(99 nodes) Gland morphogenesis network (Nomascus leucogenys)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	TGM2	Transglutaminase 2. (668 aa)
	LRP5	LDL receptor related protein 5. (1510 aa)
	DAG1	Dystroglycan 1. (895 aa)
	MST1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
	LAMA1	Laminin subunit alpha 1. (3033 aa)
	TWSG1	Twisted gastrulation BMP signaling modulator 1. (223 aa)
	BMP7	Bone morphogenetic protein 7. (430 aa)
	PGR	Uncharacterized protein. (339 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	IGFBP5	Insulin like growth factor binding protein 5. (272 aa)
	BSX	Brain specific homeobox. (232 aa)
	EPHA2	EPH receptor A2. (976 aa)
	NOTCH1	Notch receptor 1. (2451 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (744 aa)
	TGFA	Transforming growth factor alpha. (166 aa)
	CSF1R	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
	SRC	Tyrosine-protein kinase. (537 aa)
	SLC9A3R1	Uncharacterized protein. (276 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	ARG1	Arginase. (322 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	SEMA3C	Semaphorin 3C; Belongs to the semaphorin family. (751 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	SOSTDC1	Sclerostin domain containing 1. (230 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	PTCH1	Patched 1. (1446 aa)
	TNC	Tenascin C. (2207 aa)
	FGFR2	Fibroblast growth factor receptor. (820 aa)
	STAT6	Signal transducer and activator of transcription. (842 aa)
	VDR	Vitamin D receptor. (427 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (901 aa)
	SOX9	SRY-box transcription factor 9. (510 aa)
	CSMD2	CUB and Sushi multiple domains 2. (3507 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	LRP5L	Uncharacterized protein. (150 aa)
	NKX3-1	NK3 homeobox 1. (230 aa)
	SERPINB5	Serpin family B member 5; Belongs to the serpin family. (375 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	SELENOH	Selenoprotein H. (121 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	NFIB	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (487 aa)
	EDAR	Ectodysplasin A receptor. (478 aa)
	HOXA13	Homeobox domain-containing protein. (227 aa)
	EGFR	Receptor protein-tyrosine kinase. (1206 aa)
	PLAG1	PLAG1 zinc finger. (500 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (522 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	EDA	Uncharacterized protein. (145 aa)
	ELF3	E74 like ETS transcription factor 3. (357 aa)
	CSMD1	CUB and Sushi multiple domains 1. (3565 aa)
	FEM1B	Fem-1 homolog B. (627 aa)
	AREG	EGF-like domain-containing protein. (274 aa)
	FOXA1	Uncharacterized protein. (346 aa)
	LAMA5	Laminin subunit alpha 5. (3418 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	HOXD13	Homeobox D13. (306 aa)
	PAX6	Uncharacterized protein. (456 aa)
	KDM5B	Lysine demethylase 5B. (1529 aa)
	NKX2-3	NK2 homeobox 3. (363 aa)
	LRRC1	Leucine rich repeat containing 1. (503 aa)
	PML	Uncharacterized protein. (873 aa)
	NRG3	Neuregulin 3. (720 aa)
	IL6	Uncharacterized protein. (258 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (744 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	ENSNLEP00000047852	Laminin N-terminal domain-containing protein. (447 aa)
	RARG	Retinoic acid receptor gamma. (441 aa)
	TBX2	T-box transcription factor 2. (647 aa)
	MSN	Moesin. (566 aa)
	AR	Uncharacterized protein. (392 aa)
	G1QIV4_NOMLE	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (253 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1558 aa)
	PLXNA1	Plexin A1. (1880 aa)
	MMP2	Matrix metallopeptidase 2. (647 aa)
	MKI67	Marker of proliferation Ki-67. (3255 aa)
	CCL11	C-C motif chemokine. (97 aa)
	SCRIB	Scribble planar cell polarity protein. (1449 aa)
	HOXB13	Homeobox B13. (284 aa)
	GDF7	Growth differentiation factor 7. (450 aa)
	FGL1	Fibrinogen like 1. (312 aa)
	GLI3	GLI family zinc finger 3. (1502 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
	CYP7B1	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (506 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	ESRP2	Epithelial splicing regulatory protein 2. (717 aa)
	PLXND1	Plexin D1. (1603 aa)
	NOTCH2	Notch receptor 2. (2444 aa)
	CAPN1	Calpain 1; Belongs to the peptidase C2 family. (692 aa)
	DDR1	Discoidin domain receptor tyrosine kinase 1. (913 aa)
	DUOX2	Dual oxidase 2. (1548 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	BCL2	ENSNLEP00000000665	ENSNLEP00000036597	Uncharacterized protein.	BCL2 apoptosis regulator.	0.461
AR	EGFR	ENSNLEP00000000665	ENSNLEP00000035792	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.681
AR	ESR1	ENSNLEP00000000665	ENSNLEP00000018707	Uncharacterized protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.824
AR	FOXA1	ENSNLEP00000000665	ENSNLEP00000040724	Uncharacterized protein.	Uncharacterized protein.	0.952
AR	HOXB13	ENSNLEP00000000665	ENSNLEP00000003131	Uncharacterized protein.	Homeobox B13.	0.641
AR	IL6	ENSNLEP00000000665	ENSNLEP00000047139	Uncharacterized protein.	Uncharacterized protein.	0.450
AR	KDM5B	ENSNLEP00000000665	ENSNLEP00000044405	Uncharacterized protein.	Lysine demethylase 5B.	0.573
AR	MED1	ENSNLEP00000000665	ENSNLEP00000000991	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.693
AR	NKX3-1	ENSNLEP00000000665	ENSNLEP00000030995	Uncharacterized protein.	NK3 homeobox 1.	0.741
AR	PGR	ENSNLEP00000000665	ENSNLEP00000008712	Uncharacterized protein.	Uncharacterized protein.	0.710
AR	SRC	ENSNLEP00000000665	ENSNLEP00000048569	Uncharacterized protein.	Tyrosine-protein kinase.	0.919
AREG	CCL11	ENSNLEP00000040124	ENSNLEP00000001763	EGF-like domain-containing protein.	C-C motif chemokine.	0.425
AREG	CSF1R	ENSNLEP00000040124	ENSNLEP00000012479	EGF-like domain-containing protein.	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.671
AREG	EGFR	ENSNLEP00000040124	ENSNLEP00000035792	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.997
AREG	EPHA2	ENSNLEP00000040124	ENSNLEP00000009392	EGF-like domain-containing protein.	EPH receptor A2.	0.699
AREG	ESR1	ENSNLEP00000040124	ENSNLEP00000018707	EGF-like domain-containing protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.487
AREG	FGF7	ENSNLEP00000040124	ENSNLEP00000007476	EGF-like domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.513
AREG	FGF8	ENSNLEP00000040124	ENSNLEP00000018112	EGF-like domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.434
AREG	FGFR2	ENSNLEP00000040124	ENSNLEP00000020533	EGF-like domain-containing protein.	Fibroblast growth factor receptor.	0.773
AREG	FOXA1	ENSNLEP00000040124	ENSNLEP00000040724	EGF-like domain-containing protein.	Uncharacterized protein.	0.405

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