STRINGSTRING
EDN1 EDN1 INPP5K INPP5K HK2 HK2 STXBP3 STXBP3 APPL1 APPL1 ENSNLEP00000048586 ENSNLEP00000048586 TNF TNF ENSNLEP00000047446 ENSNLEP00000047446 IRS2 IRS2 IGF1 IGF1 IL1B IL1B KLF15 KLF15 SELENOS SELENOS PRKCB PRKCB ENSNLEP00000043688 ENSNLEP00000043688 ENSNLEP00000043342 ENSNLEP00000043342 NFE2L2 NFE2L2 AKT2 AKT2 CAPN10 CAPN10 APPL2 APPL2 ADIPOQ ADIPOQ OSTN OSTN YES1 YES1 GRB10 GRB10 CREBL2 CREBL2 ENSNLEP00000038378 ENSNLEP00000038378 ENSNLEP00000038125 ENSNLEP00000038125 LOC100591323 LOC100591323 SLC1A2 SLC1A2 ARPP19 ARPP19 ENSNLEP00000035777 ENSNLEP00000035777 IRS1 IRS1 LOC100605369 LOC100605369 SORBS1 SORBS1 OSBPL8 OSBPL8 PID1 PID1 PRKAG2 PRKAG2 AKT1 AKT1 ENSNLEP00000027584 ENSNLEP00000027584 C2CD5 C2CD5 FABP5 FABP5 MEF2A MEF2A RHOQ RHOQ ENSNLEP00000024736 ENSNLEP00000024736 MAPK14 MAPK14 PRKCI PRKCI G1S9G7_NOMLE G1S9G7_NOMLE RNASEL RNASEL PTH PTH NR4A3 NR4A3 INSR INSR PTPN11 PTPN11 C1QTNF12 C1QTNF12 C3 C3 PLA2G1B PLA2G1B ENPP1 ENPP1 ITLN2 ITLN2 ITLN1 ITLN1 FFAR4 FFAR4 LEP LEP CLIP3 CLIP3 ERFE ERFE TERT TERT GSK3A GSK3A FGF19 FGF19 RPS6KB1 RPS6KB1 TRIB3 TRIB3 STXBP4 STXBP4 RTN2 RTN2 BRAF BRAF GIP GIP SIRT6 SIRT6 OPN3 OPN3 OCLN OCLN FGF21 FGF21 CLTCL1 CLTCL1 POU4F2 POU4F2 EDNRA EDNRA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EDN1Endothelin 1. (211 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (372 aa)
HK2Hexokinase 2. (917 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (674 aa)
ENSNLEP00000048586FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (105 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ENSNLEP00000047446Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
IGF1IlGF domain-containing protein. (196 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
KLF15Kruppel like factor 15. (410 aa)
SELENOSUncharacterized protein. (218 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ENSNLEP00000043688Uncharacterized protein. (273 aa)
ENSNLEP00000043342Uncharacterized protein. (386 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (607 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (398 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (672 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (670 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
OSTNOsteocrin. (133 aa)
YES1Tyrosine-protein kinase. (519 aa)
GRB10Growth factor receptor bound protein 10. (612 aa)
CREBL2BZIP domain-containing protein. (193 aa)
ENSNLEP00000038378Uncharacterized protein. (91 aa)
ENSNLEP00000038125FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (114 aa)
LOC100591323Uncharacterized protein. (917 aa)
SLC1A2Amino acid transporter. (580 aa)
ARPP19cAMP regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (131 aa)
ENSNLEP00000035777Uncharacterized protein. (111 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
LOC100605369Uncharacterized protein. (571 aa)
SORBS1Uncharacterized protein. (1293 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (873 aa)
PID1Uncharacterized protein. (97 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ENSNLEP00000027584SH2 domain-containing protein. (188 aa)
C2CD5C2 calcium dependent domain containing 5. (1042 aa)
FABP5FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
MEF2AMyocyte enhancer factor 2A. (509 aa)
RHOQUncharacterized protein. (190 aa)
ENSNLEP00000024736Uncharacterized protein. (489 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
G1S9G7_NOMLEUncharacterized protein. (101 aa)
RNASELRibonuclease L. (741 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (636 aa)
INSRInsulin receptor. (1232 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
C1QTNF12C1q domain-containing protein. (213 aa)
C3Complement C3. (1424 aa)
PLA2G1BPhospholipase A(2). (148 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (827 aa)
ITLN2Uncharacterized protein. (288 aa)
ITLN1Intelectin 1. (313 aa)
FFAR4G_PROTEIN_RECEP_F1_2 domain-containing protein. (235 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
CLIP3CAP-Gly domain containing linker protein 3. (504 aa)
ERFEErythroferrone. (353 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (983 aa)
GSK3AGlycogen synthase kinase 3 alpha. (439 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
STXBP4Syntaxin binding protein 4. (539 aa)
RTN2Reticulon. (546 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
GIPGastric inhibitory polypeptide. (153 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (215 aa)
OPN3Opsin 3; Belongs to the G-protein coupled receptor 1 family. (336 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1638 aa)
POU4F2POU domain protein. (408 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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