STRINGSTRING
FST FST MED1 MED1 ZFP36L1 ZFP36L1 REG3G REG3G REG3A REG3A FOXJ2 FOXJ2 IL1A IL1A OSR1 OSR1 FOXN1 FOXN1 LHX1 LHX1 NFE2L1 NFE2L1 WWTR1 WWTR1 GRHL2 GRHL2 ESRP1 ESRP1 LIF LIF APOLD1 APOLD1 CDH5 CDH5 SULT2B1 SULT2B1 WNT9B WNT9B AQP3 AQP3 KRAS KRAS GDF3 GDF3 ETV4 ETV4 CTNNB1 CTNNB1 FRZB FRZB SRSF6 SRSF6 NOTCH4 NOTCH4 MMP9 MMP9 NCOA3 NCOA3 BMP7 BMP7 ABCA12 ABCA12 MAFG MAFG G1R9J5_NOMLE G1R9J5_NOMLE AJAP1 AJAP1 SERPINE1 SERPINE1 NOTCH1 NOTCH1 S1PR3 S1PR3 ERRFI1 ERRFI1 NKX6-1 NKX6-1 DSPP DSPP ID1 ID1 NKX2-2 NKX2-2 KRT36 KRT36 CEACAM1 CEACAM1 MACROH2A2 MACROH2A2 STAT5B STAT5B BMP6 BMP6 MESP1 MESP1 GATA3 GATA3 MYCL MYCL KEAP1 KEAP1 PAX4 PAX4 SMO SMO BMP4 BMP4 IKBKB IKBKB HEY2 HEY2 BMP2 BMP2 PTCH2 PTCH2 PLCB1 PLCB1 ZFP36 ZFP36 JAG1 JAG1 TRIM16 TRIM16 AHI1 AHI1 PAX2 PAX2 MAFF MAFF GDF2 GDF2 NODAL NODAL PROM1 PROM1 PTCH1 PTCH1 SIX2 SIX2 SPRED3 SPRED3 CYP27B1 CYP27B1 NUMA1 NUMA1 ZDHHC21 ZDHHC21 KRT84 KRT84 ACVRL1 ACVRL1 VDR VDR ZEB1 ZEB1 SFN SFN ATOH1 ATOH1 G1SB75_NOMLE G1SB75_NOMLE COMMD5 COMMD5 F11R F11R CDKN1B CDKN1B SPRY1 SPRY1 SOX9 SOX9 ENSNLEP00000027393 ENSNLEP00000027393 ASCL1 ASCL1 SPRED1 SPRED1 SPRY2 SPRY2 ENSNLEP00000028086 ENSNLEP00000028086 DLL1 DLL1 GDNF GDNF EZH2 EZH2 FGF10 FGF10 TNFRSF1A TNFRSF1A VEZF1 VEZF1 ADD1 ADD1 MACROH2A1 MACROH2A1 CD109 CD109 YAP1 YAP1 CCND1 CCND1 PROC PROC CAV1 CAV1 ENSNLEP00000032543 ENSNLEP00000032543 BTG1 BTG1 TP63 TP63 ENSNLEP00000033407 ENSNLEP00000033407 ENSNLEP00000033551 ENSNLEP00000033551 STAT1 STAT1 ENSNLEP00000034652 ENSNLEP00000034652 ROCK2 ROCK2 NKX6-3 NKX6-3 KLF7 KLF7 PRLR PRLR FGF2 FGF2 ZBED2 ZBED2 BAD BAD SPRED2 SPRED2 RFX3 RFX3 VCL VCL PLAAT4 PLAAT4 TBX3 TBX3 XDH XDH KIAA1109 KIAA1109 ROCK1 ROCK1 PAX6 PAX6 ETV2 ETV2 IL1B IL1B ENSNLEP00000045603 ENSNLEP00000045603 WNT10B WNT10B LOC100582337 LOC100582337 SGPP1 SGPP1 CDKN2B CDKN2B TNF TNF SFRP4 SFRP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FSTFollistatin. (317 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1558 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
REG3GRegenerating family member 3 gamma. (175 aa)
REG3ARegenerating family member 3 alpha. (175 aa)
FOXJ2Forkhead box J2. (573 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (247 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
FOXN1Forkhead box N1. (648 aa)
LHX1LIM homeobox 1. (352 aa)
NFE2L1Nuclear factor, erythroid 2 like 1. (757 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
ESRP1Epithelial splicing regulatory protein 1. (684 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
APOLD1Uncharacterized protein. (267 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (687 aa)
SULT2B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (358 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
AQP3Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (266 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GDF3Growth differentiation factor 3. (364 aa)
ETV4ETS variant 4. (398 aa)
CTNNB1Catenin beta 1. (781 aa)
FRZBFrizzled related protein. (325 aa)
SRSF6Serine and arginine rich splicing factor 6. (344 aa)
NOTCH4Uncharacterized protein. (1913 aa)
MMP9Matrix metallopeptidase 9. (692 aa)
NCOA3Nuclear receptor coactivator. (1419 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
ABCA12ATP binding cassette subfamily A member 12. (2550 aa)
MAFGMAF bZIP transcription factor G. (162 aa)
G1R9J5_NOMLESAM domain-containing protein. (574 aa)
AJAP1Adherens junctions associated protein 1. (410 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
NOTCH1Notch receptor 1. (2451 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
NKX6-1NK6 homeobox 1. (368 aa)
DSPPUncharacterized protein. (1265 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (155 aa)
NKX2-2NK2 homeobox 2. (273 aa)
KRT36Keratin 36; Belongs to the intermediate filament family. (417 aa)
CEACAM1Uncharacterized protein. (493 aa)
MACROH2A2H2A histone family member Y2. (322 aa)
STAT5BSignal transducer and activator of transcription. (650 aa)
BMP6TGF_BETA_2 domain-containing protein. (125 aa)
MESP1Uncharacterized protein. (170 aa)
GATA3GATA binding protein 3. (444 aa)
MYCLMYCL proto-oncogene, bHLH transcription factor. (364 aa)
KEAP1BTB domain-containing protein. (395 aa)
PAX4Paired box 4. (352 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (683 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
PTCH2Patched 2. (1171 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ZFP36ZFP36 ring finger protein. (322 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1157 aa)
TRIM16Uncharacterized protein. (454 aa)
AHI1Abelson helper integration site 1. (1195 aa)
PAX2Paired domain-containing protein. (385 aa)
MAFFMAF bZIP transcription factor F. (170 aa)
GDF2Growth differentiation factor 2. (429 aa)
NODALNodal growth differentiation factor. (347 aa)
PROM1Prominin 1. (865 aa)
PTCH1Patched 1. (1446 aa)
SIX2SIX homeobox 2. (293 aa)
SPRED3Uncharacterized protein. (438 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
NUMA1Uncharacterized protein. (947 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
KRT84Keratin 84; Belongs to the intermediate filament family. (560 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
VDRVitamin D receptor. (427 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1105 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
ATOH1Atonal bHLH transcription factor 1. (354 aa)
G1SB75_NOMLEUncharacterized protein. (81 aa)
COMMD5COMM domain containing 5. (224 aa)
F11RF11 receptor. (299 aa)
CDKN1BUncharacterized protein. (204 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
SOX9SRY-box transcription factor 9. (510 aa)
ENSNLEP00000027393Uncharacterized protein. (308 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (235 aa)
SPRED1Sprouty related EVH1 domain containing 1. (444 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
ENSNLEP00000028086Fork-head domain-containing protein. (459 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (737 aa)
GDNFTGF_BETA_2 domain-containing protein. (169 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
VEZF1Vascular endothelial zinc finger 1. (521 aa)
ADD1Adducin 1. (753 aa)
MACROH2A1H2A histone family member Y; Belongs to the histone H2A family. (363 aa)
CD109CD109 molecule. (1405 aa)
YAP1Uncharacterized protein. (418 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PROCProtein C, inactivator of coagulation factors Va and VIIIa; Belongs to the peptidase S1 family. (457 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ENSNLEP00000032543Uncharacterized protein. (168 aa)
BTG1BTG anti-proliferation factor 1. (171 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ENSNLEP00000033407Uncharacterized protein. (484 aa)
ENSNLEP00000033551Uncharacterized protein. (169 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
ENSNLEP00000034652Uncharacterized protein. (265 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
NKX6-3Homeobox domain-containing protein. (265 aa)
KLF7Uncharacterized protein. (269 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (622 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
ZBED2Zinc finger BED-type containing 2. (216 aa)
BADUncharacterized protein. (82 aa)
SPRED2Sprouty related EVH1 domain containing 2. (418 aa)
RFX3Regulatory factor X3. (760 aa)
VCLVinculin. (1091 aa)
PLAAT4LRAT domain-containing protein. (163 aa)
TBX3T-box transcription factor 3. (743 aa)
XDHXanthine dehydrogenase. (1271 aa)
KIAA1109KIAA1109. (4964 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
PAX6Uncharacterized protein. (456 aa)
ETV2ETS variant 2. (337 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ENSNLEP00000045603Uncharacterized protein. (252 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
LOC100582337Nucleoside diphosphate kinase. (147 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (381 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SFRP4Secreted frizzled related protein 4. (369 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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