83 items (Nomascus leucogenys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CRK	Uncharacterized protein. (252 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	NEUROD1	Neurogenic differentiation factor. (356 aa)
	TSKU	Tsukushi, small leucine rich proteoglycan. (354 aa)
	LOC100583245	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (224 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1199 aa)
	ENSNLEP00000043421	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (393 aa)
	YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	PLXNA3	Plexin A3. (1828 aa)
	PHLPP2	PH domain and leucine rich repeat protein phosphatase 2. (1317 aa)
	LOC100606563	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (346 aa)
	DRD1	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	TENT2	Terminal nucleotidyltransferase 2. (484 aa)
	PPP1R9B	Protein phosphatase 1 regulatory subunit 9B. (813 aa)
	ENSNLEP00000036861	Uncharacterized protein. (119 aa)
	BBS1	Uncharacterized protein. (540 aa)
	LOC100593615	TPR_REGION domain-containing protein. (160 aa)
	LEF1	Lymphoid enhancer binding factor 1. (386 aa)
	ENSNLEP00000033486	Uncharacterized protein. (126 aa)
	FEZF2	FEZ family zinc finger 2. (446 aa)
	EMX2	Empty spiracles homeobox 2. (238 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
	HTR5A	5-hydroxytryptamine receptor 5A. (357 aa)
	KIRREL3	Kirre like nephrin family adhesion molecule 3. (773 aa)
	PTPRS	Protein tyrosine phosphatase receptor type S. (1924 aa)
	DLX1	Distal-less homeobox 1. (255 aa)
	HSD3B2	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. (372 aa)
	DLX2	Distal-less homeobox 2. (322 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
	ENSNLEP00000026090	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (258 aa)
	ENSNLEP00000025191	Uncharacterized protein. (573 aa)
	LOC100596087	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (386 aa)
	BTG2	BTG anti-proliferation factor 2. (158 aa)
	ENSNLEP00000024712	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (371 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	KCNA1	Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
	CDK5R2	Cyclin-dependent kinase 5 activator. (367 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1241 aa)
	KIF14	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1648 aa)
	LRP8	LDL receptor related protein 8. (924 aa)
	FAM205A	Family with sequence similarity 205 member A. (1334 aa)
	SRD5A2	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
	ALK	Uncharacterized protein. (1134 aa)
	NEUROD6	Neurogenic differentiation factor. (337 aa)
	DAB1	DAB adaptor protein 1. (588 aa)
	LMX1A	Uncharacterized protein. (311 aa)
	DCX	Doublecortin. (408 aa)
	MKKS	McKusick-Kaufman syndrome. (570 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	BBS4	Bardet-Biedl syndrome 4. (518 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (422 aa)
	SEMA6B	Semaphorin 6B; Belongs to the semaphorin family. (857 aa)
	TSC1	TSC complex subunit 1. (1164 aa)
	UQCRQ	Ubiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
	BCAN	Brevican. (912 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (683 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	SRD5A1	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
	RELN	Reelin. (3460 aa)
	UBA6	Ubiquitin like modifier activating enzyme 6. (1052 aa)
	EPHA5	EPH receptor A5. (1038 aa)
	ANXA3	Annexin. (323 aa)
	FEZ1	Fasciculation and elongation protein zeta 1. (392 aa)
	SLC32A1	Solute carrier family 32 member 1. (427 aa)
	EIF2B5	Eukaryotic translation initiation factor 2B subunit epsilon. (721 aa)
	DCLK2	Doublecortin like kinase 2. (783 aa)
	HSD3B1	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (373 aa)
	ATAT1	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (423 aa)
	SRF	Serum response factor. (508 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
	OGDH	Oxoglutarate dehydrogenase. (1038 aa)
	NKX2-1	NK2 homeobox 1. (394 aa)
	TMEM108	Transmembrane protein 108. (518 aa)
	NF2	Neurofibromin 2. (595 aa)
	GLI3	GLI family zinc finger 3. (1502 aa)
	ZIC3	Uncharacterized protein. (360 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	ZIC1	Zic family member 1. (451 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (721 aa)
	RARA	Retinoic acid receptor alpha. (458 aa)
	G1QH35_NOMLE	Homeobox domain-containing protein. (286 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALK	CRK	ENSNLEP00000018753	ENSNLEP00000000851	Uncharacterized protein.	Uncharacterized protein.	0.436
ALK	CRKL	ENSNLEP00000018753	ENSNLEP00000000117	Uncharacterized protein.	CRK like proto-oncogene, adaptor protein.	0.578
ALK	ENSNLEP00000033486	ENSNLEP00000018753	ENSNLEP00000033486	Uncharacterized protein.	Uncharacterized protein.	0.482
ALK	PTEN	ENSNLEP00000018753	ENSNLEP00000014741	Uncharacterized protein.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.596
BBS1	BBS2	ENSNLEP00000036650	ENSNLEP00000002656	Uncharacterized protein.	Bardet-Biedl syndrome 2 protein homolog.	0.999
BBS1	BBS4	ENSNLEP00000036650	ENSNLEP00000017129	Uncharacterized protein.	Bardet-Biedl syndrome 4.	0.990
BBS1	LOC100593615	ENSNLEP00000036650	ENSNLEP00000036166	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.986
BBS1	SMO	ENSNLEP00000036650	ENSNLEP00000015269	Uncharacterized protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.793
BBS2	BBS1	ENSNLEP00000002656	ENSNLEP00000036650	Bardet-Biedl syndrome 2 protein homolog.	Uncharacterized protein.	0.999
BBS2	BBS4	ENSNLEP00000002656	ENSNLEP00000017129	Bardet-Biedl syndrome 2 protein homolog.	Bardet-Biedl syndrome 4.	0.978
BBS2	LOC100593615	ENSNLEP00000002656	ENSNLEP00000036166	Bardet-Biedl syndrome 2 protein homolog.	TPR_REGION domain-containing protein.	0.974
BBS2	MKKS	ENSNLEP00000002656	ENSNLEP00000017601	Bardet-Biedl syndrome 2 protein homolog.	McKusick-Kaufman syndrome.	0.512
BBS2	SMO	ENSNLEP00000002656	ENSNLEP00000015269	Bardet-Biedl syndrome 2 protein homolog.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.668
BBS4	BBS1	ENSNLEP00000017129	ENSNLEP00000036650	Bardet-Biedl syndrome 4.	Uncharacterized protein.	0.990
BBS4	BBS2	ENSNLEP00000017129	ENSNLEP00000002656	Bardet-Biedl syndrome 4.	Bardet-Biedl syndrome 2 protein homolog.	0.978
BBS4	SMO	ENSNLEP00000017129	ENSNLEP00000015269	Bardet-Biedl syndrome 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.563
CDK5	CDK5R2	ENSNLEP00000005013	ENSNLEP00000022599	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 5 activator.	0.968
CDK5	CDK6	ENSNLEP00000005013	ENSNLEP00000024323	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.400
CDK5	DCX	ENSNLEP00000005013	ENSNLEP00000017684	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Doublecortin.	0.414
CDK5	GSK3B	ENSNLEP00000005013	ENSNLEP00000026237	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.462

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