STRINGSTRING
ZNF639 ZNF639 TRPV2 TRPV2 TRPC5 TRPC5 SEMA7A SEMA7A ACSL4 ACSL4 TGFB2 TGFB2 F2 F2 LOC100599068 LOC100599068 L1CAM L1CAM MTPN MTPN ADAM17 ADAM17 MAP2K5 MAP2K5 LGI1 LGI1 CRABP2 CRABP2 SFRP1 SFRP1 EXOSC2 EXOSC2 CIB1 CIB1 RND2 RND2 FGFR1OP FGFR1OP SEMA5A SEMA5A SUPV3L1 SUPV3L1 PRKN PRKN EFNA5 EFNA5 PARP2 PARP2 CPNE5 CPNE5 SYT4 SYT4 CDKN2AIP CDKN2AIP BRAT1 BRAT1 EXOSC4 EXOSC4 S100A9 S100A9 DISC1 DISC1 SPHK1 SPHK1 N6AMT1 N6AMT1 AKAP6 AKAP6 UCN UCN INO80 INO80 RIMS2 RIMS2 CPNE9 CPNE9 SRF SRF IGFBP1 IGFBP1 MAPT MAPT WNT3 WNT3 GOLGA4 GOLGA4 POU4F2 POU4F2 SYT3 SYT3 SFRP2 SFRP2 DDX49 DDX49 CACNG7 CACNG7 SLC44A4 SLC44A4 MAP3K13 MAP3K13 HYAL1 HYAL1 TWF2 TWF2 FN1 FN1 AVP AVP SLC23A2 SLC23A2 KLHL22 KLHL22 IL9 IL9 ADNP2 ADNP2 ARMC12 ARMC12 ANAPC2 ANAPC2 DERL2 DERL2 HBEGF HBEGF EXOSC9 EXOSC9 RPS6KA1 RPS6KA1 IL2 IL2 CSNK2A1 CSNK2A1 SLC9A1 SLC9A1 CDKL5 CDKL5 RPS6KA3 RPS6KA3 LPAR3 LPAR3 RASAL1 RASAL1 SEMA4D SEMA4D TAF9B TAF9B DNPH1 DNPH1 CRK CRK EDN1 EDN1 ITSN2 ITSN2 LOC100595279 LOC100595279 ERBB2 ERBB2 ENSNLEP00000048874 ENSNLEP00000048874 SMAD7 SMAD7 SMURF1 SMURF1 LOC100593825 LOC100593825 ENSNLEP00000047852 ENSNLEP00000047852 SYT2 SYT2 S100A8 S100A8 DBN1 DBN1 NRG1 NRG1 KDM2B KDM2B UNC13A UNC13A SYT17 SYT17 IGF1 IGF1 SLC25A33 SLC25A33 DBNL DBNL ENSNLEP00000042367 ENSNLEP00000042367 LOC100591180 LOC100591180 BMPR2 BMPR2 TGFBR1 TGFBR1 BCL11A BCL11A MACF1 MACF1 LOC100583243 LOC100583243 CDC42 CDC42 RUFY3 RUFY3 DSCAM DSCAM RIMS1 RIMS1 CXCL12 CXCL12 MAP1B MAP1B ENSNLEP00000038401 ENSNLEP00000038401 ENSNLEP00000037793 ENSNLEP00000037793 MLST8 MLST8 BCL2 BCL2 LIMK1 LIMK1 EIF4G1 EIF4G1 EGFR EGFR TRIM32 TRIM32 SDCBP SDCBP CXCL16 CXCL16 ENSNLEP00000034023 ENSNLEP00000034023 MTOR MTOR ENSNLEP00000032543 ENSNLEP00000032543 ENSNLEP00000032181 ENSNLEP00000032181 NCBP1 NCBP1 HPN HPN YAP1 YAP1 PSMD10 PSMD10 LOC100592963 LOC100592963 RPTOR RPTOR ENSNLEP00000029912 ENSNLEP00000029912 CYFIP1 CYFIP1 NGF NGF FXN FXN MUL1 MUL1 LOC100584404 LOC100584404 DDX3X DDX3X AKT1 AKT1 CD38 CD38 ZFYVE27 ZFYVE27 FAM122A FAM122A ENSNLEP00000026915 ENSNLEP00000026915 ENSNLEP00000026316 ENSNLEP00000026316 WNT3A WNT3A ADAM10 ADAM10 RNF157 RNF157 ENSNLEP00000024692 ENSNLEP00000024692 NRP1 NRP1 USP47 USP47 MEGF8 MEGF8 ADNP ADNP COMMD5 COMMD5 H1-5 H1-5 SFN SFN BDNF BDNF TEAD1 TEAD1 AVPR1A AVPR1A EXTL3 EXTL3 SHTN1 SHTN1 RICTOR RICTOR PLAA PLAA PTK2B PTK2B CDH4 CDH4 NOL12 NOL12 MMP14 MMP14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZNF639Zinc finger protein 639. (485 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (764 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (613 aa)
LOC100599068Histone H3; Belongs to the histone H3 family. (136 aa)
L1CAML1 cell adhesion molecule. (1174 aa)
MTPNMyotrophin. (118 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (414 aa)
LGI1Leucine rich glioma inactivated 1. (557 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
EXOSC2Exosome component 2. (293 aa)
CIB1Uncharacterized protein. (187 aa)
RND2Rho family GTPase 2. (227 aa)
FGFR1OPFGFR1 oncogene partner. (399 aa)
SEMA5ASemaphorin 5A. (1074 aa)
SUPV3L1Suv3 like RNA helicase. (779 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (437 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
PARP2Poly [ADP-ribose] polymerase. (583 aa)
CPNE5Copine 5. (579 aa)
SYT4Synaptotagmin 4. (425 aa)
CDKN2AIPCDKN2A interacting protein. (580 aa)
BRAT1BRCA1 associated ATM activator 1. (821 aa)
EXOSC4Exosome component 4. (245 aa)
S100A9Protein S100; Belongs to the S-100 family. (112 aa)
DISC1Uncharacterized protein. (202 aa)
SPHK1DAGKc domain-containing protein. (398 aa)
N6AMT1N-6 adenine-specific DNA methyltransferase 1. (214 aa)
AKAP6A-kinase anchoring protein 6. (2238 aa)
UCNUrocortin. (124 aa)
INO80INO80 complex ATPase subunit. (1538 aa)
RIMS2Uncharacterized protein. (1367 aa)
CPNE9Copine family member 9. (547 aa)
SRFSerum response factor. (508 aa)
IGFBP1Insulin like growth factor binding protein 1. (281 aa)
MAPTMicrotubule-associated protein. (732 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
GOLGA4Golgin A4. (2155 aa)
POU4F2POU domain protein. (408 aa)
SYT3Synaptotagmin 3. (584 aa)
SFRP2Secreted frizzled related protein 2. (280 aa)
DDX49DEAD-box helicase 49; Belongs to the DEAD box helicase family. (483 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (271 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (639 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
HYAL1Hyaluronidase. (435 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
FN1Fibronectin 1. (2477 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
SLC23A2Solute carrier family 23 member 2. (649 aa)
KLHL22Kelch like family member 22. (558 aa)
IL9Interleukin 9. (144 aa)
ADNP2ADNP homeobox 2. (1125 aa)
ARMC12Armadillo repeat containing 12. (367 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (808 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
EXOSC9Exosome component 9. (456 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (809 aa)
CDKL5Cyclin dependent kinase like 5. (994 aa)
RPS6KA3Ribosomal protein S6 kinase. (732 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (342 aa)
RASAL1RAS protein activator like 1. (776 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
TAF9BTATA-box binding protein associated factor 9b. (250 aa)
DNPH1Uncharacterized protein. (121 aa)
CRKUncharacterized protein. (252 aa)
EDN1Endothelin 1. (211 aa)
ITSN2Intersectin 2. (1643 aa)
LOC100595279Uncharacterized protein. (212 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
ENSNLEP00000048874Uncharacterized protein. (178 aa)
SMAD7Mothers against decapentaplegic homolog. (376 aa)
SMURF1E3 ubiquitin-protein ligase. (749 aa)
LOC100593825Histone H3; Belongs to the histone H3 family. (136 aa)
ENSNLEP00000047852Laminin N-terminal domain-containing protein. (447 aa)
SYT2Synaptotagmin 2. (419 aa)
S100A8Protein S100; Belongs to the S-100 family. (93 aa)
DBN1Drebrin 1. (636 aa)
NRG1Neuregulin 1. (713 aa)
KDM2BLysine demethylase 2B. (1290 aa)
UNC13AUnc-13 homolog A. (1460 aa)
SYT17Synaptotagmin 17. (474 aa)
IGF1IlGF domain-containing protein. (196 aa)
SLC25A33Solute carrier family 25 member 33; Belongs to the mitochondrial carrier (TC 2.A.29) family. (324 aa)
DBNLDrebrin like. (439 aa)
ENSNLEP00000042367PDZ_6 domain-containing protein. (254 aa)
LOC100591180Histone domain-containing protein. (136 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (838 aa)
MACF1Uncharacterized protein. (7315 aa)
LOC100583243Histone H3; Belongs to the histone H3 family. (136 aa)
CDC42Cell division cycle 42. (191 aa)
RUFY3RUN and FYVE domain containing 3. (594 aa)
DSCAMDS cell adhesion molecule. (1827 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1637 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
MAP1BMicrotubule associated protein 1B. (2370 aa)
ENSNLEP00000038401ANK_REP_REGION domain-containing protein. (141 aa)
ENSNLEP00000037793Uncharacterized protein. (122 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
LIMK1Uncharacterized protein. (614 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1558 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
TRIM32Tripartite motif containing 32. (653 aa)
SDCBPSyndecan binding protein. (318 aa)
CXCL16C-X-C motif chemokine ligand 16. (265 aa)
ENSNLEP00000034023Histone H3; Belongs to the histone H3 family. (129 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
ENSNLEP00000032543Uncharacterized protein. (168 aa)
ENSNLEP00000032181Uncharacterized protein. (103 aa)
NCBP1Nuclear cap binding protein subunit 1. (790 aa)
HPNHepsin; Belongs to the peptidase S1 family. (431 aa)
YAP1Uncharacterized protein. (418 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
LOC100592963annotation not available (136 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1318 aa)
ENSNLEP00000029912Uncharacterized protein. (121 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1228 aa)
NGFNGF domain-containing protein; Belongs to the NGF-beta family. (123 aa)
FXNUncharacterized protein. (196 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (338 aa)
LOC100584404Uncharacterized protein. (253 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (704 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
CD38CD38 molecule. (300 aa)
ZFYVE27Zinc finger FYVE-type containing 27. (416 aa)
FAM122AFamily with sequence similarity 122A. (329 aa)
ENSNLEP00000026915annotation not available (136 aa)
ENSNLEP00000026316Uncharacterized protein. (233 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
RNF157Ring finger protein 157. (678 aa)
ENSNLEP00000024692Uncharacterized protein. (267 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
MEGF8Multiple EGF like domains 8. (2574 aa)
ADNPActivity dependent neuroprotector homeobox. (1102 aa)
COMMD5COMM domain containing 5. (224 aa)
H1-5Histone cluster 1 H1 family member b. (226 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
TEAD1TEA domain transcription factor 1. (426 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. (405 aa)
EXTL3Exostosin like glycosyltransferase 3; Belongs to the glycosyltransferase 47 family. (919 aa)
SHTN1Shootin 1. (631 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1709 aa)
PLAAPhospholipase A2 activating protein. (764 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
CDH4Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins. (893 aa)
NOL12Uncharacterized protein. (182 aa)
MMP14Matrix metallopeptidase 14. (586 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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