STRINGSTRING
CD4 CD4 LOC100591987 LOC100591987 GRIN2B GRIN2B ITPR1 ITPR1 P2RY12 P2RY12 ACKR4 ACKR4 NCALD NCALD EIF2AK3 EIF2AK3 HPCA HPCA CACNA1C CACNA1C TRPM5 TRPM5 DMPK DMPK ADGRB2 ADGRB2 ZAP70 ZAP70 POMC POMC CXCR3 CXCR3 G1QJP9_NOMLE G1QJP9_NOMLE MCOLN1 MCOLN1 FKBP1B FKBP1B EDN1 EDN1 SYK SYK KSR2 KSR2 G1QH14_NOMLE G1QH14_NOMLE SPHK1 SPHK1 ADGRL1 ADGRL1 HTR2B HTR2B LOC100606903 LOC100606903 PTGDR2 PTGDR2 ATP2A2 ATP2A2 NFATC3 NFATC3 CCR7 CCR7 RCAN1 RCAN1 KDR KDR ENSNLEP00000044067 ENSNLEP00000044067 P2RX4 P2RX4 RYR2 RYR2 CCR9 CCR9 AGTR1 AGTR1 CLIC2 CLIC2 CX3CR1 CX3CR1 CD3E CD3E CAMKK2 CAMKK2 CCR6 CCR6 GRIN2A GRIN2A LAT LAT RCAN2 RCAN2 NFATC4 NFATC4 TRPM8 TRPM8 LOC100593010 LOC100593010 NMUR1 NMUR1 ITPR3 ITPR3 NFATC1 NFATC1 FIS1 FIS1 CAMK2D CAMK2D LOC100584149 LOC100584149 LACRT LACRT TRPM2 TRPM2 SELE SELE DMTN DMTN CXCR4 CXCR4 GRIN1 GRIN1 PPP1R9B PPP1R9B RYR1 RYR1 TRPM4 TRPM4 CXCR5 CXCR5 MCOLN3 MCOLN3 CCL20 CCL20 MCTP1 MCTP1 NFATC2 NFATC2 ITPR2 ITPR2 DEFB1 DEFB1 DMD DMD PRKAA1 PRKAA1 MTOR MTOR GRIN2D GRIN2D PPP3CA PPP3CA ADA ADA GRM5 GRM5 TENM2 TENM2 SLC8A1 SLC8A1 CALM1 CALM1 PLN PLN PPP3CB PPP3CB PPP3R1 PPP3R1 SGCD SGCD TNFSF11 TNFSF11 PRKACA PRKACA ENSNLEP00000025216 ENSNLEP00000025216 P2RY11 P2RY11 ASPH ASPH PRNP PRNP BHLHA15 BHLHA15 ACKR2 ACKR2 CCR4 CCR4 CHRM3 CHRM3 NR5A2 NR5A2 PTPRC PTPRC LRRK2 LRRK2 TMEM38B TMEM38B NR5A1 NR5A1 TRPV1 TRPV1 AVPR1A AVPR1A NMUR2 NMUR2 MCU MCU EDNRB EDNRB ANK2 ANK2 PPP1R9A PPP1R9A PPP3CC PPP3CC GSTO1 GSTO1 SELP SELP ATP1B1 ATP1B1 PTPRJ PTPRJ SAMD3 SAMD3 HPCAL1 HPCAL1 CASQ1 CASQ1 PLCE1 PLCE1 MCTP2 MCTP2 EDN2 EDN2 ZMPSTE24 ZMPSTE24 VCAM1 VCAM1 CCR10 CCR10 TRPA1 TRPA1 HOMER2 HOMER2 TNNI3 TNNI3 RYR3 RYR3 ACKR3 ACKR3 PLCG2 PLCG2 GRIN2C GRIN2C MCOLN2 MCOLN2 PTGFR PTGFR PKD2 PKD2 SLC9A1 SLC9A1 LOC100592336 LOC100592336 RCAN3 RCAN3 SAMD14 SAMD14 LAT2 LAT2 MAPK7 MAPK7 CCRL2 CCRL2 RASA3 RASA3 BTK BTK LOC100580192 LOC100580192 TPCN2 TPCN2 PLCG1 PLCG1 TBC1D10C TBC1D10C CCR1 CCR1 XCR1 XCR1 TMEM38A TMEM38A NFAT5 NFAT5 TREML1 TREML1 HRC HRC CASQ2 CASQ2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD4CD4 molecule. (458 aa)
LOC100591987Phospholipase A2. (760 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1335 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
P2RY12Purinergic receptor P2Y12. (342 aa)
ACKR4Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (350 aa)
NCALDNeurocalcin delta. (193 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1120 aa)
HPCAHippocalcin. (193 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1985 aa)
TRPM5Transient receptor potential cation channel subfamily M member 5. (1069 aa)
DMPKDM1 protein kinase. (630 aa)
ADGRB2Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1546 aa)
ZAP70Tyrosine-protein kinase. (704 aa)
POMCProopiomelanocortin. (243 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
G1QJP9_NOMLEPeptidase S1 domain-containing protein. (178 aa)
MCOLN1Mucolipin 1. (580 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
EDN1Endothelin 1. (211 aa)
SYKTyrosine-protein kinase. (532 aa)
KSR2Kinase suppressor of ras 2. (950 aa)
G1QH14_NOMLEUncharacterized protein. (500 aa)
SPHK1DAGKc domain-containing protein. (398 aa)
ADGRL1Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family. (1479 aa)
HTR2BG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (398 aa)
LOC100606903Uncharacterized protein; Belongs to the GST superfamily. (236 aa)
PTGDR2Prostaglandin D2 receptor 2; Belongs to the G-protein coupled receptor 1 family. (396 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
NFATC3Nuclear factor of activated T cells 3. (1045 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
RCAN1Uncharacterized protein. (278 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
ENSNLEP00000044067Uncharacterized protein. (108 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
RYR2Ryanodine receptor 2. (4825 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
CLIC2Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (243 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (386 aa)
CD3ECD3e molecule. (198 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (591 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (377 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
LATLinker for activation of T cells. (264 aa)
RCAN2Regulator of calcineurin 2. (243 aa)
NFATC4Nuclear factor of activated T cells 4. (844 aa)
TRPM8Transient receptor potential cation channel subfamily M member 8. (1104 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
NMUR1Neuromedin U receptor 1. (412 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2755 aa)
NFATC1Nuclear factor of activated T cells 1. (968 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
LOC100584149Sulfotransferase; Belongs to the sulfotransferase 1 family. (267 aa)
LACRTUncharacterized protein. (102 aa)
TRPM2LSDAT_euk domain-containing protein. (1224 aa)
SELESelectin E. (612 aa)
DMTNDematin actin binding protein. (406 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (375 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (888 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (813 aa)
RYR1Ryanodine receptor 1. (4415 aa)
TRPM4Uncharacterized protein. (1010 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
MCOLN3Mucolipin 3. (553 aa)
CCL20C-C motif chemokine. (96 aa)
MCTP1Uncharacterized protein. (808 aa)
NFATC2Nuclear factor of activated T cells 2. (905 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
DEFB1Defensin beta 1. (68 aa)
DMDDystrophin. (3685 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
GRIN2DUncharacterized protein. (1096 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ADAAdenosine deaminase. (405 aa)
GRM5Glutamate metabotropic receptor 5. (1210 aa)
TENM2Teneurin transmembrane protein 2. (2774 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (972 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
PPP3CBSerine/threonine-protein phosphatase. (408 aa)
PPP3R1Uncharacterized protein. (189 aa)
SGCDSarcoglycan delta. (290 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
PRKACAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (294 aa)
ENSNLEP00000025216Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (256 aa)
P2RY11Purinergic receptor P2Y11; Belongs to the G-protein coupled receptor 1 family. (374 aa)
ASPHAspartate beta-hydroxylase. (762 aa)
PRNPMajor prion protein; Belongs to the prion family. (253 aa)
BHLHA15Basic helix-loop-helix family member a15. (189 aa)
ACKR2Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (384 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (540 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1304 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
TMEM38BTransmembrane protein 38B. (291 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. (405 aa)
NMUR2Neuromedin U receptor 2; Belongs to the G-protein coupled receptor 1 family. (403 aa)
MCUMitochondrial calcium uniporter. (352 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
ANK2Ankyrin 2. (3957 aa)
PPP1R9AProtein phosphatase 1 regulatory subunit 9A. (1374 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
GSTO1Glutathione S-transferase omega 1. (241 aa)
SELPSelectin P. (830 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1282 aa)
SAMD3Sterile alpha motif domain containing 3. (520 aa)
HPCAL1Hippocalcin like 1. (193 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (121 aa)
PLCE1Phosphoinositide phospholipase C. (2303 aa)
MCTP2Multiple C2 and transmembrane domain containing 2. (889 aa)
EDN2Endothelin 2. (177 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
CCR10C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (362 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1094 aa)
HOMER2Homer scaffold protein 2. (310 aa)
TNNI3Troponin I3, cardiac type. (210 aa)
RYR3Ryanodine receptor 3. (4794 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1218 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1119 aa)
MCOLN2Mucolipin 2. (566 aa)
PTGFRProstaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (921 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (809 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
RCAN3RCAN family member 3. (241 aa)
SAMD14SAM domain-containing protein. (388 aa)
LAT2Linker for activation of T cells family member 2. (244 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
CCRL2C-C motif chemokine receptor like 2; Belongs to the G-protein coupled receptor 1 family. (356 aa)
RASA3RAS p21 protein activator 3. (816 aa)
BTKTyrosine-protein kinase. (659 aa)
LOC100580192G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (351 aa)
TPCN2Uncharacterized protein. (735 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
TBC1D10CTBC1 domain family member 10C. (446 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
XCR1X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
TMEM38ATransmembrane protein 38A. (299 aa)
NFAT5Nuclear factor of activated T cells 5. (1547 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (311 aa)
HRCHistidine rich calcium binding protein. (696 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (373 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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