KA2Non-specific serine/threonine protein kinase. (692 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
IL4RInterleukin 4 receptor. (810 aa)
LOC100580067BHLH domain-containing protein. (425 aa)
YTHDC2YTH domain containing 2. (1430 aa)
AMHTGF_BETA_2 domain-containing protein. (341 aa)
TDRD15Uncharacterized protein. (1608 aa)
PAQR8Progestin and adipoQ receptor family member 8. (354 aa)
DDX20DEAD-box helicase 20. (824 aa)
ENSNLEP00000038023Uncharacterized protein; Belongs to the cyclin family. (352 aa)
HEXBBeta-hexosaminidase. (546 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (588 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CDC25BRhodanese domain-containing protein. (485 aa)
WDR77WD repeat domain 77. (347 aa)
ENSNLEP00000035372TGF_BETA_2 domain-containing protein. (392 aa)
MARF1Meiosis regulator and mRNA stability factor 1. (1731 aa)
NPM2Nucleophosmin/nucleoplasmin 2. (215 aa)
ENSNLEP0000003317140S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (244 aa)
PAQR5Progestin and adipoQ receptor family member 5. (332 aa)
ENSNLEP00000047907Uncharacterized protein. (152 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (595 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1122 aa)
ENSNLEP00000046801Protein kinase domain-containing protein. (214 aa)
PRDM9Uncharacterized protein. (678 aa)
NANOS3Nanos C2HC-type zinc finger 3; Belongs to the nanos family. (193 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
FBXO5F-box protein 5. (428 aa)
HSF2BPHeat shock transcription factor 2 binding protein. (334 aa)
ENSNLEP00000043395Uncharacterized protein. (197 aa)
ENSNLEP00000043394CSD domain-containing protein. (172 aa)
PABPC1LPABC domain-containing protein. (171 aa)
GAS2Growth arrest specific 2. (314 aa)
ENSNLEP00000042687Uncharacterized protein. (245 aa)
LOC10060076540S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (250 aa)
NCAPHCondensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (745 aa)
LOC100587270MCM domain-containing protein. (700 aa)
EDN1Endothelin 1. (211 aa)
NCAPH2Non-SMC condensin II complex subunit H2. (594 aa)
DIAPH2Diaphanous related formin 2. (1102 aa)
BRCA2BRCA2 DNA repair associated. (3419 aa)
MMP2Matrix metallopeptidase 2. (647 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1502 aa)
ERCC1Uncharacterized protein. (190 aa)
SEBOXSEBOX homeobox. (189 aa)
BHMG1Basic helix-loop-helix and HMG-box containing 1. (638 aa)
WEE2Wee1-like protein kinase. (552 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
NOBOXNOBOX oogenesis homeobox. (687 aa)
FMN2Formin 2. (1613 aa)
GPR149G protein-coupled receptor 149. (731 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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