STRINGSTRING
ECT2 ECT2 NFE2L2 NFE2L2 CAMKK2 CAMKK2 KLF2 KLF2 SMPD3 SMPD3 FOS FOS AKR1C3 AKR1C3 MAP3K5 MAP3K5 RPS3 RPS3 PARK7 PARK7 STAT6 STAT6 CAT CAT HDAC6 HDAC6 CHUK CHUK MAPK10 MAPK10 MAPK1 MAPK1 MPV17 MPV17 AKT1 AKT1 PPIF PPIF EZH2 EZH2 FER FER RIPK1 RIPK1 SOD2 SOD2 ROMO1 ROMO1 PPARGC1B PPARGC1B PKD2 PKD2 SIRPA SIRPA ANKZF1 ANKZF1 FXN FXN MAPK13 MAPK13 MAPK9 MAPK9 LOC100593245 LOC100593245 ENSNLEP00000029188 ENSNLEP00000029188 SLC8A1 SLC8A1 ENSNLEP00000037793 ENSNLEP00000037793 RELA RELA SOD3 SOD3 EGFR EGFR CCS CCS MAP1LC3A MAP1LC3A UCP1 UCP1 PRDX5 PRDX5 PDCD10 PDCD10 SIGMAR1 SIGMAR1 AGAP3 AGAP3 NOS3 NOS3 SOD1 SOD1 FABP1 FABP1 NME8 NME8 SPHK1 SPHK1 MAPK3 MAPK3 ATP7A ATP7A MMP2 MMP2 EDN1 EDN1 PCGF2 PCGF2 HSF1 HSF1 SETX SETX STK25 STK25 ARG1 ARG1 NET1 NET1 NQO1 NQO1 PRDX2 PRDX2 TRPA1 TRPA1 TNFAIP3 TNFAIP3 SIRT1 SIRT1 ABL1 ABL1 PDK2 PDK2 ERN1 ERN1 AIFM1 AIFM1 RNF112 RNF112 MAPK7 MAPK7 MPO MPO JUN JUN PAX2 PAX2 RIPK3 RIPK3 FYN FYN RHOB RHOB AQP1 AQP1 CYP1B1 CYP1B1 FANCC FANCC AMBP AMBP PCNA PCNA BTK BTK ERCC6L2 ERCC6L2 PXN PXN ENSNLEP00000048874 ENSNLEP00000048874 PLEKHA1 PLEKHA1 IL18BP IL18BP PTPRK PTPRK ENSNLEP00000045860 ENSNLEP00000045860 MAPK8 MAPK8 LOC100584186 LOC100584186 ZNF277 ZNF277 PRDX1 PRDX1 BNIP3 BNIP3 ENSNLEP00000032236 ENSNLEP00000032236 TPM1 TPM1 ENSNLEP00000034296 ENSNLEP00000034296 IL6 IL6 ADPRHL2 ADPRHL2 ENSNLEP00000038691 ENSNLEP00000038691 HDAC2 HDAC2 TRPM2 TRPM2 CRYGD CRYGD SRC SRC AXL AXL APOA4 APOA4 PRKCD PRKCD MMP9 MMP9 OSER1 OSER1 IMPACT IMPACT PJVK PJVK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ECT2Epithelial cell transforming 2. (914 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (607 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (591 aa)
KLF2Kruppel like factor 2. (355 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
AKR1C3Aldo-keto reductase family 1 member C3. (323 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1347 aa)
RPS3Ribosomal_S3_C domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (190 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
STAT6Signal transducer and activator of transcription. (842 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
HDAC6Uncharacterized protein. (146 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
MPV17Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (191 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (205 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
PPARGC1BPPARG coactivator 1 beta. (1013 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (921 aa)
SIRPAUncharacterized protein. (486 aa)
ANKZF1Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (727 aa)
FXNUncharacterized protein. (196 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
LOC100593245Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (176 aa)
ENSNLEP00000029188Uncharacterized protein. (60 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (972 aa)
ENSNLEP00000037793Uncharacterized protein. (122 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (240 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
CCSCopper chaperone for superoxide dismutase. (274 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (124 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (158 aa)
PDCD10Programmed cell death 10. (212 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (223 aa)
AGAP3ArfGAP with GTPase domain, ankyrin repeat and PH domain 3. (742 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
FABP1Fatty acid binding protein 1. (127 aa)
NME8NME/NM23 family member 8. (588 aa)
SPHK1DAGKc domain-containing protein. (398 aa)
MAPK3Mitogen-activated protein kinase. (278 aa)
ATP7AATPase copper transporting alpha. (1460 aa)
MMP2Matrix metallopeptidase 2. (647 aa)
EDN1Endothelin 1. (211 aa)
PCGF2RING-type domain-containing protein. (274 aa)
HSF1HSF_DOMAIN domain-containing protein. (272 aa)
SETXSenataxin. (2576 aa)
STK25Serine/threonine kinase 25. (416 aa)
ARG1Arginase. (322 aa)
NET1Neuroepithelial cell transforming 1. (596 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (261 aa)
PRDX2Peroxiredoxin 2. (163 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1094 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
SIRT1Sirtuin 1. (734 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
PDK2Protein-serine/threonine kinase. (415 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
RNF112Ring finger protein 112. (643 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
MPOMyeloperoxidase. (745 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (305 aa)
PAX2Paired domain-containing protein. (385 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (506 aa)
FYNTyrosine-protein kinase. (537 aa)
RHOBRas homolog family member B. (196 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (526 aa)
AMBPAlpha-1-microglobulin/bikunin precursor. (312 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
BTKTyrosine-protein kinase. (659 aa)
ERCC6L2ERCC excision repair 6 like 2. (712 aa)
PXNUncharacterized protein. (1078 aa)
ENSNLEP00000048874Uncharacterized protein. (178 aa)
PLEKHA1Pleckstrin homology domain containing A1. (404 aa)
IL18BPInterleukin 18 binding protein. (194 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1416 aa)
ENSNLEP00000045860Uncharacterized protein. (64 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
LOC100584186KH type-2 domain-containing protein. (260 aa)
ZNF277Zinc finger protein 277. (442 aa)
PRDX1Peroxiredoxin 1. (199 aa)
BNIP3Uncharacterized protein. (231 aa)
ENSNLEP00000032236Uncharacterized protein. (109 aa)
TPM1Uncharacterized protein; Belongs to the tropomyosin family. (326 aa)
ENSNLEP00000034296DJ-1_PfpI domain-containing protein. (133 aa)
IL6Uncharacterized protein. (258 aa)
ADPRHL2ADP-ribosylhydrolase like 2. (364 aa)
ENSNLEP000000386911-cysPrx_C domain-containing protein. (97 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (533 aa)
TRPM2LSDAT_euk domain-containing protein. (1224 aa)
CRYGDUncharacterized protein; Belongs to the beta/gamma-crystallin family. (174 aa)
SRCTyrosine-protein kinase. (537 aa)
AXLReceptor protein-tyrosine kinase. (860 aa)
APOA4Apolipoprotein A4. (392 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
MMP9Matrix metallopeptidase 9. (692 aa)
OSER1Oxidative stress responsive serine rich 1. (292 aa)
IMPACTImpact RWD domain protein. (320 aa)
PJVKPejvakin. (352 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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