STRINGSTRING
IFT122 IFT122 PIFO PIFO SETDB2 SETDB2 HIF1A HIF1A PITX2 PITX2 CLUAP1 CLUAP1 SUFU SUFU ENSNLEP00000045603 ENSNLEP00000045603 TBX2 TBX2 NKX2-5 NKX2-5 EDN1 EDN1 MED1 MED1 ACVR1 ACVR1 SOX17 SOX17 FOXN4 FOXN4 TBX20 TBX20 TMED2 TMED2 ARL13B ARL13B TBX6 TBX6 ZIC3 ZIC3 NDRG4 NDRG4 IFT172 IFT172 TGFBR2 TGFBR2 SRF SRF BBS5 BBS5 CCDC103 CCDC103 NOTCH2 NOTCH2 EDNRA EDNRA CTNNB1 CTNNB1 CCDC39 CCDC39 IFT52 IFT52 HAND2 HAND2 NOTO NOTO SOX18 SOX18 PKD2 PKD2 TBX3 TBX3 BBS7 BBS7 IHH IHH NOTCH1 NOTCH1 WNT5A WNT5A MIB1 MIB1 SMAD3 SMAD3 CDC42 CDC42 ENSNLEP00000039759 ENSNLEP00000039759 LOC100593615 LOC100593615 MEF2C MEF2C ENSNLEP00000032543 ENSNLEP00000032543 YAP1 YAP1 FOLR1 FOLR1 PSEN1 PSEN1 DLL1 DLL1 ENSNLEP00000028086 ENSNLEP00000028086 IFT57 IFT57 WNT3A WNT3A ENG ENG MEGF8 MEGF8 MICALCL MICALCL MICAL2 MICAL2 ASB2 ASB2 RYR2 RYR2 C2CD3 C2CD3 HAND1 HAND1 STIL STIL NODAL NODAL NKX2-6 NKX2-6 CCDC40 CCDC40 GATA4 GATA4 CITED2 CITED2 FGF8 FGF8 LBX1 LBX1 AHI1 AHI1 BBS4 BBS4 VANGL2 VANGL2 PLXNA4 PLXNA4 SMO SMO APLNR APLNR MESP1 MESP1 G1RJG4_NOMLE G1RJG4_NOMLE FOXH1 FOXH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFT122Intraflagellar transport 122. (1266 aa)
PIFOPrimary cilia formation. (191 aa)
SETDB2SET domain bifurcated histone lysine methyltransferase 2. (718 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
PITX2Homeobox protein. (420 aa)
CLUAP1Clusterin associated protein 1. (431 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (526 aa)
ENSNLEP00000045603Uncharacterized protein. (252 aa)
TBX2T-box transcription factor 2. (647 aa)
NKX2-5NK2 homeobox 5. (317 aa)
EDN1Endothelin 1. (211 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1558 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SOX17SRY-box transcription factor 17. (410 aa)
FOXN4Forkhead box N4. (517 aa)
TBX20T-box transcription factor 20. (447 aa)
TMED2Transmembrane p24 trafficking protein 2. (199 aa)
ARL13BADP ribosylation factor like GTPase 13B. (428 aa)
TBX6T-box transcription factor 6. (364 aa)
ZIC3Uncharacterized protein. (360 aa)
NDRG4NDRG family member 4. (391 aa)
IFT172Intraflagellar transport 172. (1703 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SRFSerum response factor. (508 aa)
BBS5Bardet-Biedl syndrome 5 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the gua [...] (341 aa)
CCDC103Coiled-coil domain containing 103. (242 aa)
NOTCH2Notch receptor 2. (2444 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CTNNB1Catenin beta 1. (781 aa)
CCDC39Coiled-coil domain containing 39. (942 aa)
IFT52Intraflagellar transport 52. (396 aa)
HAND2Heart and neural crest derivatives expressed 2. (198 aa)
NOTONotochord homeobox. (251 aa)
SOX18SRY-box transcription factor 18. (362 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (921 aa)
TBX3T-box transcription factor 3. (743 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
IHHIndian hedgehog signaling molecule. (389 aa)
NOTCH1Notch receptor 1. (2451 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (985 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CDC42Cell division cycle 42. (191 aa)
ENSNLEP00000039759GOLD domain-containing protein. (183 aa)
LOC100593615TPR_REGION domain-containing protein. (160 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ENSNLEP00000032543Uncharacterized protein. (168 aa)
YAP1Uncharacterized protein. (418 aa)
FOLR1Folate receptor alpha. (228 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (737 aa)
ENSNLEP00000028086Fork-head domain-containing protein. (459 aa)
IFT57Intraflagellar transport 57. (429 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ENGEndoglin. (658 aa)
MEGF8Multiple EGF like domains 8. (2574 aa)
MICALCLBMERB domain-containing protein. (420 aa)
MICAL2Microtubule associated monooxygenase, calponin and LIM domain containing 2. (1124 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (635 aa)
RYR2Ryanodine receptor 2. (4825 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2317 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
STILSTIL centriolar assembly protein. (1279 aa)
NODALNodal growth differentiation factor. (347 aa)
NKX2-6NK2 homeobox 6. (301 aa)
CCDC40Coiled-coil domain containing 40. (1137 aa)
GATA4GATA binding protein 4. (443 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
LBX1Ladybird homeobox 1. (281 aa)
AHI1Abelson helper integration site 1. (1195 aa)
BBS4Bardet-Biedl syndrome 4. (518 aa)
VANGL2Uncharacterized protein. (435 aa)
PLXNA4Plexin A4. (1864 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (683 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
MESP1Uncharacterized protein. (170 aa)
G1RJG4_NOMLEDynein assembly factor 1, axonemal. (655 aa)
FOXH1Forkhead box H1. (366 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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