31 items (Nomascus leucogenys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

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Your Input:
	RPS6KA5	Ribosomal protein S6 kinase. (797 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
	VRK1	VRK serine/threonine kinase 1; Belongs to the protein kinase superfamily. (396 aa)
	NEK11	NIMA related kinase 11. (645 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
	MST1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
	AURKA	Aurora kinase A; Belongs to the protein kinase superfamily. (403 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3055 aa)
	BAZ1B	Bromodomain adjacent to zinc finger domain 1B. (1483 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	CCNA2	Cyclin A2; Belongs to the cyclin family. (431 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
	HIPK4	Homeodomain interacting protein kinase 4. (564 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (552 aa)
	HASPIN	Histone H3 associated protein kinase. (790 aa)
	PKN1	Protein kinase domain-containing protein. (839 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	VRK3	VRK serine/threonine kinase 3. (474 aa)
	DCAF1	DDB1 and CUL4 associated factor 1. (1507 aa)
	AURKC	Aurora kinase C; Belongs to the protein kinase superfamily. (309 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (311 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (574 aa)
	RPS6KA4	Ribosomal protein S6 kinase. (743 aa)
	ENSNLEP00000036861	Uncharacterized protein. (119 aa)
	AURKB	Uncharacterized protein. (123 aa)
	DRD1	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	CHEK1	Checkpoint kinase 1. (492 aa)
	SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
	VRK2	VRK serine/threonine kinase 2. (509 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	INCENP	Inner centromere protein. (920 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	CCNA2	ENSNLEP00000008823	ENSNLEP00000011369	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin A2; Belongs to the cyclin family.	0.745
ATM	CDK1	ENSNLEP00000008823	ENSNLEP00000028052	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.715
ATM	CDK2	ENSNLEP00000008823	ENSNLEP00000033383	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.950
ATM	CHEK1	ENSNLEP00000008823	ENSNLEP00000040376	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Checkpoint kinase 1.	0.890
ATM	HIPK4	ENSNLEP00000008823	ENSNLEP00000017115	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Homeodomain interacting protein kinase 4.	0.460
ATM	JAK2	ENSNLEP00000008823	ENSNLEP00000010932	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.523
ATM	PRKAA1	ENSNLEP00000008823	ENSNLEP00000034028	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Non-specific serine/threonine protein kinase.	0.600
AURKA	AURKB	ENSNLEP00000008572	ENSNLEP00000038564	Aurora kinase A; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.672
AURKA	AURKC	ENSNLEP00000008572	ENSNLEP00000030383	Aurora kinase A; Belongs to the protein kinase superfamily.	Aurora kinase C; Belongs to the protein kinase superfamily.	0.726
AURKA	CCNA2	ENSNLEP00000008572	ENSNLEP00000011369	Aurora kinase A; Belongs to the protein kinase superfamily.	Cyclin A2; Belongs to the cyclin family.	0.892
AURKA	CDK1	ENSNLEP00000008572	ENSNLEP00000028052	Aurora kinase A; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.932
AURKA	CDK2	ENSNLEP00000008572	ENSNLEP00000033383	Aurora kinase A; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.843
AURKA	CHEK1	ENSNLEP00000008572	ENSNLEP00000040376	Aurora kinase A; Belongs to the protein kinase superfamily.	Checkpoint kinase 1.	0.522
AURKA	HASPIN	ENSNLEP00000008572	ENSNLEP00000022714	Aurora kinase A; Belongs to the protein kinase superfamily.	Histone H3 associated protein kinase.	0.520
AURKA	INCENP	ENSNLEP00000008572	ENSNLEP00000047341	Aurora kinase A; Belongs to the protein kinase superfamily.	Inner centromere protein.	0.965
AURKB	AURKA	ENSNLEP00000038564	ENSNLEP00000008572	Uncharacterized protein.	Aurora kinase A; Belongs to the protein kinase superfamily.	0.672
AURKB	AURKC	ENSNLEP00000038564	ENSNLEP00000030383	Uncharacterized protein.	Aurora kinase C; Belongs to the protein kinase superfamily.	0.599
AURKB	CCNA2	ENSNLEP00000038564	ENSNLEP00000011369	Uncharacterized protein.	Cyclin A2; Belongs to the cyclin family.	0.869
AURKB	CDK1	ENSNLEP00000038564	ENSNLEP00000028052	Uncharacterized protein.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.925
AURKB	CDK2	ENSNLEP00000038564	ENSNLEP00000033383	Uncharacterized protein.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.647

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