STRINGSTRING
ACTN2 ACTN2 ELK1 ELK1 MED4 MED4 CNOT6 CNOT6 CCDC62 CCDC62 TMF1 TMF1 MED14 MED14 ENSNLEP00000038405 ENSNLEP00000038405 RNF4 RNF4 MED24 MED24 MED1 MED1 USP22 USP22 SFR1 SFR1 NCOA1 NCOA1 ACTN1 ACTN1 ENY2-3 ENY2-3 CARM1 CARM1 NCOA7 NCOA7 PPRC1 PPRC1 CALCOCO1 CALCOCO1 TSG101 TSG101 CCAR1 CCAR1 LOC100580143 LOC100580143 HMGA1 HMGA1 ETS1 ETS1 PKN1 PKN1 ENSNLEP00000026167 ENSNLEP00000026167 LOC100607254 LOC100607254 KDM1A KDM1A SS18 SS18 CNOT9 CNOT9 BRD8 BRD8 ACTN4 ACTN4 NCOA3 NCOA3 TRERF1 TRERF1 SMARCD3 SMARCD3 ATXN7L3 ATXN7L3 MED30 MED30 G1RA54_NOMLE G1RA54_NOMLE HELZ2 HELZ2 PPARGC1B PPARGC1B ZMIZ1 ZMIZ1 BUD31 BUD31 NCOA2 NCOA2 THRAP3 THRAP3 PSMC3IP PSMC3IP TACC1 TACC1 ENY2-2 ENY2-2 ENY2 ENY2 TADA3 TADA3 DCAF6 DCAF6 LOC105738951 LOC105738951 PRKCB PRKCB ENSNLEP00000042529 ENSNLEP00000042529 PPARGC1A PPARGC1A MED13 MED13 SRA1 SRA1 LOC100583834 LOC100583834 ZMIZ2 ZMIZ2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTN2Actinin alpha 2. (854 aa)
ELK1ETS transcription factor ELK1. (390 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (270 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (552 aa)
CCDC62Coiled-coil domain containing 62. (684 aa)
TMF1TATA element modulatory factor 1. (1096 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1454 aa)
ENSNLEP00000038405AAA_11 domain-containing protein. (641 aa)
RNF4Ring finger protein 4. (190 aa)
MED24Mediator complex subunit 24. (1003 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1558 aa)
USP22Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (504 aa)
SFR1SWI5 dependent homologous recombination repair protein 1. (245 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
ACTN1Actinin alpha 1. (921 aa)
ENY2-3Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] (103 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (563 aa)
NCOA7Nuclear receptor coactivator 7. (942 aa)
PPRC1PPARG related coactivator 1. (1664 aa)
CALCOCO1Calcium binding and coiled-coil domain 1. (675 aa)
TSG101Tumor susceptibility 101. (390 aa)
CCAR1Cell division cycle and apoptosis regulator 1. (1150 aa)
LOC100580143RING-type domain-containing protein. (193 aa)
HMGA1High mobility group AT-hook 1. (90 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
PKN1Protein kinase domain-containing protein. (839 aa)
ENSNLEP00000026167EF-hand domain-containing protein. (463 aa)
LOC100607254RING-type domain-containing protein. (317 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (759 aa)
SS18SS18 subunit of BAF chromatin remodeling complex. (418 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (331 aa)
BRD8Bromodomain containing 8. (1234 aa)
ACTN4Actinin alpha 4. (931 aa)
NCOA3Nuclear receptor coactivator. (1419 aa)
TRERF1Transcriptional regulating factor 1. (1218 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (478 aa)
ATXN7L3Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] (335 aa)
MED30Mediator complex subunit 30. (178 aa)
G1RA54_NOMLEUncharacterized protein. (183 aa)
HELZ2RNB domain-containing protein. (2612 aa)
PPARGC1BPPARG coactivator 1 beta. (1013 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1067 aa)
BUD31BUD31 homolog. (139 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
THRAP3Thyroid hormone receptor associated protein 3. (954 aa)
PSMC3IPUncharacterized protein. (258 aa)
TACC1Transforming acidic coiled-coil containing protein 1. (806 aa)
ENY2-2Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] (102 aa)
ENY2Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] (101 aa)
TADA3Transcriptional adaptor 3. (440 aa)
DCAF6Uncharacterized protein. (948 aa)
LOC105738951Uncharacterized protein. (177 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ENSNLEP00000042529CARM1 domain-containing protein. (165 aa)
PPARGC1APPARG coactivator 1 alpha. (801 aa)
MED13Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2166 aa)
SRA1Steroid receptor RNA activator 1. (236 aa)
LOC100583834Uncharacterized protein. (106 aa)
ZMIZ2Zinc finger MIZ-type containing 2. (857 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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