STRINGSTRING
ENSNLEP00000034659 ENSNLEP00000034659 PRKCA PRKCA APOH APOH G1QHL5_NOMLE G1QHL5_NOMLE BSG BSG HMGB1 HMGB1 EDN1 EDN1 FGF16 FGF16 STARD13 STARD13 SMOC2 SMOC2 RGCC RGCC ANXA1 ANXA1 ADGRB1 ADGRB1 AGT AGT SYNJ2BP SYNJ2BP TSTA3 TSTA3 FLT4 FLT4 MMRN2 MMRN2 PLK2 PLK2 TBXA2R TBXA2R PRKD2 PRKD2 DLL4 DLL4 NOS3 NOS3 PIK3CB PIK3CB PATZ1 PATZ1 MAP3K3 MAP3K3 PDCD10 PDCD10 RRAS RRAS GRN GRN EMC10 EMC10 FBXW7 FBXW7 TDGF1 TDGF1 PLCG1 PLCG1 HRG HRG RHOA RHOA PTPRM PTPRM WNT5A WNT5A ETS1 ETS1 SRPX2 SRPX2 EPHA2 EPHA2 CXCL13 CXCL13 NOTCH1 NOTCH1 ANXA3 ANXA3 CCBE1 CCBE1 DNAJA4 DNAJA4 PIK3CG PIK3CG GADD45A GADD45A ALOX12 ALOX12 PIK3CD PIK3CD ANGPT4 ANGPT4 LOC100592336 LOC100592336 FGF1 FGF1 RIN2 RIN2 BMP10 BMP10 CEACAM1 CEACAM1 JUP JUP ZC3H12A ZC3H12A SEMA5A SEMA5A ADAMTS9 ADAMTS9 GATA3 GATA3 CIB1 CIB1 SIRT1 SIRT1 ADGRA2 ADGRA2 FGFR1 FGFR1 SVBP SVBP SEMA4A SEMA4A ABL1 ABL1 BMP4 BMP4 CALR CALR MAP2K5 MAP2K5 ADAM17 ADAM17 NR2E1 NR2E1 TGFB1 TGFB1 SP100 SP100 RHOJ RHOJ GATA2 GATA2 PROX1 PROX1 AMOT AMOT CARD10 CARD10 ANGPT2 ANGPT2 PDGFB PDGFB SASH1 SASH1 GDF2 GDF2 BMPER BMPER PRKD1 PRKD1 RAC1 RAC1 STC1 STC1 PTK2B PTK2B TEK TEK MEOX2 MEOX2 SPARC SPARC EGF EGF VASH1 VASH1 HDAC9 HDAC9 VEGFC VEGFC JCAD JCAD SP1 SP1 ACVRL1 ACVRL1 GLUL GLUL PTGS2 PTGS2 ATP2B4 ATP2B4 G1SAU3_NOMLE G1SAU3_NOMLE AKT3 AKT3 M3ZBW0_NOMLE M3ZBW0_NOMLE MET MET NRP1 NRP1 SERPINF1 SERPINF1 KRIT1 KRIT1 ATP5F1B ATP5F1B FBXW9 FBXW9 EFNA1 EFNA1 PTN PTN ENSNLEP00000027457 ENSNLEP00000027457 ENSNLEP00000027702 ENSNLEP00000027702 SPRED1 SPRED1 ENSNLEP00000027935 ENSNLEP00000027935 AKT1 AKT1 ENSNLEP00000028612 ENSNLEP00000028612 KLF4 KLF4 ENSNLEP00000032011 ENSNLEP00000032011 ITGB3 ITGB3 CD40 CD40 VEGFA VEGFA MEF2C MEF2C PTK2 PTK2 NUS1 NUS1 ENSNLEP00000034859 ENSNLEP00000034859 FOXP1 FOXP1 AGTR2 AGTR2 ROCK2 ROCK2 MECP2 MECP2 ENSNLEP00000036737 ENSNLEP00000036737 BCAS3 BCAS3 ENSNLEP00000036881 ENSNLEP00000036881 AAMP AAMP PPARG PPARG FGF2 FGF2 HDAC7 HDAC7 ENSNLEP00000037750 ENSNLEP00000037750 ENSNLEP00000037799 ENSNLEP00000037799 ENSNLEP00000038711 ENSNLEP00000038711 LGMN LGMN ENSNLEP00000039670 ENSNLEP00000039670 NF1 NF1 LOC100593010 LOC100593010 PLPP3 PLPP3 ANGPT1 ANGPT1 RHOB RHOB ENSNLEP00000041273 ENSNLEP00000041273 BCAR1 BCAR1 BMPR2 BMPR2 MAP2K3 MAP2K3 EMP2 EMP2 ENSNLEP00000042609 ENSNLEP00000042609 NFE2L2 NFE2L2 ATP5F1A ATP5F1A NRP2 NRP2 SCARB1 SCARB1 P2RX4 P2RX4 THBS1 THBS1 KDR KDR DAB2IP DAB2IP HMOX1 HMOX1 GPLD1 GPLD1 NR2F2 NR2F2 ITGB1BP1 ITGB1BP1 DCN DCN TNF TNF GPI GPI SLIT2 SLIT2 HIF1A HIF1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSNLEP00000034659Uncharacterized protein. (407 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
APOHApolipoprotein H. (345 aa)
G1QHL5_NOMLEUncharacterized protein; Belongs to the heparin-binding growth factors family. (182 aa)
BSGUncharacterized protein. (345 aa)
HMGB1High mobility group box 1. (215 aa)
EDN1Endothelin 1. (211 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
STARD13StAR related lipid transfer domain containing 13. (930 aa)
SMOC2SPARC related modular calcium binding 2. (423 aa)
RGCCRegulator of cell cycle. (137 aa)
ANXA1Annexin. (346 aa)
ADGRB1Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1489 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
TSTA3Tissue specific transplantation antigen P35B. (320 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
MMRN2Multimerin 2. (949 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
PRKD2Uncharacterized protein. (716 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (692 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
PATZ1Uncharacterized protein. (452 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (628 aa)
PDCD10Programmed cell death 10. (212 aa)
RRASRAS related. (217 aa)
GRNGranulin precursor. (593 aa)
EMC10Uncharacterized protein. (347 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
HRGHistidine rich glycoprotein. (530 aa)
RHOARas homolog family member A. (193 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1465 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
SRPX2Sushi repeat containing protein X-linked 2. (425 aa)
EPHA2EPH receptor A2. (976 aa)
CXCL13C-X-C motif chemokine ligand 13. (109 aa)
NOTCH1Notch receptor 1. (2451 aa)
ANXA3Annexin. (323 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
DNAJA4DnaJ heat shock protein family (Hsp40) member A4. (426 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (639 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1077 aa)
ANGPT4Angiopoietin 4. (480 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
RIN2Ras and Rab interactor 2. (930 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
CEACAM1Uncharacterized protein. (493 aa)
JUPJunction plakoglobin. (730 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (560 aa)
SEMA5ASemaphorin 5A. (1074 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1935 aa)
GATA3GATA binding protein 3. (444 aa)
CIB1Uncharacterized protein. (187 aa)
SIRT1Sirtuin 1. (734 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1128 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
SVBPSmall vasohibin binding protein. (66 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (758 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CALRCalreticulin. (417 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (414 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (422 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SP100SP100 nuclear antigen. (885 aa)
RHOJRas homolog family member J. (215 aa)
GATA2GATA binding protein 2. (480 aa)
PROX1Prospero homeobox 1. (737 aa)
AMOTAngiomotin. (1088 aa)
CARD10Caspase recruitment domain family member 10. (898 aa)
ANGPT2Angiopoietin 2. (496 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
SASH1SAM and SH3 domain containing 1. (1247 aa)
GDF2Growth differentiation factor 2. (429 aa)
BMPERBMP binding endothelial regulator. (685 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
RAC1Rac family small GTPase 1. (187 aa)
STC1Stanniocalcin 1. (247 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
MEOX2Mesenchyme homeobox 2. (303 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
VASH1Vasohibin 1. (364 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
JCADJunctional cadherin 5 associated. (1354 aa)
SP1Sp1 transcription factor. (786 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
GLULGlutamine synthetase. (373 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1241 aa)
G1SAU3_NOMLEL-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (338 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
M3ZBW0_NOMLESH2 domain-containing protein. (230 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (366 aa)
KRIT1Uncharacterized protein. (736 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (509 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (204 aa)
PTNPleiotrophin. (172 aa)
ENSNLEP00000027457Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (329 aa)
ENSNLEP00000027702Uncharacterized protein. (381 aa)
SPRED1Sprouty related EVH1 domain containing 1. (444 aa)
ENSNLEP00000027935Uncharacterized protein. (181 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ENSNLEP00000028612Uncharacterized protein. (134 aa)
KLF4Uncharacterized protein. (145 aa)
ENSNLEP00000032011Uncharacterized protein. (147 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
CD40TNFR-Cys domain-containing protein. (219 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (393 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1099 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
ENSNLEP00000034859Uncharacterized protein. (246 aa)
FOXP1Forkhead box P1. (693 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
MECP2MBD domain-containing protein. (156 aa)
ENSNLEP00000036737Uncharacterized protein. (160 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (950 aa)
ENSNLEP00000036881Uncharacterized protein. (179 aa)
AAMPAngio associated migratory cell protein. (434 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1004 aa)
ENSNLEP00000037750Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (341 aa)
ENSNLEP00000037799C2H2-type domain-containing protein. (162 aa)
ENSNLEP00000038711CFC domain-containing protein. (158 aa)
LGMNLegumain. (414 aa)
ENSNLEP00000039670Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (334 aa)
NF1Neurofibromin 1. (2839 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
PLPP3acidPPc domain-containing protein. (289 aa)
ANGPT1Angiopoietin 1. (498 aa)
RHOBRas homolog family member B. (196 aa)
ENSNLEP00000041273Uncharacterized protein. (190 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (827 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (317 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
ENSNLEP00000042609Uncharacterized protein. (168 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (607 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (545 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (550 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
THBS1Thrombospondin 1. (1173 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
DAB2IPDAB2 interacting protein. (1159 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (840 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (414 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (398 aa)
SLIT2Slit guidance ligand 2. (1389 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (30%) [HD]