STRINGSTRING
ENSNLEP00000030403 ENSNLEP00000030403 MSMO1 MSMO1 SREBF1 SREBF1 HMGCS1 HMGCS1 PRKAA1 PRKAA1 CYP51A1 CYP51A1 LBR LBR ENSNLEP00000039238 ENSNLEP00000039238 NPC1L1 NPC1L1 ARV1 ARV1 SC5D SC5D HMGCR HMGCR CES1 CES1 CYB5R1 CYB5R1 MVD MVD LOC100599005 LOC100599005 MVK MVK LSS LSS TM7SF2 TM7SF2 SQLE SQLE APOA5 APOA5 APOA4 APOA4 APOA1 APOA1 EBP EBP INSIG1 INSIG1 ACLY ACLY PMVK PMVK CFTR CFTR INSIG2 INSIG2 FDPS FDPS IDI2 IDI2 NSDHL NSDHL G6PD G6PD DHCR24 DHCR24 HSD17B7 HSD17B7 PRKAA2 PRKAA2 FDFT1 FDFT1 ERG28 ERG28 FAXDC2 FAXDC2 CYB5R2 CYB5R2 HMGCS2 HMGCS2 CH25H CH25H ENSNLEP00000025828 ENSNLEP00000025828 LOC100595503 LOC100595503 IDI1 IDI1 DHCR7 DHCR7 LOC100590882 LOC100590882 ENSNLEP00000029101 ENSNLEP00000029101 PRKAG2 PRKAG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSNLEP00000030403Uncharacterized protein. (222 aa)
MSMO1Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (293 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
CYP51A1Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (509 aa)
LBRLamin B receptor. (615 aa)
ENSNLEP00000039238Nudix hydrolase domain-containing protein. (183 aa)
NPC1L1NPC1 like intracellular cholesterol transporter 1. (1340 aa)
ARV1ARV1 homolog, fatty acid homeostasis modulator. (271 aa)
SC5DSterol-C5-desaturase; Belongs to the sterol desaturase family. (299 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (893 aa)
CES1Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (570 aa)
CYB5R1NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa)
MVDDiphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (379 aa)
LOC100599005Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (567 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (376 aa)
LSSTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (672 aa)
TM7SF2Transmembrane 7 superfamily member 2. (380 aa)
SQLESqualene epoxidase. (574 aa)
APOA5Apolipoprotein A5. (366 aa)
APOA4Apolipoprotein A4. (392 aa)
APOA1Apolipoprotein A1. (267 aa)
EBPEXPERA domain-containing protein. (230 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (274 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1103 aa)
PMVKPhosphomevalonate kinase. (192 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1480 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
FDPSFarnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (420 aa)
IDI2Isopentenyl-diphosphate delta isomerase 2. (223 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (373 aa)
G6PDUncharacterized protein. (452 aa)
DHCR2424-dehydrocholesterol reductase. (514 aa)
HSD17B7Hydroxysteroid 17-beta dehydrogenase 7. (366 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
FDFT1Farnesyl-diphosphate farnesyltransferase 1. (480 aa)
ERG28Ergosterol biosynthesis 28 homolog. (140 aa)
FAXDC2Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (310 aa)
CYB5R2NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (276 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
CH25HCholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (272 aa)
ENSNLEP00000025828Uncharacterized protein. (244 aa)
LOC100595503FAD-binding FR-type domain-containing protein. (276 aa)
IDI1Nudix hydrolase domain-containing protein. (227 aa)
DHCR77-dehydrocholesterol reductase. (475 aa)
LOC100590882Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (371 aa)
ENSNLEP00000029101Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (385 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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