STRINGSTRING
STXBP3 STXBP3 NOS2 NOS2 LYN LYN STXBP2 STXBP2 SLC16A2 SLC16A2 ACVR1C ACVR1C FKBP1B FKBP1B EDN1 EDN1 CTBP2 CTBP2 CPLX2 CPLX2 RPH3AL RPH3AL SYK SYK PDX1 PDX1 ILDR1 ILDR1 RPH3A RPH3A AQP1 AQP1 GRM4 GRM4 RBM4 RBM4 HIF1A HIF1A NEUROD1 NEUROD1 ENSNLEP00000047725 ENSNLEP00000047725 SYT2 SYT2 IL6 IL6 DGKI DGKI ABCC4 ABCC4 HNF1A HNF1A LRRC1 LRRC1 PIP5K1C PIP5K1C UNC13A UNC13A FOXD1 FOXD1 ENSNLEP00000044067 ENSNLEP00000044067 PARK7 PARK7 CPLX3 CPLX3 SYT5 SYT5 PTPRN2 PTPRN2 TBX3 TBX3 DVL1 DVL1 ENSNLEP00000041886 ENSNLEP00000041886 PCLO PCLO EDN3 EDN3 ILDR2 ILDR2 ASIC1 ASIC1 HNF1B HNF1B NF1 NF1 SLC30A8 SLC30A8 RIMS1 RIMS1 UNC13B UNC13B NRXN1 NRXN1 SYT7 SYT7 UNC13C UNC13C ENSNLEP00000038144 ENSNLEP00000038144 ENSNLEP00000036861 ENSNLEP00000036861 ENSNLEP00000036455 ENSNLEP00000036455 FZD4 FZD4 SNAP23 SNAP23 STX1B STX1B PTPRN PTPRN ENSNLEP00000034296 ENSNLEP00000034296 DNAJC5 DNAJC5 STX1A STX1A LIN7C LIN7C SYNJ1 SYNJ1 SREBF1 SREBF1 ENSNLEP00000031088 ENSNLEP00000031088 PSEN1 PSEN1 ENSNLEP00000029188 ENSNLEP00000029188 STX3 STX3 PORCN PORCN LIN7A LIN7A PPFIA3 PPFIA3 SNAPIN SNAPIN PRRT2 PRRT2 LOC100581641 LOC100581641 RESP18 RESP18 PDZD11 PDZD11 ENSNLEP00000026359 ENSNLEP00000026359 RAB11FIP2 RAB11FIP2 SYN1 SYN1 PINK1 PINK1 SMAD2 SMAD2 M3ZA63_NOMLE M3ZA63_NOMLE SELENOT SELENOT GPR68 GPR68 MC4R MC4R GPR119 GPR119 PTGS2 PTGS2 NR4A1 NR4A1 ADM ADM SYT9 SYT9 TOR2A TOR2A NIBAN2 NIBAN2 P2RX1 P2RX1 ABCA1 ABCA1 PRKCE PRKCE NRXN3 NRXN3 CAMK2G CAMK2G EDNRB EDNRB CCDC186 CCDC186 STX4 STX4 P2RX7 P2RX7 HRH3 HRH3 VIP VIP GHRHR GHRHR STX11 STX11 SNAP25 SNAP25 SNCA SNCA SNAP47 SNAP47 LTBP4 LTBP4 SYT8 SYT8 SLC16A10 SLC16A10 FFAR4 FFAR4 CYB5R4 CYB5R4 LEP LEP RIMS3 RIMS3 PPT1 PPT1 CADPS2 CADPS2 GATA3 GATA3 WNK4 WNK4 CADPS CADPS UBE2Q1 UBE2Q1 TACR2 TACR2 GLP1R GLP1R SYT4 SYT4 RAB44 RAB44 ECRG4 ECRG4 BRSK1 BRSK1 RAB11FIP5 RAB11FIP5 RAB1A RAB1A SV2A SV2A G1RE82_NOMLE G1RE82_NOMLE WLS WLS GNRHR GNRHR CPLX4 CPLX4 STX2 STX2 DOC2A DOC2A BTK BTK SYTL4 SYTL4 SNX19 SNX19 ERC2 ERC2 NT5DC2 NT5DC2 CREB1 CREB1 ADCYAP1 ADCYAP1 LOC105738356 LOC105738356 GAL GAL NT5DC3 NT5DC3 SLC44A4 SLC44A4 SLC32A1 SLC32A1 SYT12 SYT12 GHRH GHRH RAB3A RAB3A BLOC1S6 BLOC1S6 RAPGEF4 RAPGEF4 NLGN1 NLGN1 GHSR GHSR SEPTIN5 SEPTIN5 ACVR2B ACVR2B SMPD3 SMPD3 NRXN2 NRXN2 SYT1 SYT1 LIN7B LIN7B SYN3 SYN3 SYN2 SYN2 CARTPT CARTPT GHRL GHRL EXOC3L1 EXOC3L1 CDK5 CDK5 RAP1A RAP1A RIMS2 RIMS2 SUCNR1 SUCNR1 CDK16 CDK16 INHBA INHBA TRPV6 TRPV6 OTOF OTOF BRAF BRAF TRPV4 TRPV4 TMF1 TMF1 SCRIB SCRIB PCSK5 PCSK5 IL1RN IL1RN RAB11B RAB11B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
LYNTyrosine-protein kinase. (512 aa)
STXBP2Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family. (579 aa)
SLC16A2MFS domain-containing protein. (442 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (496 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
EDN1Endothelin 1. (211 aa)
CTBP2C-terminal binding protein 2. (957 aa)
CPLX2Complexin 2. (134 aa)
RPH3ALRabphilin 3A like (without C2 domains). (314 aa)
SYKTyrosine-protein kinase. (532 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
ILDR1Immunoglobulin like domain containing receptor 1. (505 aa)
RPH3ARabphilin 3A. (693 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
GRM4Glutamate metabotropic receptor 4. (888 aa)
RBM4RNA binding motif protein 4. (364 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
ENSNLEP00000047725PXA domain-containing protein. (903 aa)
SYT2Synaptotagmin 2. (419 aa)
IL6Uncharacterized protein. (258 aa)
DGKIDiacylglycerol kinase. (1026 aa)
ABCC4ATP binding cassette subfamily C member 4. (1321 aa)
HNF1AUncharacterized protein. (562 aa)
LRRC1Leucine rich repeat containing 1. (503 aa)
PIP5K1CPIPK domain-containing protein. (759 aa)
UNC13AUnc-13 homolog A. (1460 aa)
FOXD1Uncharacterized protein. (241 aa)
ENSNLEP00000044067Uncharacterized protein. (108 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
CPLX3Complexin 3. (158 aa)
SYT5C2 domain-containing protein. (235 aa)
PTPRN2Protein tyrosine phosphatase receptor type N2. (1015 aa)
TBX3T-box transcription factor 3. (743 aa)
DVL1Dishevelled segment polarity protein 1. (667 aa)
ENSNLEP00000041886Ion_trans domain-containing protein; Belongs to the potassium channel family. (359 aa)
PCLOUncharacterized protein. (1217 aa)
EDN3Uncharacterized protein. (211 aa)
ILDR2IG domain-containing protein. (476 aa)
ASIC1Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (479 aa)
HNF1BHNF1 homeobox B. (557 aa)
NF1Neurofibromin 1. (2839 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1637 aa)
UNC13BUncharacterized protein. (4218 aa)
NRXN1Neurexin 1. (1547 aa)
SYT7Uncharacterized protein. (592 aa)
UNC13CC2 domain-containing protein. (135 aa)
ENSNLEP00000038144RRM domain-containing protein. (159 aa)
ENSNLEP00000036861Uncharacterized protein. (119 aa)
ENSNLEP00000036455Uncharacterized protein. (127 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
STX1BSyntaxin 1B; Belongs to the syntaxin family. (293 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (955 aa)
ENSNLEP00000034296DJ-1_PfpI domain-containing protein. (133 aa)
DNAJC5DnaJ heat shock protein family (Hsp40) member C5. (198 aa)
STX1At-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (243 aa)
LIN7CProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
SYNJ1Synaptojanin 1. (1383 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
ENSNLEP00000031088Protein kinase domain-containing protein. (557 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
ENSNLEP00000029188Uncharacterized protein. (60 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (251 aa)
PORCNPorcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (461 aa)
LIN7AProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (233 aa)
PPFIA3PTPRF interacting protein alpha 3. (1151 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
PRRT2Proline rich transmembrane protein 2. (349 aa)
LOC100581641Uncharacterized protein. (352 aa)
RESP18RESP18 domain-containing protein. (145 aa)
PDZD11PDZ domain containing 11. (140 aa)
ENSNLEP00000026359C2 domain-containing protein. (356 aa)
RAB11FIP2RAB11 family interacting protein 2. (532 aa)
SYN1Synapsin I. (639 aa)
PINK1Protein kinase domain-containing protein. (563 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
M3ZA63_NOMLESep15_SelM domain-containing protein. (153 aa)
SELENOTSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (194 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
MC4RMelanocortin 4 receptor. (332 aa)
GPR119G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (335 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (589 aa)
ADMAdrenomedullin. (184 aa)
SYT9Synaptotagmin 9. (472 aa)
TOR2ATorsin. (321 aa)
NIBAN2PH domain-containing protein. (700 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (379 aa)
ABCA1ATP binding cassette subfamily A member 1. (2254 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
NRXN3Uncharacterized protein. (1061 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (524 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
CCDC186Coiled-coil domain containing 186. (898 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (297 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
HRH3Histamine receptor H3; Belongs to the G-protein coupled receptor 1 family. (445 aa)
VIPVasoactive intestinal peptide. (170 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (424 aa)
STX11Syntaxin 11; Belongs to the syntaxin family. (287 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
SNAP47Synaptosome associated protein 47. (464 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1574 aa)
SYT8Synaptotagmin 8. (400 aa)
SLC16A10Solute carrier family 16 member 10. (515 aa)
FFAR4G_PROTEIN_RECEP_F1_2 domain-containing protein. (235 aa)
CYB5R4Cytochrome b5 reductase 4. (521 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
RIMS3Regulating synaptic membrane exocytosis 3. (308 aa)
PPT1Palmitoyl-protein thioesterase 1. (326 aa)
CADPS2Calcium dependent secretion activator 2. (1297 aa)
GATA3GATA binding protein 3. (444 aa)
WNK4WNK lysine deficient protein kinase 4. (1037 aa)
CADPSUncharacterized protein. (1183 aa)
UBE2Q1Ubiquitin conjugating enzyme E2 Q1. (422 aa)
TACR2Tachykinin receptor 2; Belongs to the G-protein coupled receptor 1 family. (393 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (462 aa)
SYT4Synaptotagmin 4. (425 aa)
RAB44RAB44, member RAS oncogene family. (929 aa)
ECRG4ECRG4 augurin precursor. (148 aa)
BRSK1UBA domain-containing protein. (449 aa)
RAB11FIP5RAB11 family interacting protein 5. (645 aa)
RAB1ARAB1A, member RAS oncogene family. (185 aa)
SV2ASynaptic vesicle glycoprotein 2A. (742 aa)
G1RE82_NOMLECollectrin domain-containing protein. (199 aa)
WLSWnt ligand secretion mediator. (542 aa)
GNRHRGonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (328 aa)
CPLX4Complexin 4. (160 aa)
STX2Syntaxin 2; Belongs to the syntaxin family. (287 aa)
DOC2ADouble C2 domain alpha. (355 aa)
BTKTyrosine-protein kinase. (659 aa)
SYTL4Synaptotagmin like 4. (672 aa)
SNX19Sorting nexin 19. (981 aa)
ERC2ELKS/RAB6-interacting/CAST family member 2. (957 aa)
NT5DC25'-nucleotidase domain containing 2. (558 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
LOC105738356Uncharacterized protein. (196 aa)
GALGalanin and GMAP prepropeptide. (123 aa)
NT5DC35'-nucleotidase domain containing 3. (548 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (639 aa)
SLC32A1Solute carrier family 32 member 1. (427 aa)
SYT12Synaptotagmin 12. (421 aa)
GHRHGrowth hormone releasing hormone. (108 aa)
RAB3ARAB3A, member RAS oncogene family. (186 aa)
BLOC1S6Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (176 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (925 aa)
NLGN1Neuroligin 1. (823 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SEPTIN5Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (323 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
NRXN2Neurexin 2. (1626 aa)
SYT1Synaptotagmin 1. (422 aa)
LIN7BProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (207 aa)
SYN3Synapsin III. (580 aa)
SYN2Uncharacterized protein. (506 aa)
CARTPTCART prepropeptide. (116 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
EXOC3L1Exocyst complex component 3 like 1. (740 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
RIMS2Uncharacterized protein. (1367 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (320 aa)
CDK16Cyclin dependent kinase 16; Belongs to the protein kinase superfamily. (493 aa)
INHBAInhibin subunit beta A. (426 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (765 aa)
OTOFOtoferlin. (1968 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (846 aa)
TMF1TATA element modulatory factor 1. (1096 aa)
SCRIBScribble planar cell polarity protein. (1449 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1860 aa)
IL1RNInterleukin-1. (159 aa)
RAB11BRAB11B, member RAS oncogene family. (218 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (26%) [HD]