STRINGSTRING
SNAI1 SNAI1 DAG1 DAG1 SFRP2 SFRP2 CTNNB1 CTNNB1 ELL3 ELL3 ALX1 ALX1 FUZ FUZ PAWR PAWR USF3 USF3 TGFBR2 TGFBR2 GLIPR2 GLIPR2 NKX2-1 NKX2-1 TIAM1 TIAM1 BMP5 BMP5 TRIM62 TRIM62 WWTR1 WWTR1 SDHAF2 SDHAF2 TBX20 TBX20 RGCC RGCC ACVR1 ACVR1 TBX5 TBX5 LEF1 LEF1 FERMT2 FERMT2 HDAC2 HDAC2 SPRED2 SPRED2 FOXA1 FOXA1 TGFBR1 TGFBR1 ENSNLEP00000041273 ENSNLEP00000041273 PPP2CA PPP2CA SMAD3 SMAD3 FOXA2 FOXA2 MCRIP1 MCRIP1 EMP2 EMP2 ENSNLEP00000042367 ENSNLEP00000042367 EPHA4 EPHA4 NOG NOG DAB2IP DAB2IP IL1B IL1B ENSNLEP00000045603 ENSNLEP00000045603 POFUT2 POFUT2 ZNF703 ZNF703 SDCBP SDCBP ADIPOR1 ADIPOR1 CLASP2 CLASP2 IL6 IL6 DACT3 DACT3 SMAD7 SMAD7 MTOR MTOR ENSNLEP00000033486 ENSNLEP00000033486 IL17RD IL17RD OLFM1 OLFM1 ENSNLEP00000032148 ENSNLEP00000032148 HPN HPN ENSNLEP00000029616 ENSNLEP00000029616 LRG1 LRG1 EZH2 EZH2 LOC100584404 LOC100584404 PHLDB2 PHLDB2 ENSNLEP00000028086 ENSNLEP00000028086 SPRY2 SPRY2 SPRED1 SPRED1 SPRY1 SPRY1 EFNA1 EFNA1 ENG ENG CLASP1 CLASP1 ENSNLEP00000024692 ENSNLEP00000024692 LDLRAD4 LDLRAD4 GCNT2 GCNT2 LOXL2 LOXL2 SMAD2 SMAD2 BAMBI BAMBI SPRED3 SPRED3 TGFB3 TGFB3 DAB2 DAB2 TGFB1I1 TGFB1I1 TCF7L2 TCF7L2 AXIN2 AXIN2 JAG1 JAG1 TGFB2 TGFB2 BMP2 BMP2 MARK1 MARK1 TGFB1 TGFB1 BMP4 BMP4 SFRP1 SFRP1 PTEN PTEN GATA3 GATA3 SMAD4 SMAD4 EPHA3 EPHA3 ISL1 ISL1 ZNF750 ZNF750 GREM1 GREM1 PDPN PDPN MAD2L2 MAD2L2 COL1A1 COL1A1 NOTCH1 NOTCH1 BCL9L BCL9L PHLDB1 PHLDB1 BMP7 BMP7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNAI1Snail family transcriptional repressor 1. (264 aa)
DAG1Dystroglycan 1. (895 aa)
SFRP2Secreted frizzled related protein 2. (280 aa)
CTNNB1Catenin beta 1. (781 aa)
ELL3Elongation factor for RNA polymerase II 3. (397 aa)
ALX1ALX homeobox 1. (326 aa)
FUZFuzzy planar cell polarity protein. (398 aa)
PAWRPro-apoptotic WT1 regulator. (340 aa)
USF3Upstream transcription factor family member 3. (2237 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (181 aa)
NKX2-1NK2 homeobox 1. (394 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1561 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
TRIM62Tripartite motif containing 62. (475 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa)
TBX20T-box transcription factor 20. (447 aa)
RGCCRegulator of cell cycle. (137 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
TBX5T-box transcription factor 5. (508 aa)
LEF1Lymphoid enhancer binding factor 1. (386 aa)
FERMT2Fermitin family member 2. (693 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (533 aa)
SPRED2Sprouty related EVH1 domain containing 2. (418 aa)
FOXA1Uncharacterized protein. (346 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
ENSNLEP00000041273Uncharacterized protein. (190 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
FOXA2Fork-head domain-containing protein. (294 aa)
MCRIP1Uncharacterized protein. (128 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
ENSNLEP00000042367PDZ_6 domain-containing protein. (254 aa)
EPHA4EPH receptor A4. (967 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
DAB2IPDAB2 interacting protein. (1159 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ENSNLEP00000045603Uncharacterized protein. (252 aa)
POFUT2Uncharacterized protein. (488 aa)
ZNF703Zinc finger protein 703. (522 aa)
SDCBPSyndecan binding protein. (318 aa)
ADIPOR1Adiponectin receptor 1. (369 aa)
CLASP2Uncharacterized protein. (1515 aa)
IL6Uncharacterized protein. (258 aa)
DACT3Uncharacterized protein. (181 aa)
SMAD7Mothers against decapentaplegic homolog. (376 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
ENSNLEP00000033486Uncharacterized protein. (126 aa)
IL17RDInterleukin 17 receptor D. (728 aa)
OLFM1Olfactomedin 1. (488 aa)
ENSNLEP00000032148LRRNT domain-containing protein. (382 aa)
HPNHepsin; Belongs to the peptidase S1 family. (431 aa)
ENSNLEP00000029616RGS domain-containing protein. (169 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
LOC100584404Uncharacterized protein. (253 aa)
PHLDB2Pleckstrin homology like domain family B member 2. (1253 aa)
ENSNLEP00000028086Fork-head domain-containing protein. (459 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
SPRED1Sprouty related EVH1 domain containing 1. (444 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (204 aa)
ENGEndoglin. (658 aa)
CLASP1Cytoplasmic linker associated protein 1. (1538 aa)
ENSNLEP00000024692Uncharacterized protein. (267 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
GCNT2Uncharacterized protein. (402 aa)
LOXL2Lysyl oxidase like 2. (710 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (247 aa)
SPRED3Uncharacterized protein. (438 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
DAB2DAB adaptor protein 2. (749 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (460 aa)
TCF7L2HMG box domain-containing protein. (534 aa)
AXIN2DIX domain-containing protein. (294 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1157 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
MARK1Non-specific serine/threonine protein kinase. (770 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
GATA3GATA binding protein 3. (444 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
EPHA3EPH receptor A3. (983 aa)
ISL1ISL LIM homeobox 1. (349 aa)
ZNF750Uncharacterized protein. (324 aa)
GREM1CTCK domain-containing protein. (143 aa)
PDPNUncharacterized protein. (175 aa)
MAD2L2HORMA domain-containing protein. (124 aa)
COL1A1Collagen type I alpha 1 chain. (1386 aa)
NOTCH1Notch receptor 1. (2451 aa)
BCL9LBCL9 like. (1338 aa)
PHLDB1Pleckstrin homology like domain family B member 1. (1381 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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