STRINGSTRING
GLG1 GLG1 WFIKKN2 WFIKKN2 LOC100589493 LOC100589493 BCL9L BCL9L SLC2A10 SLC2A10 SPINT3 SPINT3 ONECUT1 ONECUT1 FAM89B FAM89B VEPH1 VEPH1 NKX2-1 NKX2-1 LEMD3 LEMD3 ZNF451 ZNF451 ARID4B ARID4B EMILIN1 EMILIN1 NRROS NRROS FBN2 FBN2 HDAC2 HDAC2 ENSNLEP00000038312 ENSNLEP00000038312 ENSNLEP00000037210 ENSNLEP00000037210 PPARG PPARG ENSNLEP00000035561 ENSNLEP00000035561 SAP30 SAP30 ENSNLEP00000033486 ENSNLEP00000033486 IL17RD IL17RD CAV1 CAV1 LINGO3 LINGO3 ENSNLEP00000032148 ENSNLEP00000032148 CD109 CD109 ENSNLEP00000031295 ENSNLEP00000031295 DNM2 DNM2 ENSNLEP00000028374 ENSNLEP00000028374 SPRY2 SPRY2 SPRED1 SPRED1 ENSNLEP00000027025 ENSNLEP00000027025 SPRY1 SPRY1 ENG ENG BRMS1 BRMS1 LDLRAD4 LDLRAD4 CHST11 CHST11 WNT1 WNT1 ING1 ING1 SKOR2 SKOR2 SMAD6 SMAD6 SMAD7 SMAD7 ENSNLEP00000048301 ENSNLEP00000048301 SMURF1 SMURF1 HTRA4 HTRA4 OGT OGT FBN1 FBN1 ENSNLEP00000044642 ENSNLEP00000044642 SKIL SKIL PMEPA1 PMEPA1 ENSNLEP00000044100 ENSNLEP00000044100 SIN3A SIN3A BRMS1L BRMS1L XBP1 XBP1 HTRA1 HTRA1 LOC100593010 LOC100593010 STRAP STRAP SPRED2 SPRED2 LOC100582696 LOC100582696 HSPA5 HSPA5 BAMBI BAMBI SPRED3 SPRED3 TGFB3 TGFB3 SAP30L SAP30L ASPN ASPN TGFB1I1 TGFB1I1 LTBP1 LTBP1 SAP130 SAP130 PPARA PPARA SMURF2 SMURF2 BMP2 BMP2 PPM1A PPM1A ADAM17 ADAM17 DAND5 DAND5 SIRT1 SIRT1 PIN1 PIN1 HTRA3 HTRA3 PBLD PBLD TET1 TET1 CAV2 CAV2 SNX25 SNX25 TGFBR3 TGFBR3 LOC100592336 LOC100592336 CIDEA CIDEA MTMR4 MTMR4 STUB1 STUB1 RASL11B RASL11B PRDM16 PRDM16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GLG1Golgi glycoprotein 1. (1104 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (577 aa)
LOC100589493PLAC domain-containing protein. (130 aa)
BCL9LBCL9 like. (1338 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (541 aa)
SPINT3Serine peptidase inhibitor, Kunitz type 3. (89 aa)
ONECUT1One cut domain family member. (465 aa)
FAM89BUncharacterized protein. (115 aa)
VEPH1Ventricular zone expressed PH domain containing 1. (833 aa)
NKX2-1NK2 homeobox 1. (394 aa)
LEMD3MSC domain-containing protein. (437 aa)
ZNF451Zinc finger protein 451. (1061 aa)
ARID4BAT-rich interaction domain 4B. (1314 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
NRROSNegative regulator of reactive oxygen species. (674 aa)
FBN2Fibrillin 2. (2858 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (533 aa)
ENSNLEP00000038312Uncharacterized protein; Belongs to the heat shock protein 70 family. (615 aa)
ENSNLEP00000037210PHD domain-containing protein. (253 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
ENSNLEP00000035561Uncharacterized protein. (155 aa)
SAP30Sin3A associated protein 30. (220 aa)
ENSNLEP00000033486Uncharacterized protein. (126 aa)
IL17RDInterleukin 17 receptor D. (728 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
LINGO3Leucine rich repeat and Ig domain containing 3. (588 aa)
ENSNLEP00000032148LRRNT domain-containing protein. (382 aa)
CD109CD109 molecule. (1405 aa)
ENSNLEP00000031295WD_REPEATS_REGION domain-containing protein. (301 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (770 aa)
ENSNLEP00000028374PHD domain-containing protein. (263 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
SPRED1Sprouty related EVH1 domain containing 1. (444 aa)
ENSNLEP00000027025PPM-type phosphatase domain-containing protein. (340 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
ENGEndoglin. (658 aa)
BRMS1BRMS1 transcriptional repressor and anoikis regulator. (290 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
ING1Inhibitor of growth protein. (279 aa)
SKOR2c-SKI_SMAD_bind domain-containing protein. (295 aa)
SMAD6Mothers against decapentaplegic homolog. (465 aa)
SMAD7Mothers against decapentaplegic homolog. (376 aa)
ENSNLEP00000048301Peptidyl-prolyl cis-trans isomerase. (144 aa)
SMURF1E3 ubiquitin-protein ligase. (749 aa)
HTRA4HtrA serine peptidase 4. (476 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1024 aa)
FBN1Fibrillin 1. (2873 aa)
ENSNLEP00000044642Uncharacterized protein. (411 aa)
SKILSKI like proto-oncogene. (683 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (274 aa)
ENSNLEP00000044100Inhibitor of growth protein. (229 aa)
SIN3ASIN3 transcription regulator family member A. (1250 aa)
BRMS1LBRMS1 like transcriptional repressor. (275 aa)
XBP1BZIP domain-containing protein. (376 aa)
HTRA1HtrA serine peptidase 1. (460 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
STRAPSerine/threonine kinase receptor associated protein. (364 aa)
SPRED2Sprouty related EVH1 domain containing 2. (418 aa)
LOC100582696Uncharacterized protein. (329 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (247 aa)
SPRED3Uncharacterized protein. (438 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SAP30LSAP30 like. (183 aa)
ASPNAsporin. (376 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (460 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1698 aa)
SAP130Sin3A associated protein 130. (1083 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
SMURF2E3 ubiquitin-protein ligase. (745 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
DAND5DAN domain BMP antagonist family member 5. (189 aa)
SIRT1Sirtuin 1. (734 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
HTRA3HtrA serine peptidase 3. (418 aa)
PBLDPhenazine biosynthesis like protein domain containing. (288 aa)
TET1Tet methylcytosine dioxygenase 1. (2136 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (86 aa)
SNX25Sorting nexin 25. (757 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
CIDEACell death inducing DFFA like effector a. (219 aa)
MTMR4Myotubularin related protein 4. (1163 aa)
STUB1Uncharacterized protein. (231 aa)
RASL11BRAS like family 11 member B. (248 aa)
PRDM16PR/SET domain 16. (1213 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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