STRINGSTRING
FGF10 FGF10 AKT1 AKT1 ENSNLEP00000027935 ENSNLEP00000027935 ENSNLEP00000027702 ENSNLEP00000027702 ENSNLEP00000027513 ENSNLEP00000027513 SOX9 SOX9 TACR1 TACR1 ATP5F1B ATP5F1B CLASP1 CLASP1 NRP1 NRP1 MET MET HDAC6 HDAC6 M3ZBW0_NOMLE M3ZBW0_NOMLE AKT3 AKT3 G1SAU3_NOMLE G1SAU3_NOMLE CALR CALR ADAM17 ADAM17 TGFB1 TGFB1 RHOJ RHOJ TGFB2 TGFB2 GATA2 GATA2 PROX1 PROX1 AMOT AMOT JUN JUN PDGFB PDGFB SASH1 SASH1 PRKD1 PRKD1 RAC1 RAC1 PTK2B PTK2B TEK TEK SPARC SPARC EGF EGF HDAC9 HDAC9 VEGFC VEGFC PRKCE PRKCE JCAD JCAD EPB41L4B EPB41L4B SP1 SP1 PTGS2 PTGS2 SEMA5A SEMA5A PRKCA PRKCA G1QHL5_NOMLE G1QHL5_NOMLE DOCK1 DOCK1 BSG BSG EDN1 EDN1 EPB41L5 EPB41L5 FGF16 FGF16 SMOC2 SMOC2 ANXA1 ANXA1 CAPN7 CAPN7 TSTA3 TSTA3 FLT4 FLT4 PLK2 PLK2 PRKD2 PRKD2 IFNG IFNG GLIPR2 GLIPR2 NOS3 NOS3 TGFBR2 TGFBR2 PIK3CB PIK3CB MAP3K3 MAP3K3 IQSEC1 IQSEC1 ENPP2 ENPP2 HAS2 HAS2 RRAS RRAS GATA3 GATA3 CIB1 CIB1 SIRT1 SIRT1 ADGRA2 ADGRA2 RAB25 RAB25 FGFR1 FGFR1 ABL1 ABL1 BMP4 BMP4 AGT AGT GRN GRN EMC10 EMC10 TDGF1 TDGF1 FGF7 FGF7 MAPRE2 MAPRE2 PLCG1 PLCG1 MMP9 MMP9 HYAL1 HYAL1 WNT5A WNT5A ETS1 ETS1 SRPX2 SRPX2 ANXA3 ANXA3 CCBE1 CCBE1 VIL1 VIL1 CTSH CTSH PIK3CG PIK3CG ITGA3 ITGA3 HBEGF HBEGF ALOX12 ALOX12 PIK3CD PIK3CD ANGPT4 ANGPT4 LOC100592336 LOC100592336 FGF1 FGF1 RIN2 RIN2 PLCG2 PLCG2 ZC3H12A ZC3H12A HIF1A HIF1A SRC SRC GPI GPI ITGB1BP1 ITGB1BP1 CLASP2 CLASP2 PFN1-2 PFN1-2 IRS2 IRS2 GPLD1 GPLD1 HMOX1 HMOX1 KDR KDR THBS1 THBS1 P2RX4 P2RX4 PPM1F PPM1F SCARB1 SCARB1 NRP2 NRP2 ATP5F1A ATP5F1A NFE2L2 NFE2L2 ENSNLEP00000042675 ENSNLEP00000042675 ENSNLEP00000042609 ENSNLEP00000042609 ITGA2 ITGA2 CCR6 CCR6 MAP2K3 MAP2K3 BMPR2 BMPR2 BCAR1 BCAR1 RHOB RHOB ANGPT1 ANGPT1 PLPP3 PLPP3 LOC100593010 LOC100593010 MAP4K4 MAP4K4 LGMN LGMN ENSNLEP00000038711 ENSNLEP00000038711 RREB1 RREB1 HDAC7 HDAC7 FGF2 FGF2 AAMP AAMP BCAS3 BCAS3 ROCK2 ROCK2 FOXP1 FOXP1 ENSNLEP00000034859 ENSNLEP00000034859 NUS1 NUS1 ENSNLEP00000034659 ENSNLEP00000034659 VEGFA VEGFA MTOR MTOR ENSNLEP00000032709 ENSNLEP00000032709 CD40 CD40 ITGB3 ITGB3 ARF6 ARF6 ADAM9 ADAM9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ENSNLEP00000027935Uncharacterized protein. (181 aa)
ENSNLEP00000027702Uncharacterized protein. (381 aa)
ENSNLEP00000027513Uncharacterized protein. (154 aa)
SOX9SRY-box transcription factor 9. (510 aa)
TACR1Tachykinin receptor 1. (406 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (509 aa)
CLASP1Cytoplasmic linker associated protein 1. (1538 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
HDAC6Uncharacterized protein. (146 aa)
M3ZBW0_NOMLESH2 domain-containing protein. (230 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
G1SAU3_NOMLEL-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (338 aa)
CALRCalreticulin. (417 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
RHOJRas homolog family member J. (215 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GATA2GATA binding protein 2. (480 aa)
PROX1Prospero homeobox 1. (737 aa)
AMOTAngiomotin. (1088 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (305 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
SASH1SAM and SH3 domain containing 1. (1247 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
RAC1Rac family small GTPase 1. (187 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
JCADJunctional cadherin 5 associated. (1354 aa)
EPB41L4BErythrocyte membrane protein band 4.1 like 4B. (818 aa)
SP1Sp1 transcription factor. (786 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
SEMA5ASemaphorin 5A. (1074 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
G1QHL5_NOMLEUncharacterized protein; Belongs to the heparin-binding growth factors family. (182 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa)
BSGUncharacterized protein. (345 aa)
EDN1Endothelin 1. (211 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (732 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SMOC2SPARC related modular calcium binding 2. (423 aa)
ANXA1Annexin. (346 aa)
CAPN7Calpain 7; Belongs to the peptidase C2 family. (813 aa)
TSTA3Tissue specific transplantation antigen P35B. (320 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
PRKD2Uncharacterized protein. (716 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (181 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (628 aa)
IQSEC1IQ motif and Sec7 domain 1. (1098 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (893 aa)
HAS2Hyaluronan synthase 2. (552 aa)
RRASRAS related. (217 aa)
GATA3GATA binding protein 3. (444 aa)
CIB1Uncharacterized protein. (187 aa)
SIRT1Sirtuin 1. (734 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1128 aa)
RAB25RAB25, member RAS oncogene family. (213 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
GRNGranulin precursor. (593 aa)
EMC10Uncharacterized protein. (347 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
MAPRE2Microtubule associated protein RP/EB family member 2. (327 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
MMP9Matrix metallopeptidase 9. (692 aa)
HYAL1Hyaluronidase. (435 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
SRPX2Sushi repeat containing protein X-linked 2. (425 aa)
ANXA3Annexin. (323 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
VIL1Villin 1. (827 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1050 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (639 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1077 aa)
ANGPT4Angiopoietin 4. (480 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
RIN2Ras and Rab interactor 2. (930 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1218 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (560 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
SRCTyrosine-protein kinase. (537 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (398 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
CLASP2Uncharacterized protein. (1515 aa)
PFN1-2Profilin; Belongs to the profilin family. (128 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (840 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
THBS1Thrombospondin 1. (1173 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (454 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (550 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (545 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (607 aa)
ENSNLEP00000042675Uncharacterized protein. (89 aa)
ENSNLEP00000042609Uncharacterized protein. (168 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (377 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (317 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (827 aa)
RHOBRas homolog family member B. (196 aa)
ANGPT1Angiopoietin 1. (498 aa)
PLPP3acidPPc domain-containing protein. (289 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4. (1346 aa)
LGMNLegumain. (414 aa)
ENSNLEP00000038711CFC domain-containing protein. (158 aa)
RREB1Ras responsive element binding protein 1. (1719 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1004 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
AAMPAngio associated migratory cell protein. (434 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (950 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
FOXP1Forkhead box P1. (693 aa)
ENSNLEP00000034859Uncharacterized protein. (246 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
ENSNLEP00000034659Uncharacterized protein. (407 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (393 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
ENSNLEP00000032709Profilin; Belongs to the profilin family. (120 aa)
CD40TNFR-Cys domain-containing protein. (219 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
ARF6Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (175 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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