STRINGSTRING
ENSNLEP00000049177 ENSNLEP00000049177 RAB15 RAB15 SRC SRC ANKRD26 ANKRD26 HMGCS2 HMGCS2 MYO5A MYO5A GHR GHR IRS2 IRS2 ENSNLEP00000045877 ENSNLEP00000045877 PIK3R3 PIK3R3 GPLD1 GPLD1 RAB8A RAB8A PTPN2 PTPN2 IGF1R IGF1R SLC25A33 SLC25A33 LOC100604571 LOC100604571 SELENOS SELENOS XBP1 XBP1 ENSNLEP00000042424 ENSNLEP00000042424 ENSNLEP00000042160 ENSNLEP00000042160 AKT2 AKT2 BCAR3 BCAR3 IDE IDE BCAR1 BCAR1 DENND4C DENND4C GRB2 GRB2 LOC100593010 LOC100593010 CAPN10 CAPN10 NCOA5 NCOA5 GRB10 GRB10 FOXO4 FOXO4 EEF2K EEF2K ENSNLEP00000037007 ENSNLEP00000037007 PPARG PPARG ENSNLEP00000036739 ENSNLEP00000036739 CPEB1 CPEB1 AP3S1 AP3S1 SLC39A14 SLC39A14 ENSNLEP00000035372 ENSNLEP00000035372 IRS1 IRS1 ENSNLEP00000035134 ENSNLEP00000035134 SORBS1 SORBS1 STAT1 STAT1 BAIAP2 BAIAP2 ENSNLEP00000032399 ENSNLEP00000032399 ENSNLEP00000032035 ENSNLEP00000032035 PIK3R1 PIK3R1 SREBF1 SREBF1 IGF2 IGF2 CYFIP1 CYFIP1 LPIN1 LPIN1 SLC27A1 SLC27A1 CPEB2 CPEB2 RAB13 RAB13 RAB31 RAB31 AKT1 AKT1 SLC22A12 SLC22A12 GCK GCK EPRS1 EPRS1 C2CD5 C2CD5 GSK3B GSK3B ENSNLEP00000026090 ENSNLEP00000026090 KAT2B KAT2B ENSNLEP00000025390 ENSNLEP00000025390 LPIN3 LPIN3 RHOQ RHOQ M3Z9R7_NOMLE M3Z9R7_NOMLE PRKCI PRKCI USF1 USF1 IRS4 IRS4 CSRP3 CSRP3 PDE3B PDE3B SP1 SP1 SLC2A8 SLC2A8 CDK4 CDK4 FBP1 FBP1 HDAC9 HDAC9 OTOP1 OTOP1 TBC1D4 TBC1D4 EIF4EBP2 EIF4EBP2 PDK4 PDK4 PNPLA3 PNPLA3 PLA2G1B PLA2G1B APRT APRT GHRHR GHRHR PCK2 PCK2 CCDC144A CCDC144A PCSK9 PCSK9 GOT1 GOT1 ENPP1 ENPP1 PARP1 PARP1 PRKDC PRKDC INSRR INSRR PHIP PHIP LEP LEP APC APC CAV2 CAV2 SRD5A1 SRD5A1 ZDHHC7 ZDHHC7 FER FER GPT GPT CEACAM1 CEACAM1 INSIG1 INSIG1 GSK3A GSK3A SYAP1 SYAP1 TRIB3 TRIB3 WDTC1 WDTC1 SLC9A1 SLC9A1 LOC100592336 LOC100592336 RPE65 RPE65 PDK2 PDK2 ERRFI1 ERRFI1 SH2B2 SH2B2 SLC2A4 SLC2A4 STXBP4 STXBP4 PTPRA PTPRA APPL1 APPL1 PCK1 PCK1 RAB12 RAB12 LPIN2 LPIN2 ADIPOQ ADIPOQ SMARCC1 SMARCC1 SOGA1 SOGA1 SLC29A2 SLC29A2 PIK3R2 PIK3R2 PIK3CA PIK3CA POU4F2 POU4F2 GHSR GHSR GAB1 GAB1 DNAI1 DNAI1 ZNF106 ZNF106 IGFBP1 IGFBP1 GCLC GCLC RB1 RB1 GRB14 GRB14 SRSF5 SRSF5 RAB10 RAB10 LOC100598080 LOC100598080 FOXO1 FOXO1 KL KL ZFP36L1 ZFP36L1 INPP5K INPP5K RPS6KB1 RPS6KB1 TRARG1 TRARG1 INSR INSR PRKCZ PRKCZ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSNLEP00000049177Uncharacterized protein. (137 aa)
RAB15Uncharacterized protein. (244 aa)
SRCTyrosine-protein kinase. (537 aa)
ANKRD26Ankyrin repeat domain 26. (1708 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
MYO5AMyosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1867 aa)
GHRGrowth hormone receptor. (645 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
ENSNLEP00000045877Uncharacterized protein. (116 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (840 aa)
RAB8ARAB8A, member RAS oncogene family. (197 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
IGF1RTyrosine-protein kinase receptor. (1199 aa)
SLC25A33Solute carrier family 25 member 33; Belongs to the mitochondrial carrier (TC 2.A.29) family. (324 aa)
LOC100604571ANK_REP_REGION domain-containing protein. (213 aa)
SELENOSUncharacterized protein. (218 aa)
XBP1BZIP domain-containing protein. (376 aa)
ENSNLEP00000042424Tyrosine-protein phosphatase non-receptor type. (405 aa)
ENSNLEP00000042160Tyrosine-protein phosphatase non-receptor type. (386 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (398 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (825 aa)
IDEInsulin degrading enzyme. (976 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (827 aa)
DENND4CDENN domain containing 4C. (1958 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (672 aa)
NCOA5Nuclear receptor coactivator 5. (579 aa)
GRB10Growth factor receptor bound protein 10. (612 aa)
FOXO4Forkhead box O4. (505 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
ENSNLEP00000037007Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (786 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
ENSNLEP00000036739Uncharacterized protein. (120 aa)
CPEB1Cytoplasmic polyadenylation element binding protein 1. (615 aa)
AP3S1Adaptor related protein complex 3 subunit sigma 1. (193 aa)
SLC39A14Solute carrier family 39 member 14. (490 aa)
ENSNLEP00000035372TGF_BETA_2 domain-containing protein. (392 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
ENSNLEP00000035134Uncharacterized protein. (101 aa)
SORBS1Uncharacterized protein. (1293 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
BAIAP2BAI1 associated protein 2. (561 aa)
ENSNLEP00000032399Uncharacterized protein. (628 aa)
ENSNLEP00000032035Uncharacterized protein. (107 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
IGF2IlGF domain-containing protein. (180 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1228 aa)
LPIN1Lipin 1. (975 aa)
SLC27A1Solute carrier family 27 member 1. (571 aa)
CPEB2Uncharacterized protein. (500 aa)
RAB13Uncharacterized protein. (203 aa)
RAB31RAB31, member RAS oncogene family. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
SLC22A12Solute carrier family 22 member 12. (553 aa)
GCKPhosphotransferase. (427 aa)
EPRS1Glutamyl-prolyl-tRNA synthetase. (1512 aa)
C2CD5C2 calcium dependent domain containing 5. (1042 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
ENSNLEP000000260903-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (258 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (799 aa)
ENSNLEP00000025390Tyrosine-protein phosphatase non-receptor type. (391 aa)
LPIN3Lipin 3. (859 aa)
RHOQUncharacterized protein. (190 aa)
M3Z9R7_NOMLECCDC144C domain-containing protein. (979 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
USF1Upstream transcription factor 1. (310 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
PDE3BPhosphodiesterase. (791 aa)
SP1Sp1 transcription factor. (786 aa)
SLC2A8Solute carrier family 2 member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
FBP1Fructose-bisphosphatase 1. (281 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
OTOP1Otopetrin 1. (612 aa)
TBC1D4TBC1 domain family member 4. (1298 aa)
EIF4EBP2Uncharacterized protein. (120 aa)
PDK4Protein-serine/threonine kinase. (411 aa)
PNPLA3Patatin like phospholipase domain containing 3. (463 aa)
PLA2G1BPhospholipase A(2). (148 aa)
APRTAdenine phosphoribosyltransferase. (180 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (424 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (575 aa)
CCDC144AUncharacterized protein. (1340 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (693 aa)
GOT1Aspartate aminotransferase. (413 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (827 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (948 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit. (3853 aa)
INSRRTyrosine-protein kinase receptor. (1287 aa)
PHIPPleckstrin homology domain interacting protein. (1953 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (86 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (345 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
GPTGlutamic--pyruvic transaminase. (509 aa)
CEACAM1Uncharacterized protein. (493 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (274 aa)
GSK3AGlycogen synthase kinase 3 alpha. (439 aa)
SYAP1Synapse associated protein 1. (293 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
WDTC1WD and tetratricopeptide repeats 1. (677 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (809 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
RPE65Retinoid isomerohydrolase RPE65. (533 aa)
PDK2Protein-serine/threonine kinase. (415 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
SH2B2Uncharacterized protein. (579 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (481 aa)
STXBP4Syntaxin binding protein 4. (539 aa)
PTPRAReceptor-type tyrosine-protein phosphatase alpha. (802 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (674 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (608 aa)
RAB12RAB12, member RAS oncogene family. (244 aa)
LPIN2Lipin 2. (896 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1009 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1643 aa)
SLC29A2Solute carrier family 29 member 2. (371 aa)
PIK3R2Uncharacterized protein. (727 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
POU4F2POU domain protein. (408 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
DNAI1Dynein axonemal intermediate chain 1. (700 aa)
ZNF106Zinc finger protein 106. (1863 aa)
IGFBP1Insulin like growth factor binding protein 1. (281 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
RB1RB transcriptional corepressor 1. (919 aa)
GRB14Growth factor receptor bound protein 14. (540 aa)
SRSF5Serine and arginine rich splicing factor 5. (272 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
LOC100598080ANK_REP_REGION domain-containing protein. (513 aa)
FOXO1Forkhead box O1. (652 aa)
KLKlotho. (855 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (372 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
TRARG1Trafficking regulator of GLUT4 (SLC2A4) 1. (177 aa)
INSRInsulin receptor. (1232 aa)
PRKCZProtein kinase C zeta. (507 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.