STRINGSTRING
TSC1 TSC1 PIP4K2A PIP4K2A IL4 IL4 SESN1 SESN1 SIRT1 SIRT1 SNX7 SNX7 VPS13D VPS13D G1RD82_NOMLE G1RD82_NOMLE RAB3GAP1 RAB3GAP1 ULK1 ULK1 VDAC1 VDAC1 RUFY4 RUFY4 PIP4K2C PIP4K2C ATG2A ATG2A C9orf72 C9orf72 KIAA1324 KIAA1324 RIPK2 RIPK2 MAPK3 MAPK3 WIPI1 WIPI1 NOD2 NOD2 SNX4 SNX4 PIP4K2B PIP4K2B SPTLC1 SPTLC1 HTT HTT HSPB8 HSPB8 FYCO1 FYCO1 LRSAM1 LRSAM1 PINK1 PINK1 CALCOCO2 CALCOCO2 SESN2 SESN2 WDR24 WDR24 ENSNLEP00000025893 ENSNLEP00000025893 SNX30 SNX30 UVRAG UVRAG LOC100597720 LOC100597720 ENSNLEP00000031088 ENSNLEP00000031088 BNIP3 BNIP3 ENSNLEP00000032971 ENSNLEP00000032971 GPSM1 GPSM1 OPTN OPTN PAFAH1B2 PAFAH1B2 TSC2 TSC2 LACRT LACRT GNAI3 GNAI3 SUPT5H SUPT5H SCOC SCOC ENSNLEP00000043930 ENSNLEP00000043930 KDR KDR HMOX1 HMOX1 LOC100593029 LOC100593029 ENSNLEP00000047083 ENSNLEP00000047083 SPTLC2 SPTLC2 TRIM13 TRIM13 DCN DCN SESN3 SESN3 HIF1A HIF1A SLC25A4 SLC25A4 MOAP1 MOAP1 TBK1 TBK1 WAC WAC BAG3 BAG3 LARP1 LARP1 BNIP3L BNIP3L RNF31 RNF31 EPM2A EPM2A NOD1 NOD1 SLC25A5 SLC25A5 IKBKG IKBKG SMCR8 SMCR8 AMBRA1 AMBRA1 RAB3GAP2 RAB3GAP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TSC1TSC complex subunit 1. (1164 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (371 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (135 aa)
SESN1Sestrin 1. (551 aa)
SIRT1Sirtuin 1. (734 aa)
SNX7Sorting nexin 7. (451 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4387 aa)
G1RD82_NOMLEUncharacterized protein. (342 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (980 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1049 aa)
VDAC1Voltage dependent anion channel 1. (282 aa)
RUFY4RUN domain-containing protein. (466 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (421 aa)
ATG2AAutophagy related 2A. (1881 aa)
C9orf72Uncharacterized protein. (317 aa)
KIAA1324KIAA1324. (918 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
MAPK3Mitogen-activated protein kinase. (278 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (419 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
SNX4Sorting nexin 4. (442 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (513 aa)
HTTHuntingtin. (3048 aa)
HSPB8Heat shock protein family B (small) member 8; Belongs to the small heat shock protein (HSP20) family. (196 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1478 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (723 aa)
PINK1Protein kinase domain-containing protein. (563 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (470 aa)
SESN2Sestrin 2. (470 aa)
WDR24WD repeat domain 24. (903 aa)
ENSNLEP00000025893Uncharacterized protein. (271 aa)
SNX30Sorting nexin family member 30. (437 aa)
UVRAGUV radiation resistance associated. (699 aa)
LOC100597720Uncharacterized protein. (278 aa)
ENSNLEP00000031088Protein kinase domain-containing protein. (557 aa)
BNIP3Uncharacterized protein. (231 aa)
ENSNLEP00000032971Uncharacterized protein. (271 aa)
GPSM1G protein signaling modulator 1. (701 aa)
OPTNOptineurin. (577 aa)
PAFAH1B2Platelet activating factor acetylhydrolase 1b catalytic subunit 2. (229 aa)
TSC2TSC complex subunit 2. (1777 aa)
LACRTUncharacterized protein. (102 aa)
GNAI3G protein subunit alpha i3. (354 aa)
SUPT5HTranscription elongation factor SPT5. (1072 aa)
SCOCShort coiled-coil protein. (159 aa)
ENSNLEP00000043930Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (265 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
LOC100593029PX domain-containing protein. (372 aa)
ENSNLEP00000047083Uncharacterized protein. (267 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (566 aa)
TRIM13Tripartite motif containing 13. (410 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
SESN3Sestrin 3. (520 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
SLC25A4Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (366 aa)
MOAP1Modulator of apoptosis 1. (351 aa)
TBK1TANK binding kinase 1. (729 aa)
WACWW domain containing adaptor with coiled-coil. (647 aa)
BAG3BCL2 associated athanogene 3. (574 aa)
LARP1La ribonucleoprotein domain family member 1. (1007 aa)
BNIP3LBCL2 interacting protein 3 like. (219 aa)
RNF31Uncharacterized protein. (1072 aa)
EPM2AEPM2A glucan phosphatase, laforin. (331 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
IKBKGNEMO domain-containing protein. (173 aa)
SMCR8SMCR8-C9orf72 complex subunit. (937 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1284 aa)
RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2. (1390 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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