STRINGSTRING
EFEMP1 EFEMP1 SPEM1 SPEM1 IL2 IL2 FGF11 FGF11 INHA INHA FGF1 FGF1 BMP10 BMP10 TGFA TGFA GDF5 GDF5 FGF19 FGF19 FGF3 FGF3 IL11 IL11 OSGIN1 OSGIN1 HDGFL3 HDGFL3 RABEP2 RABEP2 BMP6 BMP6 DKK1 DKK1 BMP8B BMP8B CDNF CDNF FAM71F2 FAM71F2 FAM71F1 FAM71F1 IL3 IL3 CSF2 CSF2 FGF2 FGF2 ENSNLEP00000036501 ENSNLEP00000036501 HDGF HDGF RABEP1 RABEP1 ENSNLEP00000035372 ENSNLEP00000035372 LOC100582356 LOC100582356 VEGFA VEGFA PGF PGF ENSNLEP00000030727 ENSNLEP00000030727 FGF12 FGF12 IGF2 IGF2 GDF15 GDF15 NENF NENF NGF NGF CSF3 CSF3 FGF10 FGF10 MACC1 MACC1 GDNF GDNF ENSNLEP00000027380 ENSNLEP00000027380 PTN PTN FGF20 FGF20 NTF4 NTF4 VEGFB VEGFB FGF21 FGF21 IL12A IL12A LOC100580921 LOC100580921 LOC100579700 LOC100579700 PROK1 PROK1 GDF6 GDF6 OSM OSM LIF LIF CSF1 CSF1 TIMP1 TIMP1 NTF3 NTF3 BMP5 BMP5 INHBA INHBA FGF6 FGF6 FGF23 FGF23 GDF7 GDF7 CCN3 CCN3 GRN GRN GDF3 GDF3 KITLG KITLG GDF1 GDF1 TDGF1 TDGF1 FGF7 FGF7 CSPG5 CSPG5 CLCF1 CLCF1 OSGIN2 OSGIN2 CD320 CD320 FGF16 FGF16 FGF22 FGF22 G1QHL5_NOMLE G1QHL5_NOMLE CNTF CNTF NRTN NRTN LOC100585742 LOC100585742 PDGFD PDGFD HGF HGF ENDOU ENDOU BDNF BDNF GDF11 GDF11 INHBC INHBC INHBE INHBE VEGFC VEGFC TGFB3 TGFB3 FGF13 FGF13 NRG4 NRG4 IGF1 IGF1 CLEC11A CLEC11A GMFB GMFB NRG1 NRG1 EGF EGF BMP1 BMP1 ENSNLEP00000038711 ENSNLEP00000038711 AMH AMH CXCL12 CXCL12 LACRT LACRT FGF17 FGF17 PDGFC PDGFC AREG AREG ENSNLEP00000041179 ENSNLEP00000041179 OGN OGN JAG2 JAG2 BMP4 BMP4 IL5 IL5 IL4 IL4 GDF9 GDF9 THBS4 THBS4 FGF9 FGF9 TGFB1 TGFB1 IL34 IL34 NODAL NODAL FBRS FBRS LEFTY1 LEFTY1 ENSNLEP00000046694 ENSNLEP00000046694 IL6 IL6 EPGN EPGN GDF10 GDF10 GDF2 GDF2 LOC100580921-2 LOC100580921-2 PDGFB PDGFB ANGPTL3 ANGPTL3 FGF8 FGF8 TFF1 TFF1 CCN2 CCN2 JAG1 JAG1 GMFG GMFG TGFB2 TGFB2 THPO THPO MSTN MSTN G1R5V1_NOMLE G1R5V1_NOMLE BMP7 BMP7 AMBN AMBN FGF14 FGF14 PPBP PPBP EREG EREG BTC BTC BMP15 BMP15 PDGFA PDGFA IL9 IL9 FGF5 FGF5 BMP3 BMP3 GFER GFER NRG2 NRG2 HBEGF HBEGF LOC100598046 LOC100598046 NRG3 NRG3 BMP2 BMP2 MIA MIA IL7 IL7 VEGFD VEGFD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EFEMP1EGF containing fibulin extracellular matrix protein 1. (493 aa)
SPEM1Spermatid maturation 1. (309 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
TGFATransforming growth factor alpha. (166 aa)
GDF5Growth differentiation factor 5. (442 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
IL11Uncharacterized protein. (170 aa)
OSGIN1Uncharacterized protein. (140 aa)
HDGFL3HDGF like 3. (203 aa)
RABEP2Uncharacterized protein. (417 aa)
BMP6TGF_BETA_2 domain-containing protein. (125 aa)
DKK1Dickkopf-like protein 1. (266 aa)
BMP8BTGF_BETA_2 domain-containing protein. (403 aa)
CDNFCerebral dopamine neurotrophic factor. (187 aa)
FAM71F2Uncharacterized protein. (161 aa)
FAM71F1DUF3699 domain-containing protein. (462 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (152 aa)
CSF2Colony stimulating factor 2. (144 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
ENSNLEP00000036501Uncharacterized protein. (326 aa)
HDGFHeparin binding growth factor. (251 aa)
RABEP1Rabaptin, RAB GTPase binding effector protein 1. (874 aa)
ENSNLEP00000035372TGF_BETA_2 domain-containing protein. (392 aa)
LOC100582356Uncharacterized protein. (217 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (393 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (225 aa)
ENSNLEP00000030727Uncharacterized protein. (198 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
IGF2IlGF domain-containing protein. (180 aa)
GDF15Growth differentiation factor 15. (308 aa)
NENFNeudesin neurotrophic factor; Belongs to the cytochrome b5 family. (168 aa)
NGFNGF domain-containing protein; Belongs to the NGF-beta family. (123 aa)
CSF3Colony stimulating factor 3. (207 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MACC1MET transcriptional regulator MACC1. (853 aa)
GDNFTGF_BETA_2 domain-containing protein. (169 aa)
ENSNLEP00000027380Uncharacterized protein. (448 aa)
PTNPleiotrophin. (172 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (203 aa)
LOC100580921Uncharacterized protein. (216 aa)
LOC100579700Uncharacterized protein. (219 aa)
PROK1Prokineticin 1. (105 aa)
GDF6Growth differentiation factor 6. (455 aa)
OSMOncostatin M. (252 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
TIMP1NTR domain-containing protein. (166 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (268 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
INHBAInhibin subunit beta A. (426 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
GDF7Growth differentiation factor 7. (450 aa)
CCN3Cellular communication network factor 3. (357 aa)
GRNGranulin precursor. (593 aa)
GDF3Growth differentiation factor 3. (364 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
GDF1TGF_BETA_2 domain-containing protein. (374 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CSPG5Uncharacterized protein. (321 aa)
CLCF1Uncharacterized protein. (322 aa)
OSGIN2Uncharacterized protein. (549 aa)
CD320CD320 molecule. (282 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
G1QHL5_NOMLEUncharacterized protein; Belongs to the heparin-binding growth factors family. (182 aa)
CNTFCiliary neurotrophic factor. (200 aa)
NRTNNeurturin. (197 aa)
LOC100585742Uncharacterized protein. (222 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
ENDOUEndonuclease, poly(U) specific. (411 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
GDF11TGF_BETA_2 domain-containing protein. (377 aa)
INHBCInhibin subunit beta C. (352 aa)
INHBEInhibin subunit beta E. (350 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
NRG4Neuregulin 4. (117 aa)
IGF1IlGF domain-containing protein. (196 aa)
CLEC11AUncharacterized protein. (312 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (150 aa)
NRG1Neuregulin 1. (713 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
BMP1Metalloendopeptidase. (981 aa)
ENSNLEP00000038711CFC domain-containing protein. (158 aa)
AMHTGF_BETA_2 domain-containing protein. (341 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
LACRTUncharacterized protein. (102 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
AREGEGF-like domain-containing protein. (274 aa)
ENSNLEP00000041179Spem1 domain-containing protein. (269 aa)
OGNOsteoglycin. (298 aa)
JAG2Jagged canonical Notch ligand 2. (1238 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (135 aa)
GDF9Growth differentiation factor 9. (455 aa)
THBS4Thrombospondin 4. (925 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL34Interleukin 34. (242 aa)
NODALNodal growth differentiation factor. (347 aa)
FBRSFibrosin. (980 aa)
LEFTY1Left-right determination factor. (365 aa)
ENSNLEP00000046694Uncharacterized protein. (461 aa)
IL6Uncharacterized protein. (258 aa)
EPGNEpithelial mitogen. (154 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
GDF2Growth differentiation factor 2. (429 aa)
LOC100580921-2Growth hormone B1. (217 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
ANGPTL3Angiopoietin like 3. (459 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
TFF1Trefoil factor 1. (84 aa)
CCN2Cellular communication network factor 2. (349 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1157 aa)
GMFGGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (142 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
THPOThrombopoietin. (353 aa)
MSTNMyostatin. (376 aa)
G1R5V1_NOMLEUncharacterized protein. (148 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
AMBNAmeloblastin. (447 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
PPBPC-X-C motif chemokine. (128 aa)
EREGEpiregulin. (169 aa)
BTCBetacellulin. (178 aa)
BMP15Bone morphogenetic protein 15. (392 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
IL9Interleukin 9. (144 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
GFERSulfhydryl oxidase. (205 aa)
NRG2Uncharacterized protein. (597 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
LOC100598046TGFb_propeptide domain-containing protein. (248 aa)
NRG3Neuregulin 3. (720 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
MIASH3 domain-containing protein. (131 aa)
IL7Interleukin 7. (179 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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