STRINGSTRING
FGFR2 FGFR2 WNT11 WNT11 PKDCC PKDCC SEC24B SEC24B TGFB3 TGFB3 AGR2 AGR2 HIKESHI HIKESHI NODAL NODAL HS6ST1 HS6ST1 CELSR1 CELSR1 CCDC40 CCDC40 FGF8 FGF8 MMP14 MMP14 CYP1A2 CYP1A2 CCN2 CCN2 PROX1 PROX1 ARG1 ARG1 SLC7A11 SLC7A11 EIF4E EIF4E TGFB1 TGFB1 WNT7B WNT7B FGF9 FGF9 AP3B1 AP3B1 BMP4 BMP4 EDN2 EDN2 LOX LOX WNT2 WNT2 FOXF1 FOXF1 STK40 STK40 MAN2A1 MAN2A1 CRISPLD2 CRISPLD2 ALDH1A2 ALDH1A2 TTC25 TTC25 G1RJG4_NOMLE G1RJG4_NOMLE SFTPD SFTPD DLG5 DLG5 PDGFRB PDGFRB PHEX PHEX PDPN PDPN ASXL1 ASXL1 RBBP9 RBBP9 FGF1 FGF1 DSPP DSPP CTSZ CTSZ SLC23A1 SLC23A1 LHX3 LHX3 ITGA3 ITGA3 ERRFI1 ERRFI1 CTSH CTSH CCBE1 CCBE1 SPDEF SPDEF NOTCH1 NOTCH1 PDGFA PDGFA PLOD3 PLOD3 LOC100589493 LOC100589493 IGFBP5 IGFBP5 WNT5A WNT5A ABCA12 ABCA12 MMP12 MMP12 PGR PGR CREB1 CREB1 LAMA1 LAMA1 DAG1 DAG1 GATA6 GATA6 COL3A1 COL3A1 PPP1CA PPP1CA BAG6 BAG6 FGF7 FGF7 RAB3A RAB3A CCDC39 CCDC39 LTA4H LTA4H FBXW7 FBXW7 CTNNB1 CTNNB1 LTBP3 LTBP3 FNDC3B FNDC3B KLF2 KLF2 HHIP HHIP ACVR2B ACVR2B SMPD3 SMPD3 MAN1A2 MAN1A2 KRAS KRAS RCN3 RCN3 ESRP2 ESRP2 G1QYG1_NOMLE G1QYG1_NOMLE EXT1 EXT1 SIM2 SIM2 PTK7 PTK7 SRF SRF TGFBR2 TGFBR2 DPPA4 DPPA4 NOS3 NOS3 ZFPM2 ZFPM2 NKX2-1 NKX2-1 NKX2-8 NKX2-8 LIF LIF ELK1 ELK1 GRHL2 GRHL2 GLI3 GLI3 MAP2K2 MAP2K2 ZIC3 ZIC3 FLT4 FLT4 MAPK3 MAPK3 HSD11B1 HSD11B1 ADAMTS2 ADAMTS2 ATP7A ATP7A GLI2 GLI2 TBX4 TBX4 TBX2 TBX2 G1QHL5_NOMLE G1QHL5_NOMLE NFIB NFIB TBX5 TBX5 ENSNLEP00000032236 ENSNLEP00000032236 YAP1 YAP1 ADA ADA CRH CRH SREBF1 SREBF1 STRA6 STRA6 FGF10 FGF10 SPRY2 SPRY2 RSPO2 RSPO2 PTGES3 PTGES3 SP3 SP3 HMGCS2 HMGCS2 MYOCD MYOCD HOPX HOPX RDH10 RDH10 KDR KDR CLCN2 CLCN2 NKIRAS2 NKIRAS2 ENSNLEP00000042936 ENSNLEP00000042936 NOG NOG LAMA5 LAMA5 BMPR2 BMPR2 ENSNLEP00000041450 ENSNLEP00000041450 FOXA1 FOXA1 JMJD6 JMJD6 AIMP2 AIMP2 ABCA3 ABCA3 AARD AARD NKIRAS1 NKIRAS1 SAV1 SAV1 FGF2 FGF2 PKD1 PKD1 EP300 EP300 EIF4G1 EIF4G1 LIPA LIPA ENSNLEP00000033486 ENSNLEP00000033486 RIDA RIDA ENSNLEP00000032543 ENSNLEP00000032543 TCF21 TCF21 ASCL1 ASCL1 MAPK1 MAPK1 SOX9 SOX9 SPRY1 SPRY1 HSPB11 HSPB11 PPP3R1 PPP3R1 FBXW9 FBXW9 ITGB6 ITGB6 ENSNLEP00000025665 ENSNLEP00000025665 LOXL3 LOXL3 BMPR1A BMPR1A THRB THRB PHF14 PHF14 HEG1 HEG1 SMAD2 SMAD2 ATXN1L ATXN1L CHI3L1 CHI3L1 TIMELESS TIMELESS GLI1 GLI1 TMEM38B TMEM38B NUMA1 NUMA1 RC3H2 RC3H2 EPAS1 EPAS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGFR2Fibroblast growth factor receptor. (820 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1236 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (189 aa)
HIKESHIHeat shock protein nuclear import factor hikeshi. (197 aa)
NODALNodal growth differentiation factor. (347 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (411 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2918 aa)
CCDC40Coiled-coil domain containing 40. (1137 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
MMP14Matrix metallopeptidase 14. (586 aa)
CYP1A2Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa)
CCN2Cellular communication network factor 2. (349 aa)
PROX1Prospero homeobox 1. (737 aa)
ARG1Arginase. (322 aa)
SLC7A11Solute carrier family 7 member 11. (500 aa)
EIF4EUncharacterized protein. (212 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1045 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
EDN2Endothelin 2. (177 aa)
LOXLysyl oxidase. (417 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
FOXF1Uncharacterized protein. (361 aa)
STK40Serine/threonine kinase 40. (440 aa)
MAN2A1Alpha-mannosidase. (1128 aa)
CRISPLD2Cysteine rich secretory protein LCCL domain containing 2. (497 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
TTC25Tetratricopeptide repeat domain 25. (576 aa)
G1RJG4_NOMLEDynein assembly factor 1, axonemal. (655 aa)
SFTPDSurfactant protein D. (375 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1889 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
PHEXPhosphate regulating endopeptidase homolog X-linked. (752 aa)
PDPNUncharacterized protein. (175 aa)
ASXL1ASXL transcriptional regulator 1. (1536 aa)
RBBP9RB binding protein 9, serine hydrolase. (186 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
DSPPUncharacterized protein. (1265 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
SLC23A1Solute carrier family 23 member 1. (545 aa)
LHX3Uncharacterized protein. (367 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1050 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
NOTCH1Notch receptor 1. (2451 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PLOD3Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (628 aa)
LOC100589493PLAC domain-containing protein. (130 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ABCA12ATP binding cassette subfamily A member 12. (2550 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
PGRUncharacterized protein. (339 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
LAMA1Laminin subunit alpha 1. (3033 aa)
DAG1Dystroglycan 1. (895 aa)
GATA6Uncharacterized protein. (452 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
BAG6BCL2 associated athanogene 6. (1119 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
RAB3ARAB3A, member RAS oncogene family. (186 aa)
CCDC39Coiled-coil domain containing 39. (942 aa)
LTA4HLeukotriene A4 hydrolase. (576 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
CTNNB1Catenin beta 1. (781 aa)
LTBP3Uncharacterized protein. (1148 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
KLF2Kruppel like factor 2. (355 aa)
HHIPHedgehog interacting protein. (700 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
MAN1A2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (634 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RCN3Reticulocalbin 3. (319 aa)
ESRP2Epithelial splicing regulatory protein 2. (717 aa)
G1QYG1_NOMLEProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (323 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (745 aa)
SIM2Uncharacterized protein. (545 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
SRFSerum response factor. (508 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
DPPA4Developmental pluripotency associated 4. (304 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1151 aa)
NKX2-1NK2 homeobox 1. (394 aa)
NKX2-8NK2 homeobox 8. (229 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
ELK1ETS transcription factor ELK1. (390 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
GLI3GLI family zinc finger 3. (1502 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (383 aa)
ZIC3Uncharacterized protein. (360 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
MAPK3Mitogen-activated protein kinase. (278 aa)
HSD11B1Hydroxysteroid 11-beta dehydrogenase 1. (291 aa)
ADAMTS2Uncharacterized protein. (1056 aa)
ATP7AATPase copper transporting alpha. (1460 aa)
GLI2GLI family zinc finger 2. (1589 aa)
TBX4T-box transcription factor 4. (547 aa)
TBX2T-box transcription factor 2. (647 aa)
G1QHL5_NOMLEUncharacterized protein; Belongs to the heparin-binding growth factors family. (182 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (487 aa)
TBX5T-box transcription factor 5. (508 aa)
ENSNLEP00000032236Uncharacterized protein. (109 aa)
YAP1Uncharacterized protein. (418 aa)
ADAAdenosine deaminase. (405 aa)
CRHCorticotropin releasing hormone. (196 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
STRA6Stimulated by retinoic acid 6. (636 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
RSPO2R-spondin 2. (250 aa)
PTGES3Prostaglandin E synthase 3. (164 aa)
SP3Sp3 transcription factor. (744 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
MYOCDMyocardin. (986 aa)
HOPXUncharacterized protein. (91 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
CLCN2Chloride channel protein. (898 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (231 aa)
ENSNLEP00000042936Protein kinase domain-containing protein. (201 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
LAMA5Laminin subunit alpha 5. (3418 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
ENSNLEP00000041450DUF775 domain-containing protein. (110 aa)
FOXA1Uncharacterized protein. (346 aa)
JMJD6JmjC domain-containing protein. (249 aa)
AIMP2Aminoacyl tRNA synthetase complex interacting multifunctional protein 2. (320 aa)
ABCA3ATP binding cassette subfamily A member 3. (1719 aa)
AARDAlanine and arginine rich domain containing protein. (154 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
PKD1Uncharacterized protein. (270 aa)
EP300E1A binding protein p300. (2306 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1558 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
ENSNLEP00000033486Uncharacterized protein. (126 aa)
RIDAReactive intermediate imine deaminase A homolog. (137 aa)
ENSNLEP00000032543Uncharacterized protein. (168 aa)
TCF21Transcription factor 21. (179 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (235 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
SOX9SRY-box transcription factor 9. (510 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
HSPB11Uncharacterized protein. (214 aa)
PPP3R1Uncharacterized protein. (189 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
ENSNLEP00000025665Uncharacterized protein. (686 aa)
LOXL3Lysyl oxidase like 3. (753 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
THRBUncharacterized protein. (476 aa)
PHF14PHD finger protein 14. (946 aa)
HEG1Heart development protein with EGF like domains 1. (1194 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ATXN1LAtaxin 1 like. (689 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (403 aa)
TIMELESSTimeless circadian regulator. (1176 aa)
GLI1GLI family zinc finger 1. (1106 aa)
TMEM38BTransmembrane protein 38B. (291 aa)
NUMA1Uncharacterized protein. (947 aa)
RC3H2Ring finger and CCCH-type domains 2. (1180 aa)
EPAS1Endothelial PAS domain protein 1. (869 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (18%) [HD]