STRINGSTRING
LAMB1 LAMB1 VMP1 VMP1 HMX3 HMX3 IL1B IL1B EMP2 EMP2 ENSNLEP00000041273 ENSNLEP00000041273 TEAD4 TEAD4 FBLN1 FBLN1 IGFBP7 IGFBP7 LOC100580006 LOC100580006 PRLR PRLR ENSNLEP00000035822 ENSNLEP00000035822 TRO TRO ITGB3 ITGB3 TRIM28 TRIM28 ENSNLEP00000028388 ENSNLEP00000028388 PPARD PPARD PTGS2 PTGS2 ACOD1 ACOD1 STC1 STC1 A1CF A1CF EPO EPO UBE2Q1 UBE2Q1 PRDM14 PRDM14 SPP1 SPP1 FUT7 FUT7 MST1 MST1 MMP9 MMP9 DDR1 DDR1 TPPP3 TPPP3 TGFBR2 TGFBR2 RECK RECK SOD1 SOD1 LIF LIF SCGB1A1 SCGB1A1 FKBP4 FKBP4 PCSK5 PCSK5 ITGB4 ITGB4 CALCA CALCA MMP2 MMP2 BSG BSG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LAMB1Laminin subunit beta 1. (1810 aa)
VMP1Uncharacterized protein. (406 aa)
HMX3H6 family homeobox 3. (357 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
ENSNLEP00000041273Uncharacterized protein. (190 aa)
TEAD4TEA domain transcription factor 4. (420 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (716 aa)
IGFBP7Insulin like growth factor binding protein 7. (284 aa)
LOC100580006Uncharacterized protein. (371 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (622 aa)
ENSNLEP0000003582260S ribosomal protein L29; Belongs to the eukaryotic ribosomal protein eL29 family. (148 aa)
TROTrophinin. (1411 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
TRIM28Tripartite motif containing 28. (808 aa)
ENSNLEP00000028388Uncharacterized protein. (141 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
ACOD1Aconitate decarboxylase 1. (489 aa)
STC1Stanniocalcin 1. (247 aa)
A1CFAPOBEC1 complementation factor. (595 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
UBE2Q1Ubiquitin conjugating enzyme E2 Q1. (422 aa)
PRDM14PR/SET domain 14. (496 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
FUT7Fucosyltransferase 7. (342 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
MMP9Matrix metallopeptidase 9. (692 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (913 aa)
TPPP3Tubulin polymerization promoting protein family member 3. (176 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (971 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
SCGB1A1Secretoglobin family 1A member 1. (91 aa)
FKBP4Peptidylprolyl isomerase. (424 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1860 aa)
ITGB4Integrin beta. (1746 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
MMP2Matrix metallopeptidase 2. (647 aa)
BSGUncharacterized protein. (345 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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