STRINGSTRING
SPARC SPARC EGF EGF HDAC9 HDAC9 VEGFC VEGFC JCAD JCAD SP1 SP1 PTGS2 PTGS2 G1SAU3_NOMLE G1SAU3_NOMLE AKT3 AKT3 M3ZBW0_NOMLE M3ZBW0_NOMLE MET MET NRP1 NRP1 ATP5F1B ATP5F1B ENSNLEP00000027702 ENSNLEP00000027702 ENSNLEP00000027935 ENSNLEP00000027935 AKT1 AKT1 ITGB3 ITGB3 CD40 CD40 VEGFA VEGFA ENSNLEP00000034659 ENSNLEP00000034659 NUS1 NUS1 ENSNLEP00000034859 ENSNLEP00000034859 FOXP1 FOXP1 ROCK2 ROCK2 BCAS3 BCAS3 AAMP AAMP FGF2 FGF2 HDAC7 HDAC7 ENSNLEP00000038711 ENSNLEP00000038711 LGMN LGMN LOC100593010 LOC100593010 PLPP3 PLPP3 ANGPT1 ANGPT1 RHOB RHOB BCAR1 BCAR1 BMPR2 BMPR2 MAP2K3 MAP2K3 ENSNLEP00000042609 ENSNLEP00000042609 NFE2L2 NFE2L2 ATP5F1A ATP5F1A NRP2 NRP2 SCARB1 SCARB1 P2RX4 P2RX4 THBS1 THBS1 KDR KDR HMOX1 HMOX1 GPLD1 GPLD1 ITGB1BP1 ITGB1BP1 HIF1A HIF1A GPI GPI PRKCA PRKCA G1QHL5_NOMLE G1QHL5_NOMLE BSG BSG EDN1 EDN1 FGF16 FGF16 SMOC2 SMOC2 ANXA1 ANXA1 AGT AGT TSTA3 TSTA3 FLT4 FLT4 PLK2 PLK2 PRKD2 PRKD2 NOS3 NOS3 PIK3CB PIK3CB MAP3K3 MAP3K3 RRAS RRAS GRN GRN EMC10 EMC10 TDGF1 TDGF1 PLCG1 PLCG1 WNT5A WNT5A ETS1 ETS1 SRPX2 SRPX2 ANXA3 ANXA3 CCBE1 CCBE1 PIK3CG PIK3CG ALOX12 ALOX12 PIK3CD PIK3CD ANGPT4 ANGPT4 LOC100592336 LOC100592336 FGF1 FGF1 RIN2 RIN2 ZC3H12A ZC3H12A SEMA5A SEMA5A GATA3 GATA3 CIB1 CIB1 SIRT1 SIRT1 ADGRA2 ADGRA2 FGFR1 FGFR1 ABL1 ABL1 BMP4 BMP4 CALR CALR ADAM17 ADAM17 TGFB1 TGFB1 RHOJ RHOJ GATA2 GATA2 PROX1 PROX1 AMOT AMOT PDGFB PDGFB SASH1 SASH1 PRKD1 PRKD1 RAC1 RAC1 PTK2B PTK2B TEK TEK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPARCSecreted protein acidic and cysteine rich. (303 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
JCADJunctional cadherin 5 associated. (1354 aa)
SP1Sp1 transcription factor. (786 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
G1SAU3_NOMLEL-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (338 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
M3ZBW0_NOMLESH2 domain-containing protein. (230 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (509 aa)
ENSNLEP00000027702Uncharacterized protein. (381 aa)
ENSNLEP00000027935Uncharacterized protein. (181 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
CD40TNFR-Cys domain-containing protein. (219 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (393 aa)
ENSNLEP00000034659Uncharacterized protein. (407 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
ENSNLEP00000034859Uncharacterized protein. (246 aa)
FOXP1Forkhead box P1. (693 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (950 aa)
AAMPAngio associated migratory cell protein. (434 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1004 aa)
ENSNLEP00000038711CFC domain-containing protein. (158 aa)
LGMNLegumain. (414 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
PLPP3acidPPc domain-containing protein. (289 aa)
ANGPT1Angiopoietin 1. (498 aa)
RHOBRas homolog family member B. (196 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (827 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (317 aa)
ENSNLEP00000042609Uncharacterized protein. (168 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (607 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (545 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (550 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
THBS1Thrombospondin 1. (1173 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (840 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (398 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
G1QHL5_NOMLEUncharacterized protein; Belongs to the heparin-binding growth factors family. (182 aa)
BSGUncharacterized protein. (345 aa)
EDN1Endothelin 1. (211 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SMOC2SPARC related modular calcium binding 2. (423 aa)
ANXA1Annexin. (346 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
TSTA3Tissue specific transplantation antigen P35B. (320 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
PRKD2Uncharacterized protein. (716 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (628 aa)
RRASRAS related. (217 aa)
GRNGranulin precursor. (593 aa)
EMC10Uncharacterized protein. (347 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
SRPX2Sushi repeat containing protein X-linked 2. (425 aa)
ANXA3Annexin. (323 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (639 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1077 aa)
ANGPT4Angiopoietin 4. (480 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
RIN2Ras and Rab interactor 2. (930 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (560 aa)
SEMA5ASemaphorin 5A. (1074 aa)
GATA3GATA binding protein 3. (444 aa)
CIB1Uncharacterized protein. (187 aa)
SIRT1Sirtuin 1. (734 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1128 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CALRCalreticulin. (417 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
RHOJRas homolog family member J. (215 aa)
GATA2GATA binding protein 2. (480 aa)
PROX1Prospero homeobox 1. (737 aa)
AMOTAngiomotin. (1088 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
SASH1SAM and SH3 domain containing 1. (1247 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
RAC1Rac family small GTPase 1. (187 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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