STRINGSTRING
ZBTB18 ZBTB18 EOMES EOMES CDK5 CDK5 KLHL41 KLHL41 POPDC2 POPDC2 MYF5 MYF5 KRAS KRAS MYH14 MYH14 CHRNA1 CHRNA1 HOXD10 HOXD10 HOXD9 HOXD9 COPS2 COPS2 RHOA RHOA MYOM1 MYOM1 FLNB FLNB BCL9L BCL9L CDON CDON BARX2 BARX2 HLF HLF PITX1 PITX1 NOTCH1 NOTCH1 G1RAR4_NOMLE G1RAR4_NOMLE SOX8 SOX8 FOXN2 FOXN2 R3HDM1 R3HDM1 EGR1 EGR1 MYOZ2 MYOZ2 MYLK2 MYLK2 G1RHS2_NOMLE G1RHS2_NOMLE MSC MSC NPHS1 NPHS1 CAV2 CAV2 ANKRD33B ANKRD33B CNTNAP1 CNTNAP1 HEYL HEYL MEGF10 MEGF10 HIVEP3 HIVEP3 ANKRD1 ANKRD1 SMO SMO GTF3C5 GTF3C5 VGLL2 VGLL2 IGSF8 IGSF8 CASQ1 CASQ1 DNER DNER SIX1 SIX1 HLX HLX EMD EMD BVES BVES POPDC3 POPDC3 TAZ TAZ CHRND CHRND ACTA1 ACTA1 PMP22 PMP22 CITED2 CITED2 MAFF MAFF NEURL1 NEURL1 PEG10 PEG10 MEOX2 MEOX2 VAX1 VAX1 MYOZ1 MYOZ1 ASB2 ASB2 P2RX5 P2RX5 STAC3 STAC3 ITGA7 ITGA7 NR4A1 NR4A1 ANKRD33 ANKRD33 CSRP3 CSRP3 CACNA1S CACNA1S MYOG MYOG RTL5 RTL5 RTL1 RTL1 MAPK14 MAPK14 ENSNLEP00000024738 ENSNLEP00000024738 SVIL SVIL BTG2 BTG2 ENSNLEP00000024959 ENSNLEP00000024959 MYF6 MYF6 MED20 MED20 WNT3A WNT3A PPP3CB PPP3CB MYLPF MYLPF FOS FOS NR2F2 NR2F2 PAX5 PAX5 WNT10B WNT10B EGR2 EGR2 PLEC PLEC MYL6 MYL6 BIN3 BIN3 BCL9 BCL9 NF1 NF1 R3HDM2 R3HDM2 GPCPD1 GPCPD1 RYR1 RYR1 MEF2D MEF2D ENSNLEP00000036861 ENSNLEP00000036861 ENSNLEP00000036737 ENSNLEP00000036737 BCL2 BCL2 EP300 EP300 HOMER1 HOMER1 SAP30 SAP30 MEF2C MEF2C DMD DMD ENSNLEP00000033778 ENSNLEP00000033778 SPG11 SPG11 TCF21 TCF21 CAV1 CAV1 ENSNLEP00000031796 ENSNLEP00000031796 PPP3CA PPP3CA ENSNLEP00000031566 ENSNLEP00000031566 CCNT2 CCNT2 PHOX2B PHOX2B VRK3 VRK3 DLL1 DLL1 ZNF689 ZNF689 COL19A1 COL19A1 NUPR1 NUPR1 LMOD3 LMOD3 RIPOR2 RIPOR2 ATF3 ATF3 SMYD1 SMYD1 KEL KEL RB1 RB1 CFL2 CFL2 MYH15 MYH15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZBTB18Zinc finger and BTB domain containing 18. (524 aa)
EOMESEomesodermin. (705 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
KLHL41Kelch like family member 41. (606 aa)
POPDC2Popeye domain containing 2. (364 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1999 aa)
CHRNA1Cholinergic receptor nicotinic alpha 1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (444 aa)
HOXD10Homeobox D10. (340 aa)
HOXD9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (310 aa)
COPS2COP9 signalosome subunit 2. (450 aa)
RHOARas homolog family member A. (193 aa)
MYOM1Myomesin 1. (1685 aa)
FLNBFilamin B. (2585 aa)
BCL9LBCL9 like. (1338 aa)
CDONCell adhesion associated, oncogene regulated. (1171 aa)
BARX2Homeobox domain-containing protein. (311 aa)
HLFHLF transcription factor, PAR bZIP family member. (295 aa)
PITX1Homeobox protein. (296 aa)
NOTCH1Notch receptor 1. (2451 aa)
G1RAR4_NOMLEUncharacterized protein. (174 aa)
SOX8SRY-box transcription factor 8. (446 aa)
FOXN2Forkhead box N2. (431 aa)
R3HDM1R3H domain containing 1. (1100 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
MYOZ2Myozenin 2. (264 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
G1RHS2_NOMLEHP domain-containing protein. (80 aa)
MSCBHLH domain-containing protein. (297 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1192 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (86 aa)
ANKRD33BAnkyrin repeat domain 33B. (492 aa)
CNTNAP1Contactin associated protein 1. (1384 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (279 aa)
MEGF10Multiple EGF like domains 10. (1140 aa)
HIVEP3Human immunodeficiency virus type I enhancer binding protein 3. (2334 aa)
ANKRD1Ankyrin repeat domain 1. (286 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (683 aa)
GTF3C5General transcription factor IIIC subunit 5. (516 aa)
VGLL2Vestigial like family member 2. (317 aa)
IGSF8Immunoglobulin superfamily member 8. (611 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (121 aa)
DNERDelta/notch like EGF repeat containing. (661 aa)
SIX1SIX homeobox 1. (284 aa)
HLXH2.0 like homeobox. (441 aa)
EMDEmerin. (254 aa)
BVESBlood vessel epicardial substance. (360 aa)
POPDC3Popeye domain containing 3. (291 aa)
TAZTafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (239 aa)
CHRNDCholinergic receptor nicotinic delta subunit. (502 aa)
ACTA1Actin alpha 1, skeletal muscle. (370 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
MAFFMAF bZIP transcription factor F. (170 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
PEG10CCHC-type domain-containing protein. (775 aa)
MEOX2Mesenchyme homeobox 2. (303 aa)
VAX1Ventral anterior homeobox 1. (334 aa)
MYOZ1Myozenin 1. (299 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (635 aa)
P2RX5P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (422 aa)
STAC3SH3 and cysteine rich domain 3. (364 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1023 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (589 aa)
ANKRD33Ankyrin repeat domain 33. (449 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1679 aa)
MYOGMyogenin. (249 aa)
RTL5Retrotransposon Gag like 5. (569 aa)
RTL1Retrotransposon Gag like 1. (1359 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
ENSNLEP00000024738DMA domain-containing protein. (449 aa)
SVILSupervillin. (1949 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
ENSNLEP00000024959Uncharacterized protein. (131 aa)
MYF6Myogenic factor 6. (235 aa)
MED20Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (212 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PPP3CBSerine/threonine-protein phosphatase. (408 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (199 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (414 aa)
PAX5Paired box 5. (391 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
EGR2Early growth response 2. (476 aa)
PLECPlectin. (4280 aa)
MYL6Uncharacterized protein. (236 aa)
BIN3Bridging integrator 3. (253 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
NF1Neurofibromin 1. (2839 aa)
R3HDM2R3H domain containing 2. (1033 aa)
GPCPD1Glycerophosphocholine phosphodiesterase 1. (667 aa)
RYR1Ryanodine receptor 1. (4415 aa)
MEF2DMADS-box domain-containing protein. (139 aa)
ENSNLEP00000036861Uncharacterized protein. (119 aa)
ENSNLEP00000036737Uncharacterized protein. (160 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
EP300E1A binding protein p300. (2306 aa)
HOMER1Homer scaffold protein 1. (377 aa)
SAP30Sin3A associated protein 30. (220 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
DMDDystrophin. (3685 aa)
ENSNLEP00000033778Uncharacterized protein. (143 aa)
SPG11SPG11 vesicle trafficking associated, spatacsin. (2443 aa)
TCF21Transcription factor 21. (179 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ENSNLEP00000031796Protein kinase domain-containing protein. (467 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ENSNLEP00000031566HP domain-containing protein. (71 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (730 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
VRK3VRK serine/threonine kinase 3. (474 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (737 aa)
ZNF689Zinc finger protein 689. (500 aa)
COL19A1Collagen type XIX alpha 1 chain. (1142 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (100 aa)
LMOD3Leiomodin 3. (559 aa)
RIPOR2RHO family interacting cell polarization regulator 2. (1068 aa)
ATF3Activating transcription factor 3. (181 aa)
SMYD1SET and MYND domain containing 1. (473 aa)
KELKell metallo-endopeptidase (Kell blood group). (720 aa)
RB1RB transcriptional corepressor 1. (919 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
MYH15Myosin heavy chain 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1946 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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