STRINGSTRING
LOC100607679 LOC100607679 MMP8 MMP8 MAP2K4 MAP2K4 STK3 STK3 APP APP MAPK1 MAPK1 LTBR LTBR LOC100584404 LOC100584404 DLG1 DLG1 DUSP19 DUSP19 ZMYND11 ZMYND11 MAGI3 MAGI3 LOC100583914 LOC100583914 FZD7 FZD7 ENSNLEP00000031088 ENSNLEP00000031088 EDA2R EDA2R ARL6IP5 ARL6IP5 SCIMP SCIMP ENSNLEP00000032876 ENSNLEP00000032876 DUSP1 DUSP1 EDAR EDAR ENSNLEP00000033428 ENSNLEP00000033428 CYLD CYLD MAPK8IP2 MAPK8IP2 SEMA4C SEMA4C SLAMF1 SLAMF1 SDCBP SDCBP EGFR EGFR ENSNLEP00000036907 ENSNLEP00000036907 MBIP MBIP MECOM MECOM ENSNLEP00000038124 ENSNLEP00000038124 ENSNLEP00000038644 ENSNLEP00000038644 ENSNLEP00000038691 ENSNLEP00000038691 MAP4K4 MAP4K4 HIPK2 HIPK2 FCGR2B FCGR2B NOX1 NOX1 ENSNLEP00000040637 ENSNLEP00000040637 MDFIC MDFIC ENSNLEP00000041902 ENSNLEP00000041902 LOC100586364 LOC100586364 ANKRD6 ANKRD6 ENSNLEP00000042367 ENSNLEP00000042367 TPD52L1 TPD52L1 TAOK2 TAOK2 DIXDC1 DIXDC1 XDH XDH EIF2AK2 EIF2AK2 TRAF4 TRAF4 MAPKBP1 MAPKBP1 ENSNLEP00000042936 ENSNLEP00000042936 TIRAP TIRAP IGF1R IGF1R CCR7 CCR7 DAB2IP DAB2IP ITCH ITCH IL1B IL1B ENSNLEP00000045248 ENSNLEP00000045248 EZR EZR DUSP22 DUSP22 TAOK1 TAOK1 ENSNLEP00000046123 ENSNLEP00000046123 TNFRSF19 TNFRSF19 PRDX1 PRDX1 DUSP10 DUSP10 TNF TNF MAP3K5 MAP3K5 RELL1 RELL1 AXIN1 AXIN1 TAOK3 TAOK3 GADD45G GADD45G CRK CRK RB1CC1 RB1CC1 NOD2 NOD2 FOXO1 FOXO1 MAP2K7 MAP2K7 IL1A IL1A MAPK3 MAPK3 RIPK2 RIPK2 TRPV4 TRPV4 SPHK1 SPHK1 FLT4 FLT4 TRAF5 TRAF5 G1QRG0_NOMLE G1QRG0_NOMLE CRACR2A CRACR2A MAP2K2 MAP2K2 KLHL31 KLHL31 IL26 IL26 GDF6 GDF6 STK39 STK39 DUSP16 DUSP16 CD27 CD27 CAV3 CAV3 EPHB1 EPHB1 PPIA PPIA MAP3K3 MAP3K3 NAIP NAIP PTPN22 PTPN22 CCL21 CCL21 PDCD10 PDCD10 G1QYG1_NOMLE G1QYG1_NOMLE TREM2 TREM2 UNC5CL UNC5CL DNAJA1 DNAJA1 PRMT1 PRMT1 MAP4K2 MAP4K2 MYD88 MYD88 MEN1 MEN1 TNIK TNIK MYC MYC EMC10 EMC10 MAP3K11 MAP3K11 ULK4 ULK4 SFRP2 SFRP2 LOC100580544 LOC100580544 SH3RF1 SH3RF1 AGER AGER HAND2 HAND2 QARS QARS WNT5A WNT5A SH3RF3 SH3RF3 RAP2A RAP2A PAGE1 PAGE1 CARD9 CARD9 HRAS HRAS TRAF2 TRAF2 PHLPP1 PHLPP1 MID1 MID1 GADD45A GADD45A SIRPA SIRPA GPS2 GPS2 HDAC3 HDAC3 RELL2 RELL2 SH3RF2 SH3RF2 PER1 PER1 BIRC7 BIRC7 FGF19 FGF19 COPS5 COPS5 RIPK1 RIPK1 TLR3 TLR3 MAP3K4 MAP3K4 PRKN PRKN RASGRP1 RASGRP1 ZC3H12A ZC3H12A ZNF622 ZNF622 WNT16 WNT16 FAS FAS LEP LEP SFRP1 SFRP1 BMP4 BMP4 KLHDC10 KLHDC10 DACT1 DACT1 AIDA AIDA WNT7B WNT7B STK25 STK25 BMP2 BMP2 MAP3K10 MAP3K10 TGFB2 TGFB2 PLCB1 PLCB1 CCN2 CCN2 SPI1 SPI1 NCOR1 NCOR1 SEMA3A SEMA3A MFHAS1 MFHAS1 NOD1 NOD1 SASH1 SASH1 TRAF3 TRAF3 PYCARD PYCARD PTK2B PTK2B PBK PBK AMBP AMBP TRAF1 TRAF1 SERPINF2 SERPINF2 FKTN FKTN MINK1 MINK1 IGFBP6 IGFBP6 HIPK3 HIPK3 TRAF6 TRAF6 MAPK8IP1 MAPK8IP1 INAVA INAVA MAPK8IP3 MAPK8IP3 PJA2 PJA2 HGF HGF PINK1 PINK1 F2RL1 F2RL1 ENSNLEP00000024692 ENSNLEP00000024692 RASSF2 RASSF2 TNFSF11 TNFSF11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100607679SCY domain-containing protein. (98 aa)
MMP8ZnMc domain-containing protein. (387 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
STK3Serine/threonine kinase 3. (519 aa)
APPAmyloid beta precursor protein. (757 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
LTBRUncharacterized protein. (359 aa)
LOC100584404Uncharacterized protein. (253 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (916 aa)
DUSP19Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (218 aa)
ZMYND11Zinc finger MYND-type containing 11. (617 aa)
MAGI3Membrane associated guanylate kinase, WW and PDZ domain containing 3. (1481 aa)
LOC100583914Uncharacterized protein. (322 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
ENSNLEP00000031088Protein kinase domain-containing protein. (557 aa)
EDA2REctodysplasin A2 receptor. (318 aa)
ARL6IP5PRA1 family protein. (188 aa)
SCIMPSLP adaptor and CSK interacting membrane protein. (143 aa)
ENSNLEP00000032876Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (133 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (326 aa)
EDAREctodysplasin A receptor. (478 aa)
ENSNLEP00000033428Protein kinase domain-containing protein. (369 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
MAPK8IP2PID domain-containing protein. (178 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (331 aa)
SDCBPSyndecan binding protein. (318 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
ENSNLEP00000036907Uncharacterized protein. (306 aa)
MBIPMAP3K12 binding inhibitory protein 1. (345 aa)
MECOMMDS1 and EVI1 complex locus. (1230 aa)
ENSNLEP00000038124JAB_MPN domain-containing protein. (336 aa)
ENSNLEP00000038644SH3 domain-containing protein. (713 aa)
ENSNLEP000000386911-cysPrx_C domain-containing protein. (97 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4. (1346 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
FCGR2BUncharacterized protein. (310 aa)
NOX1NADPH oxidase 1. (564 aa)
ENSNLEP00000040637Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (166 aa)
MDFICMyoD family inhibitor domain containing. (355 aa)
ENSNLEP00000041902Uncharacterized protein. (337 aa)
LOC100586364Uncharacterized protein. (568 aa)
ANKRD6Ankyrin repeat domain 6. (727 aa)
ENSNLEP00000042367PDZ_6 domain-containing protein. (254 aa)
TPD52L1TPD52 like 1. (221 aa)
TAOK2TAO kinase 2. (1246 aa)
DIXDC1DIX domain containing 1. (684 aa)
XDHXanthine dehydrogenase. (1271 aa)
EIF2AK2Uncharacterized protein. (543 aa)
TRAF4TNF receptor-associated factor. (471 aa)
MAPKBP1Mitogen-activated protein kinase binding protein 1. (1514 aa)
ENSNLEP00000042936Protein kinase domain-containing protein. (201 aa)
TIRAPTIR domain containing adaptor protein. (221 aa)
IGF1RTyrosine-protein kinase receptor. (1199 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
DAB2IPDAB2 interacting protein. (1159 aa)
ITCHE3 ubiquitin-protein ligase. (905 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ENSNLEP00000045248GAGE domain-containing protein. (134 aa)
EZREzrin. (586 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (205 aa)
TAOK1TAO kinase 1. (1002 aa)
ENSNLEP00000046123Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (136 aa)
TNFRSF19TNF receptor superfamily member 19. (417 aa)
PRDX1Peroxiredoxin 1. (199 aa)
DUSP10Dual specificity phosphatase 10. (482 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1347 aa)
RELL1RELT like 1. (271 aa)
AXIN1Axin 1. (837 aa)
TAOK3TAO kinase 3. (898 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
CRKUncharacterized protein. (252 aa)
RB1CC1RB1 inducible coiled-coil 1. (1594 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
FOXO1Forkhead box O1. (652 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (391 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (247 aa)
MAPK3Mitogen-activated protein kinase. (278 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (846 aa)
SPHK1DAGKc domain-containing protein. (398 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
G1QRG0_NOMLEFork-head domain-containing protein. (623 aa)
CRACR2ACalcium release activated channel regulator 2A. (721 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (383 aa)
KLHL31Kelch like family member 31. (634 aa)
IL26Interleukin 26. (171 aa)
GDF6Growth differentiation factor 6. (455 aa)
STK39Serine/threonine kinase 39. (507 aa)
DUSP16Dual specificity phosphatase 16. (662 aa)
CD27CD27 molecule. (259 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
EPHB1EPH receptor B1. (984 aa)
PPIAPeptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (165 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (628 aa)
NAIPNLR family apoptosis inhibitory protein. (1257 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (807 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
PDCD10Programmed cell death 10. (212 aa)
G1QYG1_NOMLEProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (323 aa)
TREM2Ig-like domain-containing protein. (222 aa)
UNC5CLUnc-5 family C-terminal like. (518 aa)
DNAJA1Uncharacterized protein. (397 aa)
PRMT1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (323 aa)
MAP4K2Uncharacterized protein. (658 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
MEN1Menin 1. (614 aa)
TNIKTRAF2 and NCK interacting kinase. (1360 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
EMC10Uncharacterized protein. (347 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (847 aa)
ULK4Unc-51 like kinase 4. (1233 aa)
SFRP2Secreted frizzled related protein 2. (280 aa)
LOC100580544Uncharacterized protein; Belongs to the GST superfamily. (206 aa)
SH3RF1SH3 domain containing ring finger 1. (887 aa)
AGERAdvanced glycosylation end-product specific receptor. (404 aa)
HAND2Heart and neural crest derivatives expressed 2. (198 aa)
QARSUncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (626 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SH3RF3SH3 domain containing ring finger 3. (823 aa)
RAP2ARAP2A, member of RAS oncogene family. (183 aa)
PAGE1PAGE family member 1. (147 aa)
CARD9Caspase recruitment domain family member 9. (536 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
PHLPP1Uncharacterized protein. (1264 aa)
MID1Midline 1. (667 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
SIRPAUncharacterized protein. (486 aa)
GPS2G protein pathway suppressor 2. (327 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
RELL2RELT like 2. (302 aa)
SH3RF2SH3 domain containing ring finger 2. (726 aa)
PER1Period circadian regulator 1. (1268 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
COPS5COP9 signalosome subunit 5. (334 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1592 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (437 aa)
RASGRP1RAS guanyl releasing protein 1. (785 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (560 aa)
ZNF622Zinc finger protein 622. (477 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
FASFas cell surface death receptor. (335 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
KLHDC10Kelch domain containing 10. (442 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (837 aa)
AIDAAxin interactor, dorsalization associated. (306 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
STK25Serine/threonine kinase 25. (416 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
MAP3K10Protein kinase domain-containing protein. (689 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CCN2Cellular communication network factor 2. (349 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
NCOR1Nuclear receptor corepressor 1. (2442 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (771 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1037 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
SASH1SAM and SH3 domain containing 1. (1247 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
PYCARDPYD and CARD domain containing. (195 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
PBKPDZ binding kinase. (333 aa)
AMBPAlpha-1-microglobulin/bikunin precursor. (312 aa)
TRAF1TNF receptor-associated factor. (416 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (468 aa)
FKTNFukutin. (456 aa)
MINK1Misshapen like kinase 1. (1259 aa)
IGFBP6Insulin like growth factor binding protein 6. (240 aa)
HIPK3Homeodomain interacting protein kinase 3. (1215 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (665 aa)
INAVAInnate immunity activator. (596 aa)
MAPK8IP3Mitogen-activated protein kinase 8 interacting protein 3. (1316 aa)
PJA2Praja ring finger ubiquitin ligase 2. (708 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
PINK1Protein kinase domain-containing protein. (563 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
ENSNLEP00000024692Uncharacterized protein. (267 aa)
RASSF2Ras-associating domain-containing protein. (451 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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