node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS20 | TYRP1 | ENSNLEP00000032948 | ENSNLEP00000021434 | ADAM metallopeptidase with thrombospondin type 1 motif 20. | Tyrosinase related protein 1. | 0.461 |
BCL2 | KIT | ENSNLEP00000036597 | ENSNLEP00000010174 | BCL2 apoptosis regulator. | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.497 |
BCL2 | MITF | ENSNLEP00000036597 | ENSNLEP00000047730 | BCL2 apoptosis regulator. | Melanocyte inducing transcription factor. | 0.472 |
BLOC1S6 | HPS4 | ENSNLEP00000007128 | ENSNLEP00000009402 | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] | HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. | 0.434 |
BLOC1S6 | HPS6 | ENSNLEP00000007128 | ENSNLEP00000022962 | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] | Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. | 0.835 |
EDN3 | EDNRB | ENSNLEP00000041802 | ENSNLEP00000019898 | Uncharacterized protein. | Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. | 0.999 |
EDN3 | MITF | ENSNLEP00000041802 | ENSNLEP00000047730 | Uncharacterized protein. | Melanocyte inducing transcription factor. | 0.456 |
EDN3 | SOX10 | ENSNLEP00000041802 | ENSNLEP00000024850 | Uncharacterized protein. | HMG box domain-containing protein. | 0.676 |
EDNRB | EDN3 | ENSNLEP00000019898 | ENSNLEP00000041802 | Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. | Uncharacterized protein. | 0.999 |
EDNRB | KIT | ENSNLEP00000019898 | ENSNLEP00000010174 | Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.467 |
EDNRB | MITF | ENSNLEP00000019898 | ENSNLEP00000047730 | Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. | Melanocyte inducing transcription factor. | 0.472 |
EDNRB | SOX10 | ENSNLEP00000019898 | ENSNLEP00000024850 | Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. | HMG box domain-containing protein. | 0.692 |
GLI3 | SOX10 | ENSNLEP00000003829 | ENSNLEP00000024850 | GLI family zinc finger 3. | HMG box domain-containing protein. | 0.422 |
HPS4 | BLOC1S6 | ENSNLEP00000009402 | ENSNLEP00000007128 | HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] | 0.434 |
HPS4 | HPS6 | ENSNLEP00000009402 | ENSNLEP00000022962 | HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. | Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. | 0.556 |
HPS6 | BLOC1S6 | ENSNLEP00000022962 | ENSNLEP00000007128 | Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] | 0.835 |
HPS6 | HPS4 | ENSNLEP00000022962 | ENSNLEP00000009402 | Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. | HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. | 0.556 |
HPS6 | LRMDA | ENSNLEP00000022962 | ENSNLEP00000024869 | Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. | Leucine rich melanocyte differentiation associated. | 0.457 |
HPS6 | OCA2 | ENSNLEP00000022962 | ENSNLEP00000028600 | Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. | OCA2 melanosomal transmembrane protein. | 0.446 |
HPS6 | SLC24A5 | ENSNLEP00000022962 | ENSNLEP00000007193 | Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. | Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.446 |