STRINGSTRING
TGFBR1 TGFBR1 PPARG PPARG ENSNLEP00000035372 ENSNLEP00000035372 RBPMS RBPMS SDCBP SDCBP GDF15 GDF15 LOC100584404 LOC100584404 MSTN MSTN GDF3 GDF3 TGFBR2 TGFBR2 GDF6 GDF6 BMP5 BMP5 INHBA INHBA GDF7 GDF7 ACVR1 ACVR1 HFE HFE BMPR1A BMPR1A ENG ENG ENSNLEP00000024692 ENSNLEP00000024692 ACVRL1 ACVRL1 GDF11 GDF11 ACVR2A ACVR2A INHA INHA BMP10 BMP10 GDF5 GDF5 BMP6 BMP6 SMAD4 SMAD4 BMP8B BMP8B TTK TTK BMP4 BMP4 GDF9 GDF9 TGFB1 TGFB1 LOC100598046 LOC100598046 BMP2 BMP2 TGFB2 TGFB2 INHBC INHBC INHBE INHBE TGFB3 TGFB3 DAB2 DAB2 GDF2 GDF2 GDF10 GDF10 NODAL NODAL LEFTY1 LEFTY1 ENSNLEP00000042367 ENSNLEP00000042367 TWSG1 TWSG1 BMP7 BMP7 BMP15 BMP15 BMP3 BMP3 BMPR2 BMPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
ENSNLEP00000035372TGF_BETA_2 domain-containing protein. (392 aa)
RBPMSRRM domain-containing protein. (224 aa)
SDCBPSyndecan binding protein. (318 aa)
GDF15Growth differentiation factor 15. (308 aa)
LOC100584404Uncharacterized protein. (253 aa)
MSTNMyostatin. (376 aa)
GDF3Growth differentiation factor 3. (364 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
GDF6Growth differentiation factor 6. (455 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
INHBAInhibin subunit beta A. (426 aa)
GDF7Growth differentiation factor 7. (450 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (345 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
ENGEndoglin. (658 aa)
ENSNLEP00000024692Uncharacterized protein. (267 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
GDF11TGF_BETA_2 domain-containing protein. (377 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
GDF5Growth differentiation factor 5. (442 aa)
BMP6TGF_BETA_2 domain-containing protein. (125 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMP8BTGF_BETA_2 domain-containing protein. (403 aa)
TTKTTK protein kinase. (852 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
GDF9Growth differentiation factor 9. (455 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LOC100598046TGFb_propeptide domain-containing protein. (248 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
INHBCInhibin subunit beta C. (352 aa)
INHBEInhibin subunit beta E. (350 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
DAB2DAB adaptor protein 2. (749 aa)
GDF2Growth differentiation factor 2. (429 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
NODALNodal growth differentiation factor. (347 aa)
LEFTY1Left-right determination factor. (365 aa)
ENSNLEP00000042367PDZ_6 domain-containing protein. (254 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
BMP15Bone morphogenetic protein 15. (392 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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