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NUDT2 NUDT2 DGUOK DGUOK AMPD3 AMPD3 ADSL ADSL ENSNLEP00000040993 ENSNLEP00000040993 LOC100581732 LOC100581732 IMPDH IMPDH ENSNLEP00000038989 ENSNLEP00000038989 ADSS2 ADSS2 LOC100585501 LOC100585501 DCK DCK IMPDH1 IMPDH1 PAICS PAICS ADA ADA ENSNLEP00000031521 ENSNLEP00000031521 AMPD1 AMPD1 ENSNLEP00000029534 ENSNLEP00000029534 ADK ADK ENSNLEP00000026588 ENSNLEP00000026588 ENSNLEP00000024528 ENSNLEP00000024528 ADSS1 ADSS1 APRT APRT PFAS PFAS PPAT PPAT ATIC ATIC IMPDH2 IMPDH2 GART GART GMPS GMPS AMPD2 AMPD2 HPRT1 HPRT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NUDT2Nudix hydrolase 2. (147 aa)
DGUOKDeoxyguanosine kinase. (277 aa)
AMPD3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (776 aa)
ADSLAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (498 aa)
ENSNLEP00000040993Uncharacterized protein. (521 aa)
LOC100581732Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (581 aa)
IMPDHInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (516 aa)
ENSNLEP00000038989Uncharacterized protein. (64 aa)
ADSS2Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (458 aa)
LOC100585501IMPDH domain-containing protein. (529 aa)
DCKdNK domain-containing protein. (317 aa)
IMPDH1CBS domain-containing protein. (487 aa)
PAICSAIRC domain-containing protein. (451 aa)
ADAAdenosine deaminase. (405 aa)
ENSNLEP00000031521Uncharacterized protein. (491 aa)
AMPD1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (780 aa)
ENSNLEP00000029534AIRC domain-containing protein. (373 aa)
ADKAdenosine kinase. (362 aa)
ENSNLEP00000026588GMP_synt_C domain-containing protein. (233 aa)
ENSNLEP00000024528Uncharacterized protein. (493 aa)
ADSS1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (457 aa)
APRTAdenine phosphoribosyltransferase. (180 aa)
PFASUncharacterized protein. (1108 aa)
PPATAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (545 aa)
ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (592 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
GARTTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
GMPSGuanine monophosphate synthase. (693 aa)
AMPD2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (879 aa)
HPRT1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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