97 items (Nomascus leucogenys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	FYN	Tyrosine-protein kinase. (537 aa)
	SMAD7	Mothers against decapentaplegic homolog. (376 aa)
	RPS3	Ribosomal_S3_C domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (190 aa)
	ENSNLEP00000047524	Ribosomal_L18_c domain-containing protein. (259 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (1024 aa)
	SPOPL	Speckle type BTB/POZ protein like. (392 aa)
	TNFAIP3	TNF alpha induced protein 3. (790 aa)
	PABPN1L	Uncharacterized protein. (186 aa)
	TSPO	Translocator protein. (169 aa)
	BAG5	BCL2 associated athanogene 5. (482 aa)
	RPS15	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. (152 aa)
	LOC100584186	KH type-2 domain-containing protein. (260 aa)
	GNL3L	G protein nucleolar 3 like. (582 aa)
	ENSNLEP00000046123	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (136 aa)
	ENSNLEP00000045640	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (167 aa)
	PINX1	PIN2 (TERF1) interacting telomerase inhibitor 1. (327 aa)
	FBXO5	F-box protein 5. (428 aa)
	PLAA	Phospholipase A2 activating protein. (764 aa)
	PRKCE	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
	ARRB1	Arrestin beta 1. (418 aa)
	MINAR1	UPF0258 domain-containing protein. (916 aa)
	ENSNLEP00000044651	EF-hand domain-containing protein. (184 aa)
	ENSNLEP00000043971	Uncharacterized protein. (108 aa)
	ENSNLEP00000043731	Uncharacterized protein. (166 aa)
	NXN	Thioredoxin domain-containing protein. (324 aa)
	ENSNLEP00000041301	Uncharacterized protein. (97 aa)
	GTPBP4	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa)
	SH3RF2	SH3 domain containing ring finger 2. (726 aa)
	MAD2L2	HORMA domain-containing protein. (124 aa)
	GPS2	G protein pathway suppressor 2. (327 aa)
	PARK7	Parkinsonism associated deglycase. (189 aa)
	ENSNLEP00000042502	Ribosomal_L18_c domain-containing protein. (249 aa)
	PRMT3	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (531 aa)
	TRIM44	Tripartite motif containing 44. (344 aa)
	HDAC8	Histone deacetylase 8. (345 aa)
	G1SBG3_NOMLE	Ribosomal_L18_c domain-containing protein. (289 aa)
	M3ZA82_NOMLE	Uncharacterized protein. (697 aa)
	ENSNLEP00000026646	Ribosomal protein L37; Binds to the 23S rRNA. (97 aa)
	N4BP1	NEDD4 binding protein 1. (893 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (338 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
	ENSNLEP00000028618	WD_REPEATS_REGION domain-containing protein. (470 aa)
	ENSNLEP00000029188	Uncharacterized protein. (60 aa)
	ENSNLEP00000030327	HORMA domain-containing protein. (98 aa)
	OTUB2	OTU deubiquitinase, ubiquitin aldehyde binding 2. (235 aa)
	CAMLG	Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (296 aa)
	MAD2L1	Mitotic arrest deficient 2 like 1. (205 aa)
	SIRT7	Sirtuin 7. (470 aa)
	TTC36	Tetratricopeptide repeat domain 36. (191 aa)
	USP4	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (963 aa)
	CRY1	Cryptochrome circadian regulator 1. (586 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
	USP44	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (686 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
	UBXN1	UBX domain protein 1. (288 aa)
	PPIA	Peptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (165 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	ENSNLEP00000032876	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (133 aa)
	ENSNLEP00000033749	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
	RPS7	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
	ENSNLEP00000034296	DJ-1_PfpI domain-containing protein. (133 aa)
	OTUB1	Ubiquitin thioesterase. (281 aa)
	ENSNLEP00000035481	Uncharacterized protein. (73 aa)
	RPL37	Ribosomal protein L37; Binds to the 23S rRNA. (97 aa)
	LIMK1	Uncharacterized protein. (614 aa)
	IVNS1ABP	Influenza virus NS1A binding protein. (642 aa)
	LOC100601167	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (180 aa)
	ENSNLEP00000036861	Uncharacterized protein. (119 aa)
	ENSNLEP00000036907	Uncharacterized protein. (306 aa)
	DTX3L	Deltex E3 ubiquitin ligase 3L. (740 aa)
	ENSNLEP00000039723	G domain-containing protein. (542 aa)
	ENSNLEP00000040619	Ribosomal_L18_c domain-containing protein. (284 aa)
	UBR5	Ubiquitin protein ligase E3 component n-recognin 5. (2778 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (637 aa)
	CHP1	Calcineurin like EF-hand protein 1. (195 aa)
	BAG2	BCL2 associated athanogene 2. (211 aa)
	BUB1B	BUB1 N-terminal domain-containing protein. (1056 aa)
	PARP10	Poly [ADP-ribose] polymerase. (1036 aa)
	SQSTM1	UBA_5 domain-containing protein. (197 aa)
	SOX4	Transcription factor SOX. (459 aa)
	ADGRB1	Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1489 aa)
	MARCHF7	Membrane associated ring-CH-type finger 7. (703 aa)
	TAF1	TATA-box binding protein associated factor 1. (1767 aa)
	UFL1	UFM1 specific ligase 1. (794 aa)
	ENSNLEP00000041504	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (179 aa)
	GLMN	Glomulin, FKBP associated protein. (550 aa)
	RPL5	Ribosomal protein L5. (297 aa)
	U2AF2	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family. (432 aa)
	VPS28	VPS28 N-terminal domain-containing protein; Belongs to the VPS28 family. (197 aa)
	PER2	Period circadian regulator 2. (1277 aa)
	SVBP	Small vasohibin binding protein. (66 aa)
	ABL1	Tyrosine-protein kinase. (1006 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	CDC20	Cell division cycle 20. (498 aa)
	TRIP12	Thyroid hormone receptor interactor 12. (2069 aa)
	ENSNLEP00000040637	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (166 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	CDK5	ENSNLEP00000015256	ENSNLEP00000005013	Tyrosine-protein kinase.	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	0.731
ABL1	ENSNLEP00000036861	ENSNLEP00000015256	ENSNLEP00000036861	Tyrosine-protein kinase.	Uncharacterized protein.	0.731
AKT1	ARRB1	ENSNLEP00000028045	ENSNLEP00000020570	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Arrestin beta 1.	0.847
AKT1	ATG5	ENSNLEP00000028045	ENSNLEP00000016123	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.551
AKT1	CAV1	ENSNLEP00000028045	ENSNLEP00000032226	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.448
AKT1	FYN	ENSNLEP00000028045	ENSNLEP00000041056	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.706
AKT1	PER2	ENSNLEP00000028045	ENSNLEP00000013720	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Period circadian regulator 2.	0.460
AKT1	PSEN1	ENSNLEP00000028045	ENSNLEP00000031012	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.419
AKT1	SMAD7	ENSNLEP00000028045	ENSNLEP00000048725	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.619
AKT1	SQSTM1	ENSNLEP00000028045	ENSNLEP00000002152	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	UBA_5 domain-containing protein.	0.555
ARRB1	AKT1	ENSNLEP00000020570	ENSNLEP00000028045	Arrestin beta 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.847
ATG5	AKT1	ENSNLEP00000016123	ENSNLEP00000028045	Autophagy protein 5; Involved in autophagic vesicle formation.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.551
ATG5	ENSNLEP00000035481	ENSNLEP00000016123	ENSNLEP00000035481	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.723
ATG5	SQSTM1	ENSNLEP00000016123	ENSNLEP00000002152	Autophagy protein 5; Involved in autophagic vesicle formation.	UBA_5 domain-containing protein.	0.909
BAG2	BAG5	ENSNLEP00000003393	ENSNLEP00000019643	BCL2 associated athanogene 2.	BCL2 associated athanogene 5.	0.808
BAG5	BAG2	ENSNLEP00000019643	ENSNLEP00000003393	BCL2 associated athanogene 5.	BCL2 associated athanogene 2.	0.808
BUB1B	CDC20	ENSNLEP00000003290	ENSNLEP00000016408	BUB1 N-terminal domain-containing protein.	Cell division cycle 20.	0.998
BUB1B	ENSNLEP00000028618	ENSNLEP00000003290	ENSNLEP00000028618	BUB1 N-terminal domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.995
BUB1B	ENSNLEP00000030327	ENSNLEP00000003290	ENSNLEP00000030327	BUB1 N-terminal domain-containing protein.	HORMA domain-containing protein.	0.993
BUB1B	FBXO5	ENSNLEP00000003290	ENSNLEP00000045591	BUB1 N-terminal domain-containing protein.	F-box protein 5.	0.605

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