STRINGSTRING
NT5E NT5E IMPDH IMPDH LOC100581732 LOC100581732 AK9 AK9 GMPR2 GMPR2 NT5C1A NT5C1A PNP PNP CARD11 CARD11 NUDT2 NUDT2 ADA ADA ENSNLEP00000031521 ENSNLEP00000031521 ENSNLEP00000031212 ENSNLEP00000031212 AMPD1 AMPD1 DLG2 DLG2 ENSNLEP00000038989 ENSNLEP00000038989 ADSS2 ADSS2 LOC100585501 LOC100585501 MAGI3 MAGI3 DCK DCK IMPDH1 IMPDH1 PAICS PAICS XDH XDH ENSNLEP00000044316 ENSNLEP00000044316 GUK1 GUK1 AMPD3 AMPD3 AK4 AK4 DGUOK DGUOK ADSL ADSL ENSNLEP00000040993 ENSNLEP00000040993 PFAS PFAS AK3 AK3 PPAT PPAT ATIC ATIC IMPDH2 IMPDH2 GART GART GMPS GMPS AMPD2 AMPD2 AK4-2 AK4-2 ENSNLEP00000029534 ENSNLEP00000029534 CASK CASK HPRT1 HPRT1 ENSNLEP00000026588 ENSNLEP00000026588 NT5C2 NT5C2 ADK ADK GDA GDA DLG1 DLG1 AK2 AK2 ENSNLEP00000029241 ENSNLEP00000029241 NT5C NT5C ENSNLEP00000024528 ENSNLEP00000024528 AK1 AK1 ADSS1 ADSS1 APRT APRT NT5DC1 NT5DC1 LRGUK LRGUK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa)
IMPDHInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (516 aa)
LOC100581732Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (581 aa)
AK9Adenylate kinase 9. (1911 aa)
GMPR2GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (395 aa)
NT5C1A5'-nucleotidase, cytosolic IA. (328 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
NUDT2Nudix hydrolase 2. (147 aa)
ADAAdenosine deaminase. (405 aa)
ENSNLEP00000031521Uncharacterized protein. (491 aa)
ENSNLEP00000031212Uncharacterized protein. (300 aa)
AMPD1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (780 aa)
DLG2Discs large MAGUK scaffold protein 2. (975 aa)
ENSNLEP00000038989Uncharacterized protein. (64 aa)
ADSS2Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (458 aa)
LOC100585501IMPDH domain-containing protein. (529 aa)
MAGI3Membrane associated guanylate kinase, WW and PDZ domain containing 3. (1481 aa)
DCKdNK domain-containing protein. (317 aa)
IMPDH1CBS domain-containing protein. (487 aa)
PAICSAIRC domain-containing protein. (451 aa)
XDHXanthine dehydrogenase. (1271 aa)
ENSNLEP00000044316Uncharacterized protein; Belongs to the adenylate kinase family. (134 aa)
GUK1Guanylate kinase-like domain-containing protein. (272 aa)
AMPD3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (776 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
DGUOKDeoxyguanosine kinase. (277 aa)
ADSLAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (498 aa)
ENSNLEP00000040993Uncharacterized protein. (521 aa)
PFASUncharacterized protein. (1108 aa)
AK3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (223 aa)
PPATAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (545 aa)
ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (592 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
GARTTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
GMPSGuanine monophosphate synthase. (693 aa)
AMPD2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (879 aa)
AK4-2ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (209 aa)
ENSNLEP00000029534AIRC domain-containing protein. (373 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (912 aa)
HPRT1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
ENSNLEP00000026588GMP_synt_C domain-containing protein. (233 aa)
NT5C25'-nucleotidase, cytosolic II. (584 aa)
ADKAdenosine kinase. (362 aa)
GDAGuanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (471 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (916 aa)
AK2Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (239 aa)
ENSNLEP00000029241ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (190 aa)
NT5C5', 3'-nucleotidase, cytosolic. (201 aa)
ENSNLEP00000024528Uncharacterized protein. (493 aa)
AK1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (210 aa)
ADSS1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (457 aa)
APRTAdenine phosphoribosyltransferase. (180 aa)
NT5DC15'-nucleotidase domain containing 1. (411 aa)
LRGUKLeucine rich repeats and guanylate kinase domain containing. (826 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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